Institute Of Organic Chemistry Cd Nenitzescu

Bucharest, Romania

Institute Of Organic Chemistry Cd Nenitzescu

Bucharest, Romania
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Popa C.-V.,University of Bucharest | Lungu L.,Institute Of Organic Chemistry Cd Nenitzescu | Savoiu M.,Institute Of Organic Chemistry Cd Nenitzescu | Bradu C.,University of Bucharest | And 2 more authors.
International Journal of Food Properties | Year: 2012

Alcoholic extracts of six culinary and medicinal plants have been analyzed for their antioxidative properties. Extracts were obtained by continuous (Soxhlet) and ultrasounds extraction. A new flow injection analysis method with chemiluminescence detection based on a luminol/Co(II)/EDTA/H2O 2 system was set up for the total antioxidant capacity determination of the studied extracts. For comparison, total phenols and flavonoids contents of plant extracts were determined by spectrophotometric methods. A good correlation between total phenols and total antioxidant capacity was found for some determinations. © 2012 Copyright Taylor and Francis Group, LLC.


Stoica P.,Science I.C.P.E. Bistrita S.A | Stoica P.,University of Bucharest | Chifiriuc M.C.,University of Bucharest | Rapa M.,Science I.C.P.E. Bistrita S.A | And 9 more authors.
Romanian Biotechnological Letters | Year: 2015

The continuously spreading use of implantable medical devices (IMDs) in all fields of medicine increased the risk of microbial colonization leading to difficult to treat infections. The objective of this study was to obtain and characterize by physico-chemical and biological methods, new biopolymeric composites with anti-adherence properties based on polycaprolactone (PCL) dopped with chitosan (CS) and essential oils (EOs) as antimicrobial agents, for further use in the manufacture or coating of IMDs. The EOs were extracted from cinnamon (CIN), coriander (COR) and tea tree (TEA), and were characterized by GC-MS. Biopolymeric composite films (PCL/CS, PCL/CS/EOs) were obtained by solvent evaporation in two variants and further characterized by DSC and FTIR techniques. The in vitro antimicrobial activity of EOs was determined by the minimum inhibitory concentration (MIC) assay in liquid medium, towards Gram-positive and Gram-negative bacterial strains. The anti-adherence activity of films was analyzed against Staphylococcus aureus ATCC 29213 by viable cell counts assay. The cytotoxicity of the obtained films was assessed using the HT29 cell line. The results of this study suggest that CIN EO strongly inhibited the growth of all tested bacterial species, followed by TEA and COR EOs. From all tested composites, only PCL/CS/CIN1 exhibited a significant anti-adherence effect. © 2015 university of bucharest.


Razus A.C.,Institute Of Organic Chemistry Cd Nenitzescu | Nica S.,Institute Of Organic Chemistry Cd Nenitzescu | Nica S.,Petru Poni Institute of Macromolecular Chemistry | Cristian L.,Institute Of Organic Chemistry Cd Nenitzescu | And 3 more authors.
Dyes and Pigments | Year: 2011

Highly conjugated azo-aromatic systems have been prepared in high to moderate yields by linking mono- and bis-azo aromatic fragments to 4-(Rn-azulen-1-yl)-2,6-dimethyl-pyridine. The synthesized π-extended systems have been studied by NMR spectroscopy, UV-Vis and electrochemistry. Systematic increase of the conjugation along the azobenzene skeleton has affected the spectral properties of the azophenyl substituted 4-(azulen-1-yl)-pyridine. The synthesized compounds exhibit a bathochromic shift of the visible absorption maxima with the increase of the conjugating skeleton and introduction of an electron-withdrawing group. The electrochemical behavior revealed a high stability toward oxidation owing to the higher polarization induced by the azulenylpyridine moiety. © 2011 Elsevier Ltd. All rights reserved.


Razus A.C.,Institute Of Organic Chemistry Cd Nenitzescu | Dragu E.A.,Institute Of Organic Chemistry Cd Nenitzescu | Nica S.,Institute Of Organic Chemistry Cd Nenitzescu | Nica S.,Petru Poni Institute of Macromolecular Chemistry | Nicolescu A.,Petru Poni Institute of Macromolecular Chemistry
Tetrahedron Letters | Year: 2011

The azulen-1-yl group strongly influences the course of the TiCl 4-Zn promoted McMurry coupling of 1-acetylazulene which afforded, along with the normal coupling products, pinacol 2dl and alkene 3, the pinacolone 4. The latter was likely formed via rearrangement of the pinacolate intermediate. An improved, microwave-assisted protocol was developed for this reaction that provided high yields of products in a short reaction time. The steric reaction route is consistent with the proposed mechanism. © 2011 Elsevier Ltd. All rights reserved.

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