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Muna K.A.,International Islamic University Malaysia | Mokhtar A.,International Islamic University Malaysia | Saad M.A.,International Islamic University Malaysia | Ahmed A.A.,International Islamic University Malaysia | Akbar J.B.,Institute of Oceanography and Maritime Studies INOCEM
International Medical Journal Malaysia | Year: 2015

Introduction:Leptin is an adipokine that has strong correlation with the body mass index (BMI). Gestational diabetes mellitus (GDM) is a common medical complication associated with pregnancy. Leptin may lose its correlation with the body mass index (BMI) during diabetes due to hormonal rearrangement. Diet control is the first line management in GDM. Leptin reported to increase in pregnancy and further increases in diabetic patients during GDM screening. There is paucity in the reports concerning Leptin levels in GDM patients on diet control. The present study was aimed to evaluate the changes in maternal leptin in pregnancy complicated by GDM on diet control compared to the normal pregnancy in the 3rd trimesters by comparing the means and to find the correlation of Leptin with the body mass index in both groups. Methods: The study included 2 groups: normal pregnancy (n = 40) and pregnancy with GDM under diet control (n = 60) both groups are at 38-40 weeks of gestation. Leptin concentration in serum was measured in both groups and statistically tested using student t test. The BMI were measured and correlated with the Leptin level in test groups. Results: the results indicated that Leptin will nearly triple in the third trimester (38 ± 30 ng/ml) of pregnancy compared to the standard normal non-pregnant. Leptin level was significantly lower in diabetic women on diet control (28 ± 16 ng/ml) when compared with the non-diabetics (38 ± 30 ng/ml). The hormone has no correlation with the age of the patients but have a positive correlation with the body mass index before and during pregnancy in both groups. Conclusion: Leptin is increasing in pregnancy as part of the physiological changes. Dieting can decrease Leptin level in diabetics' pregnant women. Diet can restore the hormonal dysregulation of Leptin. Assessment of Leptin level might be used as an indicator for good diet control during pregnancy. Source


Faudzi F.,Kulliyyah of Science | Kamaruzzamanyunus,Kulliyyah of Science | Kamaruzzamanyunus,Institute of Oceanography and Maritime Studies INOCEM | Miskon M.,Kulliyyah of Science | Rahman M.,International Islamic University Malaysia
Oriental Journal of Chemistry | Year: 2014

The concentrations of toxic metals were determined in estuary and freshwater zones from Kuantan River basin. Water samples were collected from the surface and bottom layers of nine sampling stations, from the downstream of the estuary towards the upstream along the mainstream drainage channel, traversing past the city center and industries of Kuantan city. The general physico-chemical parameters (salinity, temperature, pH and dissolved oxygen) and concentration of total dissolved metals, Cadmium (Cd), Chromium (Cr) and Lead (Pb)were measured during dry season (May and June 2012) and wet season (September and October 2012). Metal concentration was determined using Inductively Coupled Plasma Mass Spectrometry (ICP-MS).Metal concentrations ranged from 0.299 - 1.815μg/Lfor Cr, undetectable to 0.034μg/L for Cd and 4.697 - 16.017μg/L for Pb, respectively. The present measurements can be used as a baseline data for any future monitoring and comparison of trace metals distribution in the Kuantan River. Source


Kamarudin K.R.,University of Auckland | Kamarudin K.R.,Institute of Oceanography and Maritime Studies INOCEM | Rehan A.M.,Institute of Oceanography and Maritime Studies INOCEM | Hashim R.,Institute of Oceanography and Maritime Studies INOCEM | Usup G.,National University of Malaysia
Malayan Nature Journal | Year: 2010

Sea cucumbers (Echinodermata: Holothuroidea) are regarded as an important part of Malaysia's marine heritage due to their diversity and commercial value. Several ecological studies have been conducted aimed at documenting the distribution of sea cucumbers in Malaysia. It is estimated that more than 80 species of sea cucumber are present in Malaysia. Nevertheless, a large number of undetermined species have been recorded, thus requiring further research to update the species identification. Molecular approaches are capable of providing insights into the phylogeny of sea cucumbers and can support the outcomes of traditional morphological approaches, and a number of molecular ecological studies have been recorded in Malaysia since 1999. Source


Zaleha K.,University of Malaysia, Terengganu | John A.,Institute of Oceanography and Maritime Studies INOCEM | John A.,International Islamic University Malaysia | Asgnari H.,University of Malaysia, Terengganu | And 2 more authors.
Malaysian Applied Biology | Year: 2014

Effect of various environmental stresses on the fatty acid (FA) profile of benthic harpacticoid copepod (Pararobertsonia sp.) was checked In vitro. Samples were exposed to different pH (5, 7 and 9) and salinity (15, 20, 25, 30 and 35 ppt) at constant temperature 25°C for 30 days. After the treatment, different fatty acid levels were determined using Gas Chromatography and Mass Spectrometry (GC-MS). Results clearly indicated the positive influence of the combined effect of environmental parameters on the fatty acid content in experimental samples. The detected FAs were ranging from C5-24. Palmetic and oleic acids were in higher percentage in all the experiments. Results clearly indicated that pH7:25ppt & 35ppt at 25°C ambient water temperature would help in producing copepods (Pararobertsonia sp.) that expresses rich fatty acid profile with high EPA/DHA ratio. Source


Jalal K.C.A.,Institute of Oceanography and Maritime Studies INOCEM | Jalal K.C.A.,International Islamic University Malaysia | John B.A.,Institute of Oceanography and Maritime Studies INOCEM | John B.A.,International Islamic University Malaysia | And 4 more authors.
Oriental Journal of Chemistry | Year: 2013

A study on Copper (Cu), Zinc (Zn) and Lead(Pb) concentration in fresh water fish Channastriatus -Haruan fish in Pahang, Malaysia was conducted. Three types of fish organs were studied. The organs were; liver, muscle and intestine. They were dissected and dried before the digestion process using HNO3, H2SO4, H2O2 and HCL. Inductively Coupled Plasma Spectrometry (ICP-MS) was used for the detection of heavy metals. There was a significant variation in the concentration of zinc was observed between tissues of the studied fish (P < 0.05) while copper and lead showed no significant difference in accumulation between selected tissues. Nevertheless, the findings from this study revealed that all the heavy metals concentrations in the tissues were lower than the maximum permissible limit as recommended by The Malaysian Food Regulation and hence safe for human consumption. Long term monitoring study is needed to implement various fishery management plans to safeguard the quality of C. striatuswild stock. Source

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