Institute of Occupational Health

Amsterdam, Netherlands

Institute of Occupational Health

Amsterdam, Netherlands
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Frings-Dresen M.H.W.,Institute of Occupational Health | Sluiter J.K.,Institute of Occupational Health
Disability and Rehabilitation | Year: 2011

Purpose: This study aimed to explore the perceived work ability of patients with postpoliomyelitis syndrome (PPS), to identify barriers and factors that are impeding or conducive, respectively, to work participation, and to identify possible interventions. Methods: Qualitative cross-sectional interview study with 17 subjects with PPS, 12 women and 5 men, mean age 49 years (SD: 11). Semi-structured interviews were held with the subjects in their homes, with the aid of a topic list. The COREQ criteria list for qualitative research was used as guideline in design and analysis. Results: Thirteen out of 17 subjects rated their work ability six or higher on a scale from 0 to 10. Most subjects worked in an administrative, educational or managerial function. Five subjects stopped working, four worked between 0 and 20h/week and eight worked between 20 and 40h/week. Factors conducive to working were physical adaptations in the workplace, accessibility of the workplace and high decision latitude. Barriers to full work ability in PPS patients were high physical job demands, low social support and the symptoms of PPS, especially fatigue and pain. Conclusions: These findings suggest that work-oriented interventions aimed at preventing PPS patients from dropping out of the workforce should primarily focus on reducing physical job demands, arranging adaptations in the workplace and increasing job control. © 2011 Informa UK, Ltd.

PubMed | Institute of Occupational Health, University of Novi Sad, Pharmacy Novi Sad and Institute of Laboratory Diagnostics
Type: | Journal: BMC complementary and alternative medicine | Year: 2015

Herbal supplements are widely used in the treatment of various liver disases, but some of them may also induce liver injuries. Regarding the infuence of thyme and its constituents on the liver, conflicting results have been reported in the literature. The objective of this study was to examine the influence of two commonly used pharmaceutical formulations containing thyme (Thymus vulgaris L.), tincture and syrup, on carbon tetrachloride-induced acute liver injury in rats.Chemical composition of investigated formulations of thyme was determined by gas chromatography and mass spectrometry. Activities of enzyme markers of hepatocellular damage in serum and antioxidant enzymes in the liver homogenates were measured using the kinetic spectrophotometric methods. Liver morphology was characterized by light microscopy using routine hematoxylin and eosin staining.Thymol was found to be predominant active constituent in both tincture and syrup. Investigated thyme preparations exerted antioxidant effects in liver by preventing carbon tetrachloride-induced increase of lipid peroxidation. Furthermore, co-treatment with thyme preparations reversed the activities of oxidative stress-related enzymes xanthine oxidase, catalase, peroxidase, glutathione peroxidase and glutathione reductase, towards normal values in the liver. Hepatotoxicity induced by carbon tetrachloride was reflected by a marked elevation of AST and ALT activities, and histopathologic alterations. Co-administration of thyme tincture resulted in unexpected exacerbation of AST and ALT values in serum, while thyme syrup managed to reduce activites of aminotransferases, in comparison to carbon tetrachloride-treated animals.Despite demonstrated antioxidant activity, mediated through both direct free radical scavenging and activation of antioxidant defense mechanisms, thyme preparations could not ameliorate liver injury in rats. Molecular mechanisms of diverse effects of thyme preparations on chemical-induced hepatotoxicity should be more in-depth investigated.

Sierevelt I.N.,Medical Center Slotervaart | Dijkgraaf M.G.,Clinical Research Unit | Frings-Dresen M.H.W.,Institute of Occupational Health
PLoS ONE | Year: 2016

Purpose: The aim of this study was to determine the cumulative effect of a routine (hot-to-) cold shower on sickness, quality of life and work productivity. Methods: Between January and March 2015, 3018 participantsbetween 18 and 65 years without severe comorbidity and no routine experience of cold showering were randomized (1:1:1:1) to a (hotto-) cold shower for 30, 60, 90 seconds or a control group during 30 consecutive days followed by 60 days of showering cold at their own discretion for the intervention groups. The primary outcomewas illness days and related sickness absence fromwork. Secondary outcomes were quality of life, work productivity, anxiety, thermal sensation and adverse reactions. Results: 79% of participants in the interventions groups completed the 30 consecutive days protocol. A negative binomial regression model showed a 29% reduction in sickness absence for (hot-to-) cold shower regimen compared to the control group (incident rate ratio: 0.71, P = 0.003). For illness days there was no significant group effect. No related serious advents events were reported. Conclusion: A routine (hot-to-) cold shower resulted in a statistical reduction of self-reportedsickness absence but not illness days in adults without severe comorbidity. © 2016 Buijze et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Spasojevic-Tisma V.D.,Public Company Nuclear Facilities of Serbia | Celeketic D.C.,Zemun Medical Center | Tisma J.M.,University of Belgrade | Milacic S.B.,Institute of Occupational Health | Papovic-Dukic G.V.,Health Center Vrbas
Nuclear Technology and Radiation Protection | Year: 2011

The study included 75 subjects exposed to low doses of external ionizing radiation and 25 subjects from the control group, all male. The first group (A) consisted of 25 subjects employed in the production of technetium, with an average job experience of 15 years. The second group (B) consisted of 25 subjects exposed to ionizing radiation from enclosed sources, working in jobs involving the control of X-ray devices and americium smoke detectors, their average work experience being 18.5 years. The third group (C) consisted of 25 subjects involved in the decontamination of the terrain at Borovac from radioactive rounds with depleted uranium left over after the NATO bombing of Serbia in 1999, their average job experience being 18.5 years. The control group (K) consisted of 25 subjects who have not been in contact with sources of ionizing radiation and who hold administrative positions. Frequencies of chromosome aberrations were determined in lymphocytes of peripheral blood and compared to the control group. The average annual absorbed dose determined by thermoluminescent dosimeters for all three groups did not exceed 2 mSv. In the present study, the largest number of observed changes are acentric fragments and chromosome breaks. The highest occupational risk appears to involve subjects working in manufacturing of the radioisotope technetium.

Manic V.,University of Niš | Nikezic D.,University of Kragujevac | Krstic D.,University of Kragujevac | Manic G.,Institute of Occupational Health
Radiation Protection Dosimetry | Year: 2014

The specific absorbed gamma dose rates, originating from natural radionuclides in concrete, were calculated at different positions of a detection point inside the standard room, as well as inside an example room. The specific absorbed dose rates corresponding to a wall with arbitrary dimensions and thickness were also evaluated, and appropriate fitting functions were developed, enabling dose rate calculation for most realistic rooms. In order to make calculation simpler, the expressions fitting the exposure build-up factors for whole 238U and 232Th radionuclide series and 40K were derived in this work, as well as the specific absorbed dose rates from a point source in concrete. Calculated values of the specific absorbed dose rates at the centre point of the standard room for 238U, 232Th and 40K are in the ranges of previously obtained data. © The Author 2014. Published by Oxford University Press. All rights reserved.

Minov J.,Institute of Occupational Health | Karadzinska-Bislimovska J.,Institute of Occupational Health | Vasilevska K.,Institute of Epidemiology and Biostatistics | Nelovska Z.,Institute of Occupational Health | And 3 more authors.
Arhiv za Higijenu Rada i Toksikologiju | Year: 2012

To assess the efficacy of nationwide anti-smoking campaign, we compared the findings of a study on worker smoking performed in 2005 with our latest cross-sectional study completed in 2010. It included 753 randomly selected workers, of whom 126 office, 108 construction, 93 agricultural, 97 petroleum refinery, 114 textile, 117 food processing workers, and 98 cleaners. Information was collected with a self-administered questionnaire. The prevalence of current smokers among all workers was 35.4 %, ranging from 30.2 % in office workers to 43.5 % in construction workers. It did not significantly differ from the prevalence recorded in 2005 (35.4 % vs. 36.8 %, respectively; P=0.441). Mean pack-years smoked among all smokers was 12.4±2.3, ranging from 10.9 in administrative workers to 13.7 in agricultural workers. We did not find any significant difference in the prevalence of current smokers between male and female workers and between workers aged less or more than 40 years, as well as between workers of higher and lower education. The prevalence of ex-smokers was 10.5 %, ranging from 8.4 % in construction workers to 12.1 % in administrative workers, whereas the prevalence of passive smokers was 29.1 %, ranging from 26.2 % in food processing workers to 32.9 % in agricultural workers. Our findings indicate that the prevalence of current and passive smokers has remained high regardless of the anti-smoking campaign and call for stricter implementation of anti-smoking regulations.

Work equipment and installations with a high risk for health and safety of employees should be paid a special attention. The German Product Safety Act, which is aimed to manufacturers or distributors in order to protect consumers, maintains a conclusive catalogue of these so-called "installations in need of monitoring" fixing the work equipment and installations for which such special inspections can be demanded. This catalogue has remained unchanged for decades and has been transformed nearly unmodified into the Plant Safety Ordinance. Currently, there is a discussion about this catalogue in Germany. A major point of concern is the definition and the significance of "especially" dangerous work equipment and installations. Two recent research projects are dealing with the problem how to define "especially". © 2012 - IOS Press and the authors. All rights reserved.

Manic V.,University of Niš | Manic G.,Institute of Occupational Health | Nikezic D.,University of Kragujevac | Krstic D.,University of Kragujevac
Radiation Protection Dosimetry | Year: 2012

The absorbed gamma dose rate in indoor air due to natural radionuclides in concrete as a building material was determined in this work. The dose rate conversion factors for 238U, 232Th and 40K, for standard rooms as well as rooms with different sets of dimensions, were evaluated by the point kernel technique, using Harima (geometric progression) build-up factors. The values of the conversion factors, in units (nGy h-1 (Bq kg. -1)-1) calculated for the standard room are: 0.76, 0.91 and 0.070, respectively for 238U, 232Th and 40K. The fitting formula was obtained for dose rate conversion factors, enabling them to be conveniently calculated for a room with arbitrary dimensions. For concrete block samples collected in the area of Niš, Serbia, the measurement of the radionuclide activity concentrations was also carried out. The evaluated absorbed dose rate conversion factors were then applied in the assessment of corresponding indoor gamma dose rates, finding that all the concrete samples fulfilled the usage requirement. © The Author 2012. Published by Oxford University Press. All rights reserved.

Gromadzinska J.,University of Lodz | Peplonska B.,University of Lodz | Sobala W.,University of Lodz | Reszka E.,University of Lodz | And 3 more authors.
International Archives of Occupational and Environmental Health | Year: 2013

Purpose: Light-at-night exposure can disrupt the human circadian rhythm via clock gene expressions. The circadian rhythm influences antioxidant enzymes' activity and cellular mRNA levels of these enzymes. The employees working based on a shift system adjust to the changes occurring both on the cell level and on the level of the whole organism. Therefore, a question should be answered whether shift work disturbs oxidant-antioxidant balance and/or generates oxidative stress. Methods: A cross-sectional study was conducted among nurses selected from the Local Registry of the Chamber of Nurses and Midwives in Lodz: 359 nurses worked daily only and 349 working rotating night shifts. These two groups differed significantly in respect of age (p < 0.0001), menopausal status (p < 0.0001), and current smoking habit (p = 0.02). The average total work duration was significantly shorter (12.4 years) in nurses working currently rotating night shifts who worked significantly longer on night shifts than day-workers (26.6 years). Results: We found statistically significant higher red blood cell glutathione peroxidase in nurses working on night shifts (21.0 ± 4.6 vs. 20.0 ± 5.0 U/g Hb, p < 0.009) after adjusting for age, oral contraceptive hormone use, smoking, and drinking alcohol during last 24 h. Statistically significant lower vitamin A and E levels were found in the premenopausal women working in rotating system (0.690 ± 0.238 vs. 0.786 ± 0.262 μg/ml, p < 0.0001 for vitamin A and 10.93 ± 4.15 vs. 12.78 ± 4.75 μg/ml, p < 0.0001 for vitamin E). The marker of lipid peroxidation (TBARS concentration) was significantly lower in the premenopausal nurses than postmenopausal ones working day shifts only (2.06 ± 0.76 vs. 2.21 ± 0.80 nmol/ml, p < 0.038). We observed that erythrocyte GSH-Px activity rose statistically significant in nurses working more night shifts per month (p < 0.01). Conclusions: The results quoted above seem to support the existence of an association between light-at-night exposure and blood glutathione peroxidase activity in female shift workers. Nevertheless, in order to explain the mechanisms of this association, we need more studies. © 2012 The Author(s).

Djindjic N.,University of Niš | Jovanovic J.,Institute of Occupational Health | Djindjic B.,Institute of Pathophysiology | Jovanovic M.,University of Niš | And 2 more authors.
Vojnosanitetski Pregled | Year: 2013

Background/Aim. Occupational stress is a term used to define ongoing stress that is related to the workplace. The study was conducted to determine association of occupational stress index (OSI) and its aspects with arterial hypertension and lipid disorders using data from a cross-sectional survey of male professional drivers. Methods. The cross-sectional study was performed in 439 professional drivers divided into groups (city- and intercity bus drivers, truck and taxi drivers). The OSI and OSI aspects (high demands, strictness, underload, extrinsic time pressure, noxious exposure, avoidance and conflict) were calculated using the standardized questionnaire. Determination of serum lipids, blood pressure (BP) and cardiovascular risk factors were done. Results. A significant difference in prevalence of diagnosed hypertension and dyslipidemia was found along with a difference in total OSI and OSI aspects among examined subgroups of drivers. A total OSI was highest in city, high in intercity bus drivers, and the lowest one in truck and taxi drivers (82.79 ± 3.5, 81.28 ± 3.7, 73.75 ± 3.5, 71.61 ± 4.4, respectively; p < 0.01). Similar pattern showed triglycerides (TG), total cholesterol (TC) and LDL cholesterol and BP, while HDL-cholesterol showed reverse order (p < 0.01). Logistic regression analyses with multiple OSI aspects adjusted for age and years of exposure showed associations of total OSI with arterial hypertension OR 5.5; 95% CI (2.24-7.95) and dyslipidemia OR 1.43 95% CI (1.09-2.80). Underload was the most important OSI aspect associated with the arterial hypertension OR 1.18; 95% CI (1.04-2.58) and elevated LDL cholesterol 1.26; 95 CI (1.19-2.1). A total OSI had a significant association with elevated LDL cholesterol 2.64; 95% CI (1.19- 7.7), triglycerides OR 3.27; 95% CI (1.20-5.1) and low HDL cholesterol OR 3.29; 95% CI (1.8-5.8) (p < 0.01). Conclusion. The study provides the evidence for the significant association of total OSI and underload with lipid disorders and elevated blood pressure in professional drivers, which could be a possible link between job stress and coronary heart disease. Regular periodical examinations and workplace interventions aimed to decrease total OSI and underload are important aspects in primary prevention and additional reduction of cardiovascular risk.

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