Institute of Occupational Disease Prevention

Nanjing, China

Institute of Occupational Disease Prevention

Nanjing, China

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Wang Z.,Jiangxi Agricultural University | Liu Z.,Institute of Occupational Disease Prevention | Wu X.,Jiangxi Agricultural University | Yan W.,Jiangxi Agricultural University | Zeng Z.,Jiangxi Agricultural University
Molecular Biology Reports | Year: 2012

The complementary sex determination (csd) gene is the primary gene determining the gender of honey bees (Apis spp). In this study we analyzed the polymorphism of csd gene in six Apis mellifera subspecies. The genomic region 3 of csd gene in these six A. mellifera was cloned, and identified. A total of 79 haplotypes were obtained from these six subspecies. Analysis showed that region 3 of csd gene has a high level of polymorphism in all the six A. mellifera subspecies. The A. m. anatolica subspecies has a slightly higher nucleotide diversity (π) than other subspecies, while the π values showed no significant difference among the other five subspecies. The phylogenetic tree showed that all the csd haplotypes from different A. mellifera subspecies are scattered throughout the tree, without forming six different clades. Population differentiation analysis showed that there are significant genetic differentiations among some of the subspecies. The NJ phylogenetic tree showed that the A. m. caucasica and A. m. carnica have the closest relationship, followed by A. m. ssp, A. m. ligustica, A. m. carpatica and A. m. anatolica that were gathered in the tree in turn. © Springer Science+Business Media B.V. 2011.


PubMed | Centers for Disease Control and Prevention, Nanjing Medical University, Institute of Occupational Disease Prevention and The First Peoples Hospital of Kunshan
Type: Journal Article | Journal: International archives of occupational and environmental health | Year: 2016

To investigate whether the apurinic/apyrimidinic endonuclease 1 (APE1) 1349 T>G and -656 T>G polymorphisms were associated with the risk of noise-induced hearing loss (NIHL) in a Chinese population.The two APE1 polymorphisms were analyzed among 613 NIHL workers and 613 normal hearing workers using the minor groove binder TaqMan probe assay.We found that the APE1 -656 TT genotype was associated with a increased risk of NIHL [adjusted odds ratio (OR) 1.46, 95% confidence interval (CI) 1.05-2.06]. This increased risk was more pronounced in the stratification analysis. Furthermore, we found that subjects with two risk genotypes (hOGG1 Cys/Cys, APE1 -656 TT) had a significantly increased risk of NIHL (adjusted OR 1.91, 95% CI 1.27-2.88).Our study identified that the APE1 -656 T>G polymorphism may contribute to the susceptibility of NIHL.


Zhu H.,Nanjing Southeast University | Sun G.,Nanjing Southeast University | Zhu B.,Institute of Occupational Disease Prevention
Journal of Thoracic Disease | Year: 2016

From August 1 to September 26, 2012, 30 workers who had the symptom of edema in both lower limbs were reported in Yancheng, Four severe edemas in both lower limbs workers were sent to the hospital, and one person of the workers died. The epidemiology investigation and laboratory testing (in the urine loading tests, the concentration of VB1 of the workers living in the factory for more than half of the year decreased far below the normal values) were conducted to explore the cause. Furthermore, after one-week intramuscular injection of thiamine treatment, the clinical symptoms of the workers had been improved greatly. Finally, the lake of the thiamine (VB1) was considered to be the reason of this incident. © Journal of Thoracic Disease. All rights reserved.


PubMed | Nanjing Medical University, Nanjing Southeast University, Institute of Occupational Disease Prevention and Soochow University of China
Type: Journal Article | Journal: International journal of environmental research and public health | Year: 2017

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PubMed | Institute of Occupational Disease Prevention and Nanjing Southeast University
Type: Journal Article | Journal: Journal of thoracic disease | Year: 2016

From August 1 to September 26, 2012, 30 workers who had the symptom of edema in both lower limbs were reported in Yancheng, Four severe edemas in both lower limbs workers were sent to the hospital, and one person of the workers died. The epidemiology investigation and laboratory testing (in the urine loading tests, the concentration of VB1 of the workers living in the factory for more than half of the year decreased far below the normal values) were conducted to explore the cause. Furthermore, after one-week intramuscular injection of thiamine treatment, the clinical symptoms of the workers had been improved greatly. Finally, the lake of the thiamine (VB1) was considered to be the reason of this incident.


Ren R.,Harbin Medical University | Zhang Y.,Harbin Medical University | Lee B.,Institute of Occupational Disease Prevention | Wu Y.,Harbin Medical University | Li B.,Harbin Medical University
Journal of Cellular Biochemistry | Year: 2011

The aim of this study was to assess the effect of the β-amyloid fragment Aβ25-35 on mitochondrial structure and function and on the expression of proteins associated with the mitochondrial permeability transition pore (MPTP) in rat hippocampal neurons. Ninety clean-grade Sprague-Dawley rats were randomly assigned to six groups (n = 15 per group). Aβ25-35 (1, 5, or 10 Âμg/rat) was injected into hippocampal area CA1. Normal saline was injected as a control. The effect of Aβ25-35 injection on hippocampal structure was assessed by transmission electron microscopy. Ca2+-ATPase activity, [Ca 2+]i, and mitochondrial membrane potential were measured. The expression of genes associated with the MPTP, including the voltage-dependent anion channel (VDAC), adenine nucleotide translocator (ANT), and cyclophilin D (Cyp-D), were evaluated. Results showed that Aβ25-35 injection damaged the mitochondrial structure of hippocampal neurons, decreased Ca2+-ATPase activity and mitochondrial membrane potential, and increased [Ca2+]i. The expression levels for VDAC, ANT, and Cyp-D in all groups were significantly (P < 0.05) higher than those in the normal control group after Aβ25-35 injection. These results indicate that Aβ25-35 damages mitochondria in rat hippocampal neurons and effects mitochondrial dysfunction, as well as increasing the expression of genes associated with the MPTP. Mitochondrial dysfunction may result in increased MPTP gene expression, leading to neurodegenerative effects. © 2011 Wiley-Liss, Inc.


Gong W.,Institute of Occupational Disease Prevention | Liu X.,Institute of Occupational Disease Prevention | Zhu B.,Institute of Occupational Disease Prevention
Journal of Thoracic Disease | Year: 2016

In recent years, N,N-dimethylacetamide (DMAc) is widely used in the textile and plastics industry as a solvent alternative to more toxic N,N-dimethylformamide (DMF). At home and abroad, sporadic group case reports have revealed that DMAc could cause toxic hepatitis and symptoms or signs indicative of liver involvement among workers exposed to DMAc, with severe cases leading to death. This paper reports a rare case of severe acute toxic hepatitis with a short term recurrence induced by occupational contact with DMAc in a polyimide film factory, as well as in-depth analysis via relevant information and literature.


PubMed | Institute of Occupational Disease Prevention
Type: Journal Article | Journal: Journal of thoracic disease | Year: 2016

Tetraethyl lead (TEL) poisoning has declined sharply with decreasing consumption of gasoil and other chemicals contained TEL. Here we reported group TEL poisoning in the plastic weaving factory. We investigated 16 cases with the typical nerves disorder which is similar to organotin poisoning, and the result suggested that the poisoning may cause by applied white oil contented TEL. Despite its rareness, our cases emphasize that clinicians should pay attention to the difference from the treatment of organic tin poisoning.


PubMed | Institute of Occupational Disease Prevention
Type: Journal Article | Journal: Journal of thoracic disease | Year: 2016

In recent years, N,N-dimethylacetamide (DMAc) is widely used in the textile and plastics industry as a solvent alternative to more toxic N,N-dimethylformamide (DMF). At home and abroad, sporadic group case reports have revealed that DMAc could cause toxic hepatitis and symptoms or signs indicative of liver involvement among workers exposed to DMAc, with severe cases leading to death. This paper reports a rare case of severe acute toxic hepatitis with a short term recurrence induced by occupational contact with DMAc in a polyimide film factory, as well as in-depth analysis via relevant information and literature.


PubMed | Institute of Occupational Disease Prevention
Type: Journal Article | Journal: Biomedical and environmental sciences : BES | Year: 2016

N,N-Dimethylacetamide (DMAc) is a widely used organic solvent in modern chemical industry with low to moderate hepatotoxicity to occupational health of employees. But so far, there are fewer and less conclusive data concerning its pathogenic mechanism in detail. In current study, the toxicity of DMAc was firstly investigated on human normal hepatocytes (LO-2), using a series of molecular biology measurements to ananlyze the effect and mechanism of DMAc-induced hepatic cell injury and explore effective prophylactic measures. We found that DMAc triggered LO-2 apoptosis in a obviously dose-dependent manner, caused by increased ROS generation and activation of Bcl-2 pathway. Significantly, glutathione (GSH) rather than vitamin C (Vit C) could partially inhibit DMAc-induced apoptosis thus showing potential as a effective precaution for workers.

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