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Vera-Ramirez L.,Complejo Hospitalario Of Jaen | Vera-Ramirez L.,Institute of Nutrition and Food Technology Jose Mataix Verdu | Sanchez-Rovira P.,Complejo Hospitalario Of Jaen | Ramirez-Tortosa C.L.,Complejo Hospitalario Of Jaen | And 7 more authors.
Cancer Treatment Reviews | Year: 2010

During the past decade, several high throughput analytical methods for gene-expression profiling have been developed. DNA microarrays and multiplex RT-PCR have been applied in the field of breast-cancer research to establish new molecular taxonomic classifications, or a selected group of genes able to predict the prognosis of the patients and/or their response to chemotherapy. This technology provides an opportunity to refine the anti-neoplastic treatment and avoid the currently observed under- and over-treatment of breast-cancer patients. In parallel, high throughput technologies for gene-expression analysis have been applied to research on cancer stem cells (CSCs) and the tumor microenvironment, offering a wider vision of the molecular processes that influence carcinogenic events, disease development, and the response to the treatment of breast-cancer patients. In this report, we briefly revisit the most relevant genomic studies on breast-cancer prognosis and prediction to introduce the latest advances in tumor dormancy, its implications in the clinical outcome of disease-free patients and its connection with CSCs biology and microenvironment influence in the metastatic process. Finally, we have discussed the contribution of the results of these studies to the design of new experimental strategies oriented towards personalized medicine. © 2010 Elsevier Ltd.

Vera-Ramirez L.,Complejo Hospitalario Of Jaen | Ramirez-Tortosa M.C.,Institute of Nutrition and Food Technology Jose Mataix Verdu | Ramirez-Tortosa M.C.,University of Granada | Sanchez-Rovira P.,Complejo Hospitalario Of Jaen | And 6 more authors.
Critical Reviews in Food Science and Nutrition | Year: 2013

Breast cancer, which presents the highest global incidence of all female cancers, is caused by the interaction of genetic and environmental factors. Among the latter, diet has attracted considerable attention, as it is a modifiable risk factor and thus offers an opportunity to design preventive strategies. Nevertheless, only alcohol consumption has been unequivocally related to increased breast cancer risk. Despite the failure of observational studies in human populations to clearly define the nature of the relationship between specific nutrient exposures and breast cancer risk, in vivo and in vitro studies strongly suggest its existence. Moreover, studies at the molecular level have identified the putative action mechanism by which the nutritional constituents of specific foodstuffs may exert protective or enhancing effects with respect to breast cancer risk. The inadequate experimental design of some observational studies, or the occurrence of measurement errors and/or recall bias during data collection, or insufficient follow-up and subject characterization, may underlie these controversies. By improving the methods used to study the relationship between diet and breast cancer risk, and by applying new technologies linked to novel approaches such as "nutrigenomics," it might be possible to derive effective recommendations for breast cancer prevention and thus improve anti-cancer treatment. © 2013 Copyright Taylor and Francis Group, LLC.

Roche E.,University Miguel Hernández | Ramirez-Tortosa C.L.,Complejo Hospitalario Of Jaen | Arribas M.I.,University Miguel Hernández | Ochoa J.J.,Institute of Nutrition and Food Technology Jose Mataix Verdu | And 11 more authors.
Journals of Gerontology - Series A Biological Sciences and Medical Sciences | Year: 2014

An adequate pancreatic structure is necessary for optimal organ function. Structural changes are critical in the development of age-related pancreatic disorders. We aimed to study the effect of oil consumption on pancreas histology in order to find aging-related signs. To this end, three groups of rats were fed an isocaloric diet for 2 years, where virgin olive, sunflower, or fish oil was included. Pancreatic samples for microscopy and blood samples were collected at the moment of sacrifice. As a result, the sunflower oil-fed rats presented higher β-cell numbers and twice the insulin content than virgin olive oil-fed animals. In addition, rats fed with fish oil developed acinar fibrosis and macrophage infiltrates in peri-insular regions, compared with counterparts fed with virgin olive oil. Inflammation signs were less prominent in the sunflower group. The obtained data emphasize the importance of dietary fatty acids in determining pancreatic structure. © 2013 The Author.

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