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Guo C.-H.,Hungkuang University | Liu P.-J.,Nutrition and Naturopathic Center | Liu P.-J.,Hungkuang University | Lin K.-P.,Hungkuang University | And 3 more authors.
Alternative Medicine Review | Year: 2012

OBJECTIVE: To examine the effects of nutritional supplement therapy on oxidant-antioxidant status, inflammation and immune system responses, pulmonary function, and health-related quality of life in patients with mild to moderate allergic asthma. METHODS: Adult asthma patients (n=30) received daily multiple nutrient supplements for two months. Age- and gender-matched healthy controls (n=30) did not receive any supplements. Enzymatic and non-enzymatic antioxidant status, malondialdehyde (MDA), high-sensitivity C-reactive protein (hs-CRP), immunoglobulin E (IgE) and T-lymphocyte subsets, pulmonary function indices, as well as scores for asthma control and quality of life, were assessed at baseline, at one month of treatment, and at two months of treatment, which was also the end of the study. RESULTS: At baseline, asthma patients had significantly higher IgE, MDA, copper (Cu), hs-CRP, and CD19 and CD4/CD8 lymphocyte ratios, and decreased selenium (Se), zinc (Zn), β-carotene, vitamins C and E, and catalase, glutathione peroxidase (GPx) and glutathione reductase (GR) activities compared to healthy controls (p < 0.05). During the study period, asthmatics showed non-significantly increased pulmonary function and a trend toward lower IgE levels, markedly reduced MDA, Cu, hs-CRP, and CD19 and CD4/CD8 ratios, and increases in levels of Se, Zn, β-carotene, vitamins C and E, and enzymatic antioxidant activities. Also, their asthma control and health-related quality-of-life scores increased significantly by the end of the study. CONCLUSION: Our results indicate that nutritional supplement therapy may improve dysregulated oxidant and antioxidant status, inflammation and immune responses, pulmonary function, and health-related quality of life in patients with mild to moderate allergic asthma. Copyright © 2012 Alternative Medicine Review, LLC. All Rights Reserved. Source

Tsai C.-H.,Nutrition | Tsai C.-H.,Institute of Biomedical Nutrition | Tsai C.-H.,University of Hong Kong | Wang H.-F.,Institute of Biomedical Nutrition | And 5 more authors.
Nutritional Sciences Journal | Year: 2013

The autoantibodies That only appeal in type 1 diabetes mellnus CHDM also appeal in about 3.6% ~ 13.% of type 2 diabetes mellitus 12DM patients, and ihis disease is known as latent autoimmune diabetes- in adults LADA and is also called type 1.5 diabetes mellitus. the progression of autoimmune β-Ceil failuie in LADA is slower than that of T1DM; therefore, insulin is not required at least during the first several months after a diagnosis of diabetes, and lifestyle modifications can initially be used to oontiol glucose levels. Unfortunately, oral hypoglycemic agents and insulin are needed after several months to years. Progression of symptoms of L1DM, such as weight loss, a tendency to ketosis, unstable glucose control, and decieased (C-peptide, occurs later there currently are no standaid diagnosis or tieatment. Differences of LADA with T1DM and T2DM and ihe man agement of LADA are discussed. Source

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