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Mirzaei S.,Institute of Nuclear Medicine with Center
Torture : quarterly journal on rehabilitation of torture victims and prevention of torture | Year: 2012

The aim of this study is to evaluate the role of functional imaging for forensic purposes. We reviewed a few outpatient cases that were sent to our department for examination after traumatic events and one case with neuropsychic disturbances. Functional imaging showed signs of traumatic lesions in the skeletal system, of brain metabolism and of renal failure. Functional disturbances following traumatic events are in some cases more important than morphological abnormalities. Targeted scintigraphic examinations could be applied for visualisation of traumatic lesions or evaluation of functional disturbances caused by traumatic events. These examinations can be used as evidence in the courtroom.

Mirzaei S.,Institute of Nuclear Medicine with Center
Torture : quarterly journal on rehabilitation of torture victims and prevention of torture | Year: 2011

While there are some examples of legal cases which have resulted in the prosecution of perpetrators and successful reparation for survivors, in countries such as Iran such due procedure is close to impossible since torture is practiced by state officials mostly based on religious codes, and the legal system is controlled by practices that makes it close to impossible to achieve justice. This article discusses the implications of such a situation that also include health care professionals in third party countries who have an obligation to document evidence using the Istanbul Protocol based on a case example of a survivor exposed to different forms of torture.

Pestitschek M.,Institute of Nuclear Medicine with Center | Pestitschek M.,University of Vienna | Sonneck-Koenne C.,Institute of Nuclear Medicine with Center | Zakavi S.R.,Mashhad University of Medical Sciences | And 3 more authors.
Wiener Klinische Wochenschrift | Year: 2013

The present study was undertaken to estimate the selenium intake of thyroid patients and investigate the possible relation between thyroid abnormalities and the selenium intake. Methods The selenium intake through foods and the nutritional habits of thyroid patients in general were analyzed. Total 212 subjects from thyroid outpatient clinic of two state hospitals were interviewed. Among 212 subjects, 21 had no thyroid abnormality and served as controls. A food frequency questionnaire (FFQ) was developed to define the individual selenium intakes. From five different food groups, a total of 15 selenium-rich foods were selected, which are obtainable in Austria. The clinical and nutritional data were analyzed. Results Animal products such as milk and meat (pork, beef and poultry) played the most important role for the selenium supply in the Austrian diet. The intake of selenium in 86 % of the total study population was below the estimated average requirement (EAR). The selenium level was higher in euthyroid people compared with hypothyroid patients. Conclusions The developed FFQ is a tool to estimate the selenium intake in individuals, as it could be shown in this study. A significant positive correlation between selenium intake and blood selenium level was noted. These results must be confirmed by further studies in larger patient population.

Ahmadzadehfar H.,Institute of Nuclear Medicine with Center | Rodrigues M.,Institute of Nuclear Medicine with Center | Zakavi R.,Mashhad University of Medical Sciences | Knoll P.,Institute of Nuclear Medicine with Center | Mirzaei S.,Institute of Nuclear Medicine with Center
Medical Oncology | Year: 2011

Metabolic imaging with F-18-fluorodeoxyglucose ( 18F-FDG) positron-emission tomography (PET) is widely used for staging and treatment evaluation of malignant lymphoma. To date, only a few studies have indicated that lower glucose metabolism measured by 18F-FDG PET before or early in the course of treatment of malignant lymphoma is associated with a favorable outcome. The aim of this study was to assess the prognostic capability of the 18F-FDG PET maximum standardized uptake value (SUV max), a semiquantitative measurement of glucose metabolism, at the time of diagnosis of malignant lymphoma. We retrospectively analyzed data from 69 patients (median age: 61 and range 23-80) with malignant lymphoma (22 patients with Hodgkin's disease [HD] and 47 patients with Non-Hodgkin's lymphoma [NHL]) who had not received treatment before 18F-FDG PET imaging. Metabolic remission according to PET results was observed after chemotherapy in 50 patients (72.5%), while progressive disease or relapse was diagnosed in 19 patients (27.5%). Clinical follow-up revealed relapse in 4/50 patients with prior metabolic remission. A significantly lower (P < 0.01) baseline SUV max level (median: 4.6 and range 1.5-12.9) was found in patients with subsequent metabolic and clinical response than in those with progressive or relapsing disease (median SUV max 10.4, range 2.0-17.9). Thirty-seven of thirty-nine patients with baseline SUV max < 7.4 achieved long-lasting remission after completion of chemotherapy (median follow-up: 28 months, range 4-112 months). Within this group with favorable outcome, there were no significant differences between SUV max values in HD and NHL. A heterogeneous outcome was noted in 25 patients with a SUV max ≥ 7.4 and ≤ 12.9 at diagnosis, with 16 patients experiencing disease progression or relapse and nine patients extended remission. The five patients with SUV max > 12.9 showed disease progression at follow-up. Semiquantitative measurement of glucose metabolism (SUV max) by 18F-FDG PET at diagnosis is a predictor of outcome of patients with malignant lymphoma. © 2010 Springer Science+Business Media, LLC.

Mirzaei S.,Institute of Nuclear Medicine with Center | Bastati B.,Institute of Nuclear Medicine with Center | Lipp R.W.,Medical University of Graz | Knoll P.,Institute of Nuclear Medicine with Center | And 2 more authors.
Oncology | Year: 2011

Objective: Peptide receptor-targeted radionuclide therapy (PRRT) of somatostatin receptor (SR)-expressing neuroendocrine tumors (NETs) has become an established therapeutic option in patients with advanced NETs. The aim of this study was to compare the lesion detection rate of 99mTc-EDDA/HYNIC- TOC, a newly developed tracer for NET imaging, with 177Lu-DOTATATE used for PRRT. Methods: 8 patients (4 women, 4 men, age range 46-76 years) with histologically proven NETs, who showed high SR loads by 99mTc-EDDA/ HYNIC-TOC scintigraphy, were treated with 177Lu-DOTATATE. After treatment, all patients were subjected to whole-body scintigraphy with additional low-dose single-photon emission computed tomography (SPECT-CT) of the chest and abdomen. Results: All patients demonstrated 177Lu-DOTATATE accumulation in all lesions previously detected by 99mTc- EDDA/HYNIC-TOC scintigraphy. Three patients showed additional lesions in the liver and lungs. Conclusions: SPECT-CT after 177Lu-DOTATATE therapy may be helpful in detecting additional lesions not seen using 99mTc-EDDA/HYNIC-TOC. This could reflect the broader affinity of 177Lu-DOTATATE for SRs compared with 99mTc-EDDA/HYNIC-TOC. Copyright © 2011 S. Karger AG, Basel.

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