Institute of Nuclear Energy Research of Taiwan

www.iner.gov.tw/html/00_English/
Taoyuan, Taiwan
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Patent
Institute of Nuclear Energy Research of Taiwan | Date: 2017-06-28

The present invention provides a method for preparing a 6-aminohexyl lactoside-NOTA conjugate. The preparation method comprises brominating perbenzoylated lactose with hydrobromic acid; glycosylating 6-azidohexanol to obtain 6-azidohexyl perbenzoyl lactoside; and deprotecting this precursor in two steps to obtain 6-aminohexyl lactoside and conjugating 6-aminohexyl lactoside to NCS-benzyl-NODA GA (i.e. 2,2-(7-(1-carboxy-4-((4-isothiocyanate benzyl) amino)-4-oxobutyl)-1,4,7-triazonane-1,4-diyl) diacetic acid) in triethyl amine as an alkaline solvent, to obtain a 6-aminohexyl lactoside-NCS-benzyl-NODA GA conjugate. In this novel preparation method, no deglycosylated side product is produced, such that the yield is considerably increased to 46%. Therefore, the method is suitable for future massive production since the requirement for repeated preparations for massive production is reduced, and the impurities produced in the previously scaled-up preparation process are not present.


Patent
Institute of Nuclear Energy Research of Taiwan | Date: 2017-02-15

A flow battery apparatus is provided with shunted currents repressed. The apparatus has a positive electrode device, a negative electrode device and a plurality of gas-gap devices. Gas-gap devices are separately set between branching channels and inlet and outlet manifolds of positive and negative electrodes. Each of the branching channels separately has an inserting tube to be inserted into one of the gas-gap devices. The diameter of the inserted vessel of gas-gap devices is bigger than the diameter of the inserting tube connected to a corresponding one of the branching channels. Thus, working liquids transferred to the positive and negative electrodes are segregated with coordination of the gas-gap devices. Only air spaces and discrete liquid drops are left between separated parts of the working liquids. Thus, shunted currents are repressed by preventing conductive paths from being formed between the positive and negative electrodes.


Patent
Institute of Nuclear Energy Research of Taiwan | Date: 2016-05-18

Disclosed herein is a bispecific peptide conjugate comprising an epidermal growth factor receptor (EGFR) targeting peptide, an av3 integrin targeting peptide, and a linker, where the linker is conjugated respectively to the EGFR targeting peptide and the av3 integrin targeting peptide.


Patent
Institute of Nuclear Energy Research of Taiwan | Date: 2016-07-29

The present invention relates to a novel use of N-(4-isopropylphenyl)-5-amino-isoindoline for diagnosing Alzheimers disease and quantifying amyloid in the brain.


Patent
Institute of Nuclear Energy Research of Taiwan | Date: 2016-04-13

The present invention relates to a roll-to-roll hybrid plasma modular coating system, which comprises: at least one arc plasma processing unit, at least one magnetron sputtering plasma processing unit, a metallic film and at least one substrate feeding unit. Each of the arc plasma processing unit is formed with a first chamber and an arc plasma source. Each of the magnetron sputtering plasma processing unit is formed with a second chamber and at least one magnetron sputtering plasma source. The metallic film is disposed in the arc plasma processing unit to avoid chamber wall being deposited by the arc plasma source; There are at least one arc plasma processing unit, at least one magnetron sputtering plasma processing unit and at least one winding/unwinding unit connected in series to lay at least one thin layer by arc plasma deposition or by magnetron sputtering plasma onto substrate material.


Patent
Institute of Nuclear Energy Research of Taiwan | Date: 2016-07-11

A flow battery apparatus is provided with shunted currents repressed. The apparatus has a positive electrode device, a negative electrode device and a plurality of gas-gap devices. Gas-gap devices are separately set between branching channels and inlet and outlet manifolds of positive and negative electrodes. Each of the branching channels separately has an inserting tube to be inserted into one of the gas-gap devices. The diameter of the inserted vessel of gas-gap devices is bigger than the diameter of the inserting tube connected to a corresponding one of the branching channels. Thus, working liquids transferred to the positive and negative electrodes are segregated with coordination of the gas-gap devices. Only air spaces and discrete liquid drops are left between separated parts of the working liquids. Thus, shunted currents are repressed by preventing conductive paths from being formed between the positive and negative electrodes.


Patent
Institute of Nuclear Energy Research of Taiwan | Date: 2016-01-06

A method for manufacturing polycrystalline electrode is provided, which may include the following steps: providing a conductive substrate; using a film coating method to deposit an active material on one side of the conductive substrate by a hydrogen-containing plasma source to form an electrode layer; executing a thermal annealing process for the electrode layer in an oxygen-containing environment. The grains of the polycrystalline electrode manufactured by the method will be more uniform in size, which can significantly increase the volumetric energy density of thin-film battery to significantly improve its performance.


Patent
Institute of Nuclear Energy Research of Taiwan | Date: 2016-04-13

A double-sided all-solid-state thin-film lithium battery is provided, which may include a conductive substrate, a first upper electrode layer, a second upper electrode, an upper electrolyte layer, an upper current collecting layer, a first lower electrode layer, a second lower electrode layer, a lower electrolyte layer and a lower current collecting layer. The first upper electrode layer may be disposed at one side of the conductive substrate. The upper electrolyte layer may be disposed between the first and the second upper electrode layer. The upper current collecting layer may be disposed at one side of the second upper electrode layer. The first lower electrode layer may be disposed at the other side of the conductive substrate. The lower electrolyte layer may be disposed between the first and the second lower electrode layer. The lower current collecting layer may be disposed at one side of the second lower electrode layer.


Patent
Institute of Nuclear Energy Research of Taiwan | Date: 2017-05-10

The invention provides a metal-supported solid oxide fuel cell comprising a permeable metal substrate (200) and its manufacturing method. The permeable metal substrate (200) includes a substrate body (20) and a permeable powder layer (260). The permeable powder layer (260) is located on the top of the substrate body (20). The substrate body (20) can be a thick substrate (110) or formed of a thick substrate (110) and a thin substrate (230) that are welded together. Both the thick (110) and thin (230) substrates have a plurality of permeable straight gas channels (112, 232). In addition its manufacturing method is provided.


Patent
Institute of Nuclear Energy Research of Taiwan | Date: 2017-09-20

The invention provides a manufacturing method of a metal-supported solid oxide fuel cell (50) comprising a permeable substrate (200). The method comprises the steps of:providing a substrate body (S20);forming a plurality of gas channels (112) on the substrate body by using a drilling process (S21);forming a permeable powder layer (260) on the substrate body (S22) by using further steps of:forming a green layer (of permeable powder layer (260) by a tape caster, sintering the green layer into a permeable powder layer (260) by using a high temperature sintering process, disposing the sintered permeable powder layer (260) onto the substrate body and making them laminated and connected together by using high temperature pressing process;reducing the surface pore sizes of the permeable powder layer (260) to be smaller than 30 m (S24) ;using a high temperature pressing process (S25) to flatten a permeable metal substrate (200);and using an atmospheric plasma spraying process (S26) to sequentially form a porous anode layer (52), a dense anode isolation layer (53), a dense electrolyte layer (54), a dense cathode isolation layer (55) and a porous cathode layer (56) on the permeable metal substrate (100, 200).

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