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Kaifeng, China

Zottoli S.J.,Williams College | Zottoli S.J.,National Oceanic and Atmospheric Administration | Zottoli S.J.,Institute of Neurobiology
Neuroscientist | Year: 2012

The description of ionic currents that flow across the membrane of the squid giant axon during an action potential sparked an interest in determining whether there were similar currents in vertebrates. The preparation of choice was the node of Ranvier in single myelinated fibers in frog. José del Castillo spent 3 years on the United States mainland from 1956 to 1959. During that time, he collaborated with Jerome Y. Lettvin and John W. Moore. I discuss how these individuals met one another and some of their scientific discoveries using the voltage clamp to study squid giant axons and frog nodes. Much of this work was conducted at the Marine Biological Laboratory in Woods Hole, MA, and I attempt to convey a sense of the unique scientific "melting pot" that existed at the Marine Biological Laboratory and the broader effect that del Castillo had on "modern" neuroscience. © 2012 The Author(s). Source

Pallas M.,Deparment of Pharmacology and Medical Chemistry | Ortuno-Sahagun D.,University of Guadalajara | Andres-Benito P.,Deparment of Pharmacology and Medical Chemistry | Ponce-Regalado M.D.,Institute of Neurobiology | And 2 more authors.
Frontiers in Bioscience - Landmark | Year: 2014

Resveratrol has been extensively investigated and has been demonstrated to have antioxidant properties, cancer chemopreventive activity, and the capacity to modulate the hepatic synthesis of triglycerides and cholesterol, among others well established actions. A noteworthy feature of resveratrol is its ability to cross the blood-brain barrier and to exhibit neuroprotective actions, mainly by their capacity to regulate redox pathways as well as the Sirtuin (SIRT) system, which in turn modulates gene transcription, controlling inflammation and apoptosis in the brain. Lately, evidence is accumulating with respect to the synergic effect of resveratrol with antiepileptic drugs and also its antiepileptic activity in various models of seizures. We discuss here recent evidence that strongly suggests that resveratrol acts as an anticonvulsant agent and could be a very effective method for reducing damage in neural tissue and even for preventing seizure development in coadjuvant antiepileptic therapy. Source

Palmer M.S.,Gothenburg University | Skoog I.,Gothenburg University | Minthon L.,Lund University | Wallin A.,Gothenburg University | And 4 more authors.
NeuroMolecular Medicine | Year: 2010

The vascular hypothesis of Alzheimer's disease (AD) has brought the vascular endothelial growth factor (VEGF) into focus. The genomic region including the VEGF gene has been linked to AD and single nucleotide polymorphisms (SNPs) of the VEGF have in previous studies been associated with AD risk. To further evaluate these findings, we genotyped two SNPs in the VEGF gene (rs699947 [-2578]) and rs1570360 [-1154]) by TaqMan Allelic Discrimination in a study sample including AD patients (n = 801) and controls (n = 286). In a subgroup of the population these SNPs were analyzed in relation to APOE ε4 genotype, to cerebrospinal fluid biomarkers (T-tau, P-tau, and β42-Amyloid) as well as to neuropatho-logical markers for AD (neurofibrillary tangles and senile plaques). No significant associations with risk for AD or any of the studied biomarkers could be found in this study, thus not supporting VEGF as being a major risk gene for AD. © Humana Press Inc. 2009. Source

He S.,Sloan Kettering Cancer Center | Li Z.,Sloan Kettering Cancer Center | Ge S.,SUNY at Stony Brook | Yu Y.-C.,Institute of Neurobiology | Shi S.-H.,Sloan Kettering Cancer Center
Neuron | Year: 2015

Neocortical excitatory neurons migrate radially along the glial fibers of mother radial glial progenitors (RGPs) in a birth-date-dependent inside-out manner. However, the precise functional significance of this well-established orderly neuronal migration remains largely unclear. Here, we show that strong electrical synapses selectively form between RGPs and their newborn progeny and between sister excitatory neurons in ontogenetic radial clones at the embryonic stage. Interestingly, the preferential electrical coupling between sister excitatory neurons, but not that between RGP and newborn progeny, is eliminated in mice lacking REELIN or upon clonal depletion of DISABLED-1, which compromises the inside-out radial neuronal migration pattern in the developing neocortex. Moreover, increased levels of Ephrin-A ligand or receptor that laterally disperse sister excitatory neurons also disrupt preferential electrical coupling between radially aligned sister excitatory neurons. These results suggest that RGP-guided inside-out radial neuronal migration facilitates the initial assembly of lineage-dependent precise columnar microcircuits in the neocortex. He et al. show that electrical synapses preferentially form between progenitor and newborn progeny, and between sister excitatory neurons, in the embryonic neocortex. Moreover, disruption of the birth-date-dependent inside-out radial migration impairs preferential electrical coupling between sister excitatory neurons. © 2015 Elsevier Inc. Source

Kalueff A.V.,Tulane University | Kalueff A.V.,ZENEREI Institute | Stewart A.M.,Tulane University | Kyzar E.J.,Tulane University | And 16 more authors.
Behaviour | Year: 2012

Widely used in biomedical research, zebrafish (Danio rerio) are steadily gaining popularity as a model organism for studying neurobehavioral phenomena. Here, we focus on to the growing spectrum of zebrafish behavioral phenotypes and the 'bigger' biological problems these models help to address. Emphasizing the developing potential of zebrafish as a model organism in biological psychiatry, we discuss several questions related to this field: Do zebrafish have 'emotional'-like behaviors? What are their neural circuits, biomarkers, and ontogenetic origins? And, finally, how can we use this knowledge to build translational bridges to understand human emotions, motivation and personality? Representing a joint effort of several established neurobehavioral laboratories, this article outlines the mounting evidence to support emotionality in zebrafish and other fishes. This conclusion is important to justify the validity of zebrafish 'affective' paradigms and their utility for basic/translational research of normal and pathological behaviors. © 2012 Koninklijke Brill NV, Leiden. Source

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