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Bangalore, India

Kowsalya R.,Institute of Nephrourology | Sreekantha,Manipal University India | Chandran V.,Manipal University India | Remya,NITTE University
International Journal of Pharma and Bio Sciences | Year: 2011

Rheumatoid arthritis is a clinical condition accompanied by inflammation and oxidative stress. In this study, we compared levels of antioxidants vitamin-E and C along with lipid profile between rheumatoid arthritis patients and healthy controls. We also looked into presence of any correlation between dyslipidemia, the antioxidants vitamins and lipid peroxide product among rheumatoid arthritis patients. We found a significant fall in vitamin E and C along with raised MDA in patients compared to controls. A highly significant positive correlation was found between MDA and LDL-cholesterol (r = 0.781,P< 0.004),whereas vitamin E and C were negatively associated with MDA level (r = -0.70, P< 0.01 and r = -0.75,P< 0.001 respectively).Thus the assessment of the lipid profile, along with other cardiovascular risk factors should be actively determined and appropriate treatment along with sufficient antioxidants supplementation should form part of the standard treatment protocol in rheumatoid arthritis patients. Source

Bhat M.A.,Indira Gandhi Medical College and Research Institute | Sageerabanoo S.,Aarupadai Veedu Medical College | Kowsalya R.,Institute of Nephrourology | Sarkar G.,Subharathi Medical College
Journal of Clinical and Diagnostic Research | Year: 2012

Introduction: The Extended Spectrum Beta Lactamases (ESBLs) are the class A plasmid mediated enzymes that hydrolyze the oxyimino-cephalosporins and the monobactams but not the cephamycins and they are inhibited by clavulanic acid. In the recent years, the CTX-M type are the most common ESBLs which have been isolated. The present study was undertaken to know the prevalence of the ESBL producing E. coli in urinary tract infections (UTIs) and also to know the occurrence of the CTX-M3 genotype among these E. coli which were isolated in our hospital. Materials and Methods: The routine antimicrobial susceptibility testing was done for the E. coli which were isolated from the urine samples. The strains of E. coli that were resistant to cefotaxime and ceftriaxone were selected for the ESBL testing. The strains were tested for ESBL production by the Double Disc Synergy Test (DDST) and the phenotypic confirmatory double disc test (PCDDT) as per the CLSI guidelines. Fifty four isolates of E. coli were found to be positive for ESBL by the phenotypic methods, out of which fifty isolates were tested for the presence of CTX-M3 by PCR and also their minimum inhibitory concentrations (MICs) for ceftazidime were determined. Results: Out of a total of 157 E. coli isolates, 54 isolates (34.4%) were found to be positive for ESBL by the phenotypic methods, DDST and PCDDT. Nearly 21(38.8%) ESBL positive E. coli isolates had an MIC of ≥ 128μg/ml for ceftazidime. Out of the 50 strains of ESBL positive E. coli that were run for PCR, 42(84%) were positive for the CTX-M3 gene. Conclusion: Our study showed that the ESBL producing urinary isolates of E. coli were not only resistant to the third generation cephalosporins but also to ciprofloxacin, cotrimoxazole and gentamicin. The occurrence of the CTX-M3 genotype was high among the E. coli isolates in our study. Source

Samaga M.P.,Mandya Institute of Medical science | Mythri K.M.,Institute of Nephrourology
Journal of Pure and Applied Microbiology | Year: 2012

A prospective study was carried out on patients with diabetic foot ulcers to determine their bacteriological spectrum and to assess their in vitro susceptibility to the commonly used antibiotics. The criterion for inclusion was a diabetic patient with foot ulcer of grade 1 or more according to Meggit Wagner Classification System. Polymicrobial growth was seen where 236 bacteria were isolated with an average of 2.36 per case. Of these isolates, 218 (92.37%) were aerobes and 18(7.63%) were anaerobes. Staphylococcus aureus(22.01%) was the predominant aerobe isolated followed by Proteus mirabilis(19.7%). 16.7% of Staphylococcus aureus were methicillin resistant. All gram positive aerobes showed 100% sensitivity to vancomycin. All gram negative aerobes except Klebsiella spp. and Pseudomonas aeruginosa showed 100% sensitivity to amikacin. The major anaerobes isolated were Bacteroides spp(61.1%) followed by Peptostreptococcus spp(27.8%) and Clostridium spp.(11.1%). Source

A 16-year-old boy underwent visual internal uretherotomy in the lithotomy position for short urethral stricture. The next day, the patient developed right foot drop and sensory loss over the right foot. Published literature describes a long surgery duration in the lithotomy position as the most significant risk factor. In our case, foot drop developed despite short surgical duration in the lithotomy position, signifying the importance of other, less-discussed factors. © 2012 Digital Science Press, Inc. Source

Mahadevappa N.,Institute of Nephrourology | Gudage S.,Victoria Hospital | Senguttavan K.V.,Institute of Nephrourology | Mallya A.,Institute of Nephrourology | Dharwadkar S.,Institute of Nephrourology
Urology Annals | Year: 2016

Objective: Vesicovaginal fistula (VVF) is a major complication with psychosocial ramifications. In literature, few VVF cases have been managed by laparoendoscopic single site surgery (LESS) and for the 1st time we report VVF repair by LESS using conventional laparoscopic instruments. We present our initial experience and to assess its feasibility, safety and outcome. Patients and Methods: From March 2012 to September 2015, LESS VVF repair was done for ten patients aged between 30 and 65 (45.6 ± 10.15) years, who presented with supratrigonal VVF. LESS was performed by modified O'Conor technique using regular trocars with conventional instruments. Data were collected regarding feasibility, intra- or post-operative pain, analgesic requirement, complication, and recovery. Results: All 10 cases were completed successfully, without conversion to a standard laparoscopic or open approach. The mean operative time was 182.5 ± 32.25 (150-250) min. The mean blood loss was 100 mL. The respective mean visual analog score for pain on day 1, 2, and 3 was 9.2 ± 1, 5 ± 1, and 1.4 ± 2.3. The analgesic requirement in the form of intravenous tramadol on days 1, 2, and 3 was 160 ± 51.6, 80 ± 63.2, and 30 ± 48.3, mgs respectively. No major intra- or post-operative complications were observed. The mean hospital stay was 2.6 ± 0.7 (2-4) days. Conclusion: In select patients, LESS extravesical repair of VVF using conventional laparoscopic instruments is safe, feasible with all the advantages of single port surgery at no added cost. Additional experience and comparative studies with conventional laparoscopy are warranted. © 2016 Urology Annals | Published by Wolters Kluwer - Medknow. Source

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