Institute of Natural Products Chemistry

Hanoi, Vietnam

Institute of Natural Products Chemistry

Hanoi, Vietnam
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Tung M.H.T.,Institute of Natural Products Chemistry | Duc H.V.,Institute of Natural Products Chemistry | Huong T.T.,Institute of Natural Products Chemistry | Duong N.T.,Institute of Natural Products Chemistry | And 6 more authors.
Scientia Pharmaceutica | Year: 2013

Ten compounds, including soulameanone (1), isobruceine B (2), 9-methoxy-canthin-6-one (3), bruceolline F (4), niloticine (5), octatriacontan-1-ol (6), bombiprenone (7), α-tocopherol (8), inosine (9), and apigenin 7-O-β-D-glucopyranoside (10), were isolated from the leaves, stems, and roots of Brucea mollis Wall. ex Kurz. Their structures were determined using one- and two-dimensional NMR spectroscopy and mass spectrometry. All compounds were evaluated for their cytotoxic activity against KB (human carcinoma of the mouth), LU-1 (human lung adenocarcinoma), LNCaP (human prostate adeno-carcinoma), and HL-60 (human promyelocytic leukemia) cancer cell lines. Compound 2 showed significant cytotoxic activity against KB, LU-1, LNCaP, and HL-60 cancer cells with IC50 values of 0.39, 0.40, 0.34, and 0.23 μg/mL, respectively. In addition, compounds 3 and 5 showed significant cytotoxic activity against KB, LU-1, LNCaP, and HL-60 cancer cells with IC50 values around 1-4 μg/mL. Compounds 9-methoxycanthin-6-one (3) and niloticine (5) have been discovered for the first time from the Brucea genus. © Tung et al.


Nhiem N.X.,Chungnam National University | Nhiem N.X.,Institute of Natural Products Chemistry | Kiem P.V.,Institute of Natural Products Chemistry | Minh C.V.,Institute of Natural Products Chemistry | And 7 more authors.
Planta Medica | Year: 2010

Three new lupane triterpene glycosides, acankoreosides JL (13), were isolated from the leaves of Acanthopanax koreanum. Based on the spectroscopic data, the chemical structures were determined as 3α-hydroxy-20-oxo-30- norlupane-23,28-dioic 28-Oα-L-rhamnopyranosyl-(1→4)β-D- glucopyranosyl-(1→6)β-D-glucopyranosyl ester (1); 3α,20,29- trihydroxylupane-23,28-dioic 28-Oα-L-rhamnopyranosyl-(1→4)β-D- glucopyranosyl-(1→6)β-D-glucopyranosyl ester (2); and (20S)-3α-hydroxy-29,29-dimethoxylupane-23,28-dioic 28-Oα-L- rhamnopyranosyl-(1→4)β-D-glucopyranosyl-(1→6)β-D- glucopyranosyl ester (3). Compounds 13 were evaluated for their cytotoxicity and showed moderate activity against four cell lines, A549 (lung), HL-60 (leukemia), MCF-7 (breast), and U937 (leukemia), with IC50 values of 23.4, 36.5, 22.6, and 18.5μM for 1; 6.8, 18.6, 23.1, and >100μM for 2; and 28.9, 21.8, 11.0, and 27.5μM for 3, respectively. © Georg Thieme Verlag KG Stuttgart New York.


Minh C.V.,Vietnam Academy of Science and Technology | Kiem P.V.,Vietnam Academy of Science and Technology | Nhiem N.X.,Vietnam Academy of Science and Technology | Cuong N.X.,Vietnam Academy of Science and Technology | And 8 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2011

Two new diterpenes, lobocompactols A (1) and B (2), and five known compounds (3-7) were isolated from the methanol extract of the soft coral Lobophytum compactum using combined chromatographic methods and identified based on NMR and MS data. Each compound was evaluated for cytotoxic activity against A549 (lung) and HL-60 (acute promyelocytic leukemia) human cancer cell lines. Among them, compound 5 exhibited strong cytotoxic activity against the A549 cell line with an IC50 of 4.97 ± 0.06 μM. Compounds 3, 4, and 7 showed moderate activity with IC50 values of 23.03 ± 0.76, 31.13 ± 0.08, and 36.45 ± 0.01 μM, respectively. The cytotoxicity of 5 on the A549 cells was comparable to that of the positive control, mitoxantrone (MX). All compounds exhibited moderate cytotoxicity against the HL-60 cell line, with IC50 values ranging from 17.80 ± 1.43 to 59.06 ± 2.31 μM. Their antioxidant activity was also measured using oxygen radical absorbance capacity method, compounds 1 and 2 exhibiting moderate peroxyl radical scavenging activity of 1.4 and 1.3 μM Trolox equivalents, respectively, at a concentration of 5 μM. © 2011 Elsevier Ltd. All rights reserved.


Quang T.H.,Chungnam National University | Quang T.H.,Vietnam Academy of Science and Technology | Ha T.T.,Vietnam Academy of Science and Technology | Minh C.V.,Vietnam Academy of Science and Technology | And 13 more authors.
Bioorganic and Medicinal Chemistry | Year: 2011

Four new cembranoids, namely laevigatol A-D (1-4), and six known metabolites (5-10), were isolated from the Vietnamese soft coral Lobophytum laevigatum. The structures of these compounds were elucidated by extensive spectroscopic analyses, and the absolute stereochemistry of 1 was determined using the modified Mosher's method. Compounds 5, and 7-10 exhibited cytotoxic activity against selected human cancer cell lines. Compounds 1, 2, 8, and 9 showed dose-dependent inhibitory effects on the TNFα-induced NF-κB transcriptional activity in Hep-G2 cells. Moreover, compounds 1, 2, 8, and 9 significantly inhibited the induction of COX-2 and iNOS mRNA dose-dependently, indicating that these compounds attenuated the synthesis of these transcripts at the transcriptional level. © 2011 Elsevier Ltd. All rights reserved.


Ikonnikov V.K.,Russian Scientific Center Applied Chemistry | Egoyants P.A.,Russian Scientific Center Applied Chemistry | Sirotin S.A.,Russian Scientific Center Applied Chemistry | Hieu T.T.,Institute of Natural Products Chemistry
Russian Journal of Physical Chemistry B | Year: 2010

The extraction of biologically active substances by carbon dioxide from various plant raw materials (amaranth seeds, Sophora japonica flower buds, Stephania rotunda stems, and Stevia rebaudiana leaves) was studied at sub- and supercritical parameters. A laboratory unit for the extraction of plant raw materials by liquefied gases and supercritical fluids at 5-35 MPa pressures and 285-350 K temperatures was developed. The maximum yield of the extracted substances from plants specified was obtained at temperature and pressure exceeding the critical parameters of CO2 (320-330 K, 28-30 MPa).


Tam N.M.,Vietnam Academy of Science and Technology | Duy V.D.,Vietnam Academy of Science and Technology | Duc N.M.,Institute of Ecology and Biological Resources | Giap V.D.,Institute of Natural Products Chemistry
Research Journal of Biotechnology | Year: 2014

Dipterocarpus costatus (Dipterocarpaceae) is restrictedly distributed in lowland forests in southern Vietnam. Due to over-exploitation and habitat destruction, the species is now threatened. The genetic variation within and among populations of D. costatus was investigated on the basis of nine microsatellite (single sequence repeat, SSR) loci. In all, 266 sampled trees from nine populations in southern Vietnam were analyzed in this study. The SSR data showed a low genetic variability within populations with an average of Ho = 0.085 and He = 0.109. Genetic differentiation among populations was high (Gst = 0.375), indicating limited gene flow (Nm = 0.83). Analysis of molecular variance analysis showed that most genetic variation was within populations (63.22%). This study highlights the importance of conserving the genetic resources of D. costatus species.


Tai B.H.,Chungnam National University | Tai B.H.,Institute of Natural Products Chemistry | Nhiem N.X.,Chungnam National University | Nhiem N.X.,Institute of Marine Biochemistry | And 8 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2011

A new iridoid, named methylscutelloside (1) together with 19 known compounds belonging to the iridoids (2-4), monoterpenoids (5), flavonoids (6-8), triterpenoids (9-14), and phenylethanoids (15-20) were isolated from the flowers of Buddleja officinalis. Their chemical structures were elucidated on the basis of physicochemical properties, and by spectroscopic methods including 1D, 2D NMR, and MS. All isolated compounds were tested in vitro for their effects on the proliferation of rat aortic vascular smooth muscle cells (VSMCs). Among them, iridoids were the main active components and showed significant inhibitory effects on PDGF-BB-induced proliferation in rat aortic VSMCs. © 2011 Elsevier Ltd. All rights reserved. © 2011 Elsevier Ltd. All rights reserved.


Huong L.M.,Institute of Natural Products Chemistry | Thu H.P.,Institute of Materials Science | Thuy N.T.B.,Institute of Natural Products Chemistry | Ha T.T.H.,Institute of Natural Products Chemistry | And 6 more authors.
Chemistry Letters | Year: 2011

The clinical application of curcumin in cancer treatment is considerably limited due to its serious poor delivery characteristics. In order to increase the hydrophilicity and drug delivery capability, we encapsulated curcumin into 1,3-β-glucan isolated from Vietnam medicinal mushroom Hericium erinaceum. The 1,3-β-glucan-encapsulated curcumin nanoparticles (CurGlu) were found to be spherical with an average size of 50 nm, being suitable for drug delivery applications. They were much more soluble in water not only than free curcumin but also than other biodegradable polymer-encapsulated curcumin nanoparticles. An antitumor-promoting assay was carried out, showing the positive effects of CurGlu on tumor promotion of Hep-G2 cell line in vitro. © 2011 The Chemical Society of Japan.


Quang B.T.,IFI | Quang N.H.,IFI | Medernach E.,Laboratoire Of Physique Corpusculaire | Breton V.,Laboratoire Of Physique Corpusculaire | Long P.Q.,Institute of Natural Products Chemistry
ACM International Conference Proceeding Series | Year: 2013

Virtual screening has proven very effective on grid infrastructures where large scale deployments have led to the identification of active inhibitors for biological targets of interest against malaria, SARS or diabetes. Operating a dedicated virtual screening platform on grid resources requires optimizing the scheduling policy. The scheduling can be done at 2 levels; at site level and at platform level. Site scheduling is done at each site independently; each site is autonomous in its choice of job scheduling. Each site allocates time slots for different groups of users. Platform scheduling is done at group level: inside a time slot jobs from many users are allocated. Pilot agents are sent to sites and act as a container of actual users jobs. They pick up users jobs from a central queue where the second stage scheduling is done. In this paper, we focus on pilot-agent platform shared by many virtual screening users. They need a suitable scheduling algorithm to ensure a certain fairness between users. We have studied the scheduling of users jobs inside central queue and examined the relevance and impact of different scheduling policies (FIFO, SPT, LPT and Round Robin) on the user experience. Optimal criterion used in our research is the stretch, a measure for user experience on the platform. In a first step, we simulated the operation of virtual screening applications on the pilot-agent platform in order to compare the scheduling policies. According to simulation, SPT algorithm was shown to significantly improve scheduling performances. In a second step, the Shortest Processing Time (SPT) and Longest Processing Time (LPT) scheduling policies were implemented on a DIRAC pilot-agent platform at IFI in Hanoi and tested on EGI Biomed Virtual Organization. Experimental results are in good agreement with simulation and confirm that SPT algorithm significantly improves user experience. The relevance of our conclusions also extends to cloud computing. Indeed, cloud infrastructures are also characterized by limited machine availability. Copyright © 2013 ACM.


PubMed | Institute of Natural Products Chemistry
Type: Journal Article | Journal: Scientia pharmaceutica | Year: 2013

Ten compounds, including soulameanone (1), isobruceine B (2), 9-methoxy-canthin-6-one (3), bruceolline F (4), niloticine (5), octatriacontan-1-ol (6), bombiprenone (7), -tocopherol (8), inosine (9), and apigenin 7-O--D-glucopyranoside (10), were isolated from the leaves, stems, and roots of Brucea mollis Wall. ex Kurz. Their structures were determined using one-and two-dimensional NMR spectroscopy and mass spectrometry. All compounds were evaluated for their cytotoxic activity against KB (human carcinoma of the mouth), LU-1 (human lung adenocarcinoma), LNCaP (human prostate adeno-carcinoma), and HL-60 (human promyelocytic leukemia) cancer cell lines. Compound 2 showed significant cytotoxic activity against KB, LU-1, LNCaP, and HL-60 cancer cells with IC50 values of 0.39, 0.40, 0.34, and 0.23 g/mL, respectively. In addition, compounds 3 and 5 showed significant cytotoxic activity against KB, LU-1, LNCaP, and HL-60 cancer cells with IC50 values around 1-4 g/mL. Compounds 9-methoxycanthin-6-one (3) and niloticine (5) have been discovered for the first time from the Brucea genus.

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