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Latypov Y.Y.,RAS A.V. Zhirmunsky Institute of Marine Biology | Ly B.M.,Nhatrang Institute of Technology Research and Application | Hoang L.H.,Khanh Hoa Salanganes Nest Company | Long P.Q.,Institute of Natural Products Chemistry | Khoa N.B.,Nhatrang Institute of Technology Research and Application
Russian Journal of Marine Biology | Year: 2013

In 2010-2011, experimental commercial cultivation of 14 species of hermatypic corals was carried out using the method of donor colony fragmentation. The transplants successfully survived on experimental frame installations. The coral colonies that were recovered from the fragments became attached to the frame installations in a similar way to their attachment on natural substrata. After 1 year, the size of the trans-plants was found to have increased by 275%. The newly formed artificial coral community was colonized by the damselfish Dascyllus reticulates (Pomacentridae); the species is a common coral fish species that lives on natural reefs. © 2013 Pleiades Publishing, Ltd. Source


Tam N.M.,Vietnam Academy of Science and Technology | Duy V.D.,Vietnam Academy of Science and Technology | Duc N.M.,Institute of Ecology and Biological Resources | Giap V.D.,Institute of Natural Products Chemistry
Research Journal of Biotechnology | Year: 2014

Dipterocarpus costatus (Dipterocarpaceae) is restrictedly distributed in lowland forests in southern Vietnam. Due to over-exploitation and habitat destruction, the species is now threatened. The genetic variation within and among populations of D. costatus was investigated on the basis of nine microsatellite (single sequence repeat, SSR) loci. In all, 266 sampled trees from nine populations in southern Vietnam were analyzed in this study. The SSR data showed a low genetic variability within populations with an average of Ho = 0.085 and He = 0.109. Genetic differentiation among populations was high (Gst = 0.375), indicating limited gene flow (Nm = 0.83). Analysis of molecular variance analysis showed that most genetic variation was within populations (63.22%). This study highlights the importance of conserving the genetic resources of D. costatus species. Source


Quang T.H.,Chungnam National University | Quang T.H.,Vietnam Academy of Science and Technology | Ha T.T.,Vietnam Academy of Science and Technology | Minh C.V.,Vietnam Academy of Science and Technology | And 13 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2011

A new unusual sterol, named lobophytosterol (1), and five known metabolites (2-6) were isolated from the methanol extract of the soft coral Lobophytum laevigatum. Their chemical structures were elucidated by extensive spectroscopic analysis and comparison with those reported in the literature. The absolute stereochemistry of 1 was determined using a modified Mosher's method. Compounds 1-3 showed cytotoxic activity against HCT-116 cells with IC50 values of 3.2, 6.9 and 18.1 μM, respectively. Compound 1 additionally displayed cytotoxic effects on A549 and HL-60 cells with IC50 values of 4.5 and 5.6 μM, respectively. Treatment of these cells with compound 1 resulted in an induction of apoptosis evident by chromatin condensation in treated cells. Besides, compounds 2, 4, and 6 significantly upregulated PPARs transcriptional activity dose-dependently in Hep-G2 cells. Taken together, these data suggest that compound 1 might inhibit the growth of the cancer cells by the induction of apoptosis, and compounds 2, 4, and 6 might act as specific agonists for PPARα, PPARδ, and PPARγ and may therefore regulate cellular glucose, lipid, and cholesterol metabolism. © 2011 Elsevier Ltd. All rights reserved. Source


Ikonnikov V.K.,Russian Scientific Center Applied Chemistry | Egoyants P.A.,Russian Scientific Center Applied Chemistry | Sirotin S.A.,Russian Scientific Center Applied Chemistry | Hieu T.T.,Institute of Natural Products Chemistry
Russian Journal of Physical Chemistry B | Year: 2010

The extraction of biologically active substances by carbon dioxide from various plant raw materials (amaranth seeds, Sophora japonica flower buds, Stephania rotunda stems, and Stevia rebaudiana leaves) was studied at sub- and supercritical parameters. A laboratory unit for the extraction of plant raw materials by liquefied gases and supercritical fluids at 5-35 MPa pressures and 285-350 K temperatures was developed. The maximum yield of the extracted substances from plants specified was obtained at temperature and pressure exceeding the critical parameters of CO2 (320-330 K, 28-30 MPa). Source


Minh C.V.,Vietnam Academy of Science and Technology | Kiem P.V.,Vietnam Academy of Science and Technology | Nhiem N.X.,Vietnam Academy of Science and Technology | Cuong N.X.,Vietnam Academy of Science and Technology | And 8 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2011

Two new diterpenes, lobocompactols A (1) and B (2), and five known compounds (3-7) were isolated from the methanol extract of the soft coral Lobophytum compactum using combined chromatographic methods and identified based on NMR and MS data. Each compound was evaluated for cytotoxic activity against A549 (lung) and HL-60 (acute promyelocytic leukemia) human cancer cell lines. Among them, compound 5 exhibited strong cytotoxic activity against the A549 cell line with an IC50 of 4.97 ± 0.06 μM. Compounds 3, 4, and 7 showed moderate activity with IC50 values of 23.03 ± 0.76, 31.13 ± 0.08, and 36.45 ± 0.01 μM, respectively. The cytotoxicity of 5 on the A549 cells was comparable to that of the positive control, mitoxantrone (MX). All compounds exhibited moderate cytotoxicity against the HL-60 cell line, with IC50 values ranging from 17.80 ± 1.43 to 59.06 ± 2.31 μM. Their antioxidant activity was also measured using oxygen radical absorbance capacity method, compounds 1 and 2 exhibiting moderate peroxyl radical scavenging activity of 1.4 and 1.3 μM Trolox equivalents, respectively, at a concentration of 5 μM. © 2011 Elsevier Ltd. All rights reserved. Source

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