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Hsu H.-L.,National Taiwan University | Teng L.-J.,National Chiao Tung University | Chen Y.-C.,Institute of Electronics Engineering | Hsu W.-L.,NTHU | And 6 more authors.
Advanced Materials | Year: 2010

Carbon nanotubes were grown on flexible polylmide substrates at temperatures below 400°C as electrodes for extracellularly neuronal recording. The electrical charge-transfer and electrochemical properties of such CNT electrodes were enhanced by UV-ozone exposure, which induced the formation of C-O, C=O, and O-C=O bonds and reduced the CNT/ electrolyte Interfacial Impedance while increasing the interfacial capacitance. Figure presented © 2010 WILEY-VCH Verlag GmbH & Co. KGaA. Source


Punde T.H.,Institute of NanoEngineering and MicroSystems | Wu W.-H.,Taiwan Power | Lien P.-C.,National Tsing Hua University | Shih P.-C.,Taiwan Power | And 4 more authors.
Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 | Year: 2012

We report a 3D biomimetic microsystem which mimics lung microenvironment for monitoring the role of chemokine induced lung inflammation. The extravasation of fibrocytes in response to eosinophil cationic protein (ECP)-stimulated bronchial epithelial cells induced lung inflammation was mimicked on the micro-fluidic chip system for monitoring the microenvironmental changes. Source


Li M.-H.,National Tsing Hua University | Chen C.-Y.,National Tsing Hua University | Liu C.-Y.,National Tsing Hua University | Li S.-S.,National Tsing Hua University | Li S.-S.,Institute of NanoEngineering and MicroSystems
IEEE Electron Device Letters | Year: 2016

This letter presents the design of a low power, low phase noise monolithic oscillator with a back-end-of-line-embedded CMOS-MEMS resonator. The proposed CMOS-MEMS oscillator consists of a double-ended tuning fork resonator and a high gain (>138 dBΩ) ultra-low input-referred current noise (<25 fA/√Hz) integrator-differentiator transimpedance amplifier (TIA) with sub-150-μW power consumption. The 1.2-MHz CMOS-MEMS oscillator prototype shows the phase noise better than -120 dBc/Hz at 1-kHz offset and -122 dBc/Hz at 10-kHz offset with moderate dc-bias (VP = 22 V). The proposed oscillator can be operated with reduced MEMS dc bias (VP < 7 V) and TIA power supply (VDD < 1.3 V, 65 μW) while maintaining satisfactory performance. The frequency-power-normalized oscillator phase noise figure-of-merit (will be defined later) of 190 dB is achieved at 1-kHz offset with a resonator Q of 1900, which is comparable with the state-of-the-art using bulk-mode resonators possessing Q > 100 k. © 1980-2012 IEEE. Source


Shen H.-H.,Institute of NanoEngineering and MicroSystems | Su T.-Y.,Institute of NanoEngineering and MicroSystems | Chang H.-Y.,Institute of Molecular Medicine | Yao D.-J.,Institute of NanoEngineering and MicroSystems
2012 IEEE Nanotechnology Materials and Devices Conference, IEEE NMDC 2012 | Year: 2012

This study based on the technique, "Electrowetting on Dielectric (EWOD)," with the micro-heaters designed in EWOD microfluidics system for temperature controlling in biomedical reaction. On this platform, fluorescence magnetic beads (MBs) were used as carriers for single-nucleotide polymorphism (SNP) detection. In human genome, SNPs are responsible for the variations between individuals. The genome of a person comprise specific SNP could result in responsiveness to drug therapies and sensitivity of certain disease. Therefore, SNP is considered as one of the keys to predict the affect in pharmacogenomic medicine. In this study, SNP detection has been demonstrated on this thermal controllable EWOD platform in order to approach the goal of "lab-on-a-chip". © 2012 IEEE. Source


Chang J.-M.,Institute of NanoEngineering and MicroSystems | Chang W.-Y.,National Tsing Hua University | Chen F.-R.,National Tsing Hua University | Tseng F.-G.,Institute of NanoEngineering and MicroSystems | And 2 more authors.
Nanoscale Research Letters | Year: 2013

A single 210-nm Teflon nanoparticle (sTNP) was attached to the vertex of a silicon nitride (Si3N4) atomic force microscope tip and charged via contact electrification. The charged sTNP can then be considered a point charge and used to measure the electrostatic field adjacent to a parallel plate condenser using 30-nm gold/20-nm titanium as electrodes. This technique can provide a measurement resolution of 250/100 nm along the X- and Z-axes, and the minimum electrostatic force can be measured within 50 pN. © 2013 Chang et al.; licensee Springer. Source

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