Institute of Medicinal Plants

Karaj, Iran

Institute of Medicinal Plants

Karaj, Iran
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Arbabi M.,Tehran University of Medical Sciences | Bagheri M.,Tehran University of Medical Sciences | Rezaei F.,Kurdistan University of Medical Sciences | Ahmadi-Abhari S.-A.,Tehran University of Medical Sciences | And 3 more authors.
Psychopharmacology | Year: 2012

Rational In recent years, evidence suggests that modafinil may be useful for certain symptom domains of schizophrenia, especially for the negative and cognitive symptoms. However, the results are not consistent. Objective This study was designed to investigate the effect of modafinil added to risperidone in patients with chronic schizophrenia in a double blind and randomized clinical trial. Methods Participants were inpatients males (35) and females (11), ages 20-49 years at two teaching psychiatric hospital in Iran. All patients were in the active phase of the illness and met DSM-IV-TR criteria for schizophrenia. Patients were allocated in a random fashion 23 patients to risperidone 6 mg/day plus modafinil 200 mg/day and 23 patients to risperidone 6 mg/day plus placebo. The principal measure of outcome was the positive and negative syndrome scale (PANSS). Patients were assessed by a psychiatrist at baseline and after 2, 4, 6 and 8 weeks after the start of medication. Results The modafinil group had significantly greater improvement in the negative symptoms as well as PANSS total scores over the 8-week trial. Therapy with 200 mg/day of modafinil was well tolerated and no clinically important side effects were observed. Conclusion The present study indicates modafinil as a potential adjunctive treatment strategy for treatment of schizophrenia particularly the negative symptoms. Nevertheless, results of larger-controlled trials are needed before recommendation for broad clinical application can be made. This trial is registered with the Iranian Clinical Trials Registry (IRCT138903131556N16). © 2011 Springer-Verlag.

Fallah Huseini H.,Institute of Medicinal Plants | Amini M.,Baqiyatallah Medical Sciences University | Mohtashami R.,Baqiyatallah Medical Sciences University | Ghamarchehre M.E.,Baqiyatallah Medical Sciences University | And 3 more authors.
Phytotherapy Research | Year: 2013

Nigella sativa L. seeds (N. sativa) have been used as a traditional remedy for a wide range of diseases including hypertension. The present study was performed to explore the effects of N. sativa oil on blood pressure (BP) in healthy volunteers. In a double-blind, randomized study, 70 healthy volunteers aged 34 to 63 years with systolic BP from 110 to 140 mmHg and diastolic BP from 60 to 90 mmHg were randomly allocated to receive 2.5 mL N. sativa oil or placebo two times a day for 8 weeks. The systolic and diastolic BPs, body mass index and blood levels of aspartate transaminase, alanine transaminase, alkaline phosphatase, creatinine and blood urea nitrogen were determined at baseline and endpoint. Results showed that in N. sativa oil treated group the systolic and diastolic BPs decreased significantly compared with baseline and placebo group at the endpoint. Other parameters did not significantly change in both groups at the endpoint. No adverse effects were reported. In conclusion, oral daily administration of 5 mL N. sativa oil to healthy volunteers for 8 weeks lowers systolic and diastolic BPs without any adverse effects. Copyright © 2013 John Wiley & Sons, Ltd. Copyright © 2013 John Wiley & Sons, Ltd.

Amiri S.,Tehran University of Medical Sciences | Haj-Mirzaian A.,Tehran University of Medical Sciences | Rahimi-balaei M.,University of Manitoba | Razmi A.,Institute of Medicinal Plants | And 5 more authors.
Physiology and Behavior | Year: 2015

Approximately more than 50% of patients with depression have the co-occurrence of anxiety, which complicates the treatment of disease. Recently, social isolation stress (SIS) paradigm has been suggested as an animal model to investigate the underlying mechanism involved in depression-anxiety co-occurrence. In this study, applying six weeks of SIS to adolescent mice, we tested whether nitrergic system plays a role in co-occurrence of depression and anxiety. In this study, comparisons between socially and isolated conditioned (SC and IC) animals showed that SIS induces behaviors relevant to depression and anxiety in IC mice and in addition, nitrergic system is involved in mediating the negative outcomes of SIS. Administration of subeffective doses of aminoguanidine (a specific inducible nitric oxide synthase inhibitor or iNOS, 50. mg/kg) and L-NAME (non-specific inhibitor of NOS, 10. mg/kg) significantly reversed the negative effects of SIS on behavioral profile as well as nitrite levels in the cortex of IC mice, Although administration of subeffective dose of 7-nitroindazole (a specific neuronal NOS inhibitor, 25. mg/kg) decreased the nitrite levels in the hippocampus, but had no effect on depressant and anxiogenic effects of SIS. Results of this study confirmed that SIS is an appropriate animal model to investigate the potential mechanisms in depression-anxiety co-occurrence. We also showed that nitrergic system has contributed to co-occurrence of depression and anxiety in IC mice as an underlying mechanism. © 2015 .

Mozaffari S.,Tehran University of Medical Sciences | Nikfar S.,Tehran University of Medical Sciences | Nikfar S.,U.S. Food and Drug Administration | Abdolghaffari A.H.,Institute of Medicinal Plants | And 2 more authors.
Expert Opinion on Biological Therapy | Year: 2014

Introduction: Some inflammatory bowel disease (IBD) patients especially those with refractory Crohn's disease (CD) or relapsing ulcerative colitis (UC) do not respond to current therapies. The newly introduced biological drugs have got some interest due to their specificity and selectivity in modulation of inflammatory elements. Areas covered: In 46 included randomized, placebo-controlled clinical trials, the efficacy and safety of different biologic drugs have been evaluated in moderately to severely active CD or UC patients. Current investigated drugs include new anti-TNF drugs (adalimumab, certolizumab pegol, etanercept, onercept and golimumab), anti-CD20 (rituximab), T-cell inhibitors (abatacept) and anti-α4 integrins (natalizumab and vedolizumab). Adalimumab, certolizumab, and golimumab showed significant efficacy in induction of remission and maintenance in CD and UC patients with a rate of adverse events similar to placebo in the major trials. Natalizumab and vedolizumab were effective in the treatment of moderately to severely active CD and UC patients. However, vedolizumab caused less adverse effects than natalizumab. onercept, etanercept, rituximab and abatacept were all well tolerated but were not effective in CD or UC patients. Expert opinion: Anti-TNF drugs, except for onercept and etanercept, and anti-α4 integrins exhibit beneficial therapeutic effects. Although they were all well tolerated, the incidence of progressive multifocal leukoencephalopathy associated with natalizumab should not be missed. © 2014 Informa UK, Ltd.

Khanahmadi M.,Kermanshah Branch of ACECR | Rezazadeh S.H.,Institute of Medicinal Plants | Tara M.,Razi University
Asian Journal of Plant Sciences | Year: 2010

The aim of this study was to investigate antioxidant and antibacterial activities of ethanolic extract of Smyrnium cordifolium Boiss. the ethanolic extract was subjected to screening for its possible antioxidant activity. Namely DPPH free radical scavenging, FTC system and total phenolic compounds were used. Also, Antibacterial activity of ethanolic extract using Gentamicin and Tetracycline as the reference standards were tested against Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Klebsiella pneumoniae. The results revealed good antioxidant activity of the extract. The ethanolic extract of S. cordifolium exhibited an antibacterial activity at different levels against strains reported as the causal agents of diseases and this extract inhibited Gram positive bacteria significantly higher than Gram negative bacteria. Observed antioxidant and antibacterial properties of ethanolic extract of the S. cordifolium in this study showed that this plant might be useful source for the development of new and more potent natural antioxidants and antibacterial. © 2010 Asian Network for Scientific Information.

Saei-Dehkordi S.S.,Shahrekord University | Tajik H.,Urmia University | Moradi M.,Urmia University | Khalighi-Sigaroodi F.,Institute of Medicinal Plants
Food and Chemical Toxicology | Year: 2010

The objective of the study was to characterize the chemical constituents, antioxidant and antibacterial properties of five ecotypes of Zataria multiflora Boiss. essential oil with respect to main phytogeographic grown towns in Iran. Our investigation showed that the plants had essential oil yield ranging from 1.59±0.86% to 0.99±0.29% v/w. There were qualitative similarities among the oils from different origins, whereas the amounts of some components were varied. From different samples, 34, 34, 32, 29 and 53 various compounds were identified, representing 98.32%, 97.77%, 99.5%, 98.38% and 96.54% of total oils, respectively. The highest oxygenated monoterpens value in this study stood at 72.99%. Moreover, thymol, a phenolic compound of oxygenated monoterpens, was the most abundant component in GC/MS ranging from 27.05% to 64.87%. In the DPPH antioxidant assay, all samples exhibited a remarkable activity with a higher degree of IC50=19.7±0.7μg/ml almost similar to BHT (18.1±0.4μg/ml). Escherichia coli O157:H7 was the most resistant and Candida tropicalis was the most vulnerable organisms with MICs of 16 and 0.062mg/ml, respectively. In conclusion, it seemed that geographical variation might have influenced the oil compounds either quantitatively or qualitatively. © 2010 Elsevier Ltd.

Abdoli M.,Tarbiat Modares University | Moieni A.,Tarbiat Modares University | Naghdi Badi H.,Institute of Medicinal Plants
Acta Physiologiae Plantarum | Year: 2013

Echinacea purpurea (L.) is one of the important medicinal plant species. To obtain the tetraploid plants of Echinacea purpurea with improved medicinal qualities, the root tips of two true leaves seedlings were imbibed in 0.25 % (w/v) colchicine solution for 24, 48, 72, 96 and 168 h. The ploidy level of plants was determined by chromosome counting of root tip cells, and confirmed by flow cytometric analysis. Tetraploid induction occurred in seedlings treated for 24, 48 and 72 h at colchicine solution. The morphological, physiological, cytological, and phytochemical characteristics of diploid and colchicine-induced tetraploid plants were compared. Results indicated that tetraploid plants had considerable larger stomata, pollen grain, seed and flower. Moreover, chloroplast number in guard cells, amount of chlorophyll (a, b, and a + b), carotenoids as well as width and thickness of leaves were increased in tetraploids. However, stomata frequency, leaf index, plant height, and quantum efficiency of photosystem II in tetraploid were lower than diploid plants. High-performance liquid chromatography analysis showed that leaves of the tetraploid plants had more cichoric acid (45 %) and chlorogenic acid (71 %) than diploid plants. It was concluded that morphological and physiological characteristics can be used as useful parameters for preliminary screening of putative tetraploids in this species. © 2013 Franciszek Górski Institute of Plant Physiology, Polish Academy of Sciences, Kraków.

Kianbakht S.,Institute of Medicinal Plants | Hajiaghaee R.,Institute of Medicinal Plants
Journal of Medicinal Plants | Year: 2011

Background: Saffron is the dried stigmata of the flowers of saffron (Crocus sativus L., Iridaceae). Saffron and its major active constituents, crocin (crocetin glycoside), crocetin and safranal, have a variety of pharmacological effects including high antioxidant properties and crocetin has insulin sensitizing effect possibly due to its antioxidant activity. Oral crocin is not absorbed and is hydrolyzed and absorbed as the active metabolite crocetin in the rat intestines. Objective: Study of the saffron, crocin and safranal effects on the blood levels of fasting glucose, HbA1c (glycosylated hemoglobin) and liver/kidney function tests in alloxan-diabetic rats. Methods: The effects of 6 weeks' daily oral administration of saffron methanolic extract, crocin and safranal on the fasting blood glucose, HbA1c, insulin, creatinine and SGOT and SGPT levels after single alloxan intraperitoneal injection at a dose of 125 mg/kg in rats were evaluated. Results: Alloxan injection resulted in significant increase of fasting blood glucose and HbA1c levels but decreased blood insulin levels significantly. Saffron methanolic extract (80 and 240 mg/kg), crocin (50 and 150 mg/kg) and safranal (0.25 and 0.5 ml/kg) significantly reduced the fasting blood glucose and HbA1c levels but significantly increased the blood insulin levels without any significant effects on the blood SGOT, SGPT and creatinine levels in the diabetic rats compared with the control diabetic rats. Conclusion: The results suggest that saffron may have anti-hyperglycemic and blood insulin level elevating effects without hepatic and renal toxicities in the alloxan - diabetic rats. Further, crocin, crocetin and safranal may be involved in these effects of saffron.

Azadmehr A.,Qazvin University of Medical Sciences | Hajiaghaee R.,Institute of Medicinal Plants | Mazandarani M.,Qazvin University of Medical Sciences
Cell Proliferation | Year: 2013

Objectives: Scrophularia striata Boiss (Scrophulariaceae) is a plant that grows in northeastern Iran; it has been used traditionally to treat various inflammatory disorders. This study was designed to investigate cytotoxic effects of S. striata extract, on the Jurkat human leukaemia cell line (T-cell leukaemia). Materials and methods: Phytochemical assay by thin layer chromatography and 2, 2 diphenyl-1-picryl-hydrazyl were used to evaluate main compounds and antioxidant capacity of the plant extract, respectively. Its inhibitory effect on Jurkat cells was evaluated by MTT assay. In addition, cell cycle distribution and apoptotic cell death were evaluated by propidium iodide and annexin V-FITC/ propidium iodide staining. Results: These showed that the main components present in S. striata extract included flavonoids, phenolic compounds and phenyl propanoids. Treatment with extract was significantly cytotoxic to the tumour cell line. In addition, flow cytometry analysis indicated that S. striata extract induced cell cycle arrest in G2/M phase and apoptosis of tumour cells. Conclusions: Results of the study indicated that S. striata extract could inhibit leukaemia cell proliferation by inducing G2/M phase arrest and apoptosis. © 2013 John Wiley & Sons Ltd.

Dolatkhahi M.,Payame Noor University | Ghorbani Nohooji M.,Institute of Medicinal Plants
Journal of Medicinal Plants | Year: 2013

Background: Dashtestan, with 6371 km2 area, is situated at 85 km in the east of Bushehr city. Influence of some important ecological factores, such as neighboring to the Persian Gulf, passing two rivers of dalaki and shapoor and also presence of southern continuation of Zagros Mountains are leading to high importance of region in plant biodiversity view point. Objective: Study on the medicinal plant flora of the region and introducing some information of folk medicine and the most useful medicinal species were objected here. Methods: All ancient regions of the Dashtestan were discovered using appropriate geographical maps and then the plant species were gathered from various localities respectively. Vernacular information of collected plants and their usages in the folk medicine were questioned from well experienced people. In final stage the collected plants were identified scientifically after deposition in the herbarium. Results: A total of 85 plant species representing 70 genera and 39 families are identified in the area. The most abundant families of the region are Asteraceae (10 species) and Lamiaceae (8 species) respectively, and the largest genera is Ziziphus (Rhamnaceae) with 6 species. The most folk medicine usage of them is in the remediation of digestive diseases. Conclusion: Traditional usage of medicinal plant is more accepted among the people of area. The most of medicinal herbs are used mainly in remediation of digestive diseases. Considering the culture of society and attention of people to medicinal plants, it may be an attractive object from the farmacological view point.

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