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Novgorodtseva T.P.,Institute of Medical Climatology and Rehabilitation Treatment | Gvozdenko T.A.,Institute of Medical Climatology and Rehabilitation Treatment | Kasyanov S.P.,Pacific Research Fisheries Center | Knyshova V.V.,Institute of Medical Climatology and Rehabilitation Treatment | Karaman Yu.K.,Institute of Medical Climatology and Rehabilitation Treatment
Voprosy Pitaniia | Year: 2010

The impact of different doses of food biologically active additive (BAA) on base lipid sea-hydrobions on the condition of water-electrolyte and nitrogen metabolism, proteinosynthesis and hepatobiliary functions of liver has been studied for rats with the experimental cardio-vascularpathology. BAA is the lipid fraction from schoolmaster gonate squid Berryteuthis magister liver, containing 10% of polyunsaturated fatty acids (PUFA) and 50% of alkyldiacylglycerides. In relation to organism's emunctory systems in conditions of experimental cardio-vascular pathology the biotropic dose makes 1 g/kg daily. BAA acts negatively in dose 2 g/kg daily. It is conditioned by aggravation of electrolyte imbalance, lowering of excretion and reabsorption of sodium, potassium, magnesium, metabolites of purine and nitrogen metabolism, stimulation of intoxication and calcification processes, load effect on proteinosynthesis function of rats liver.


Kalinina E.P.,Institute of Medical Climatology and Rehabilitation Treatment | Denisenko Y.K.,Institute of Medical Climatology and Rehabilitation Treatment | Vitkina T.I.,Institute of Medical Climatology and Rehabilitation Treatment | Lobanova E.G.,Institute of Medical Climatology and Rehabilitation Treatment | And 5 more authors.
Canadian Respiratory Journal | Year: 2016

Background. Comorbidity of chronic obstructive pulmonary disease (COPD) and asthma (asthma COPD overlap syndrome, ACOS) is a significant problem in pulmonary practice, whose pathogenetic issues are not clarified yet. Objective. To study the features of the regulation of immune response in patients with comorbid COPD and asthma. Methods. We assessed the levels of CD3+, CD4+, CD8+, CD4+/CD8+, CD19+, CD25+, HLA-DR, total IgE, TNF-α, IL-4, IFN-γ, TXB2, and LTB4 in patients with comorbid COPD and asthma. Results. The study involved 44 people with COPD, 39 people with asthma, and 12 people with comorbid COPD and asthma. The specific features in comorbid COPD and asthma were lymphocytosis, increased absolute count of T-helper cells, increased cytotoxic T-lymphocytes in relative and absolute count, increased relative and absolute numbers of B-lymphocytes, and high levels of total IgE. The elevated levels of TNF-α and IL-4 and inhibition of IFN-γ production were detected. The content of LTB4 was maximal; TXB2 levels were higher than in control group but lower than in COPD and asthma. Conclusion. In comorbid COPD and asthma inflammation increased even during stable period. High levels of eicosanoids, low production of Th1-type cytokines, and active synthesis of opposition IL-4, along with increased IgE, indicate the activation of Th2-type immune response. © 2016 Elena P. Kalinina et al.

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