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Kahumoku E.P.,Auburn University | Vazsonyi A.T.,Auburn University | Pagava K.,Tbilisi State Medical University | Phagava H.,Institute of Medical Biotechnology | And 2 more authors.
Journal of Adolescent Health | Year: 2011

Purpose The current study tested both descriptive and explanatory similarities and differences in a latent objectified body consciousness (OBC) construct and its relationship to three mental health indicators among Georgian and Swiss adolescents. Few studies have been conducted on adolescents; similarly, most work has been completed on U.S. college-age women. Methods School-based questionnaire data were collected from a total of 18,239 adolescents in Georgia (n = 9,499) and Switzerland (n = 8,740), following the same protocol. Participants rated three measures of OBC (body shame, body surveillance, and appearance control beliefs) and three mental health indicators (depressive symptoms, somatic complaints, and suicidal ideation). Final study samples included 2,657 (mean age = 16.4 years) and 3,803 female youth (mean age = 17.8 years), respectively. Data analyses included mean level comparisons, confirmatory factor analysis, path analysis, and multigroup invariance tests. Results Findings provide support for a latent OBC construct across cultures, with partial evidence of cultural differences (one of two manifest indicators). By contrast, multigroup invariance tests provide consistent evidence of no differences in the relationships between the OBC latent construct and three mental health indicators between Georgian and Swiss samples. Conclusion Despite mean level differences, findings support a latent OBC construct in both cultures, perhaps slightly more so among Swiss youth. The links between OBC and mental health indicators were also invariant across the two cultures, providing greater support for a global or universal (vs. "cultured") framework of adolescent development related to the constructs and relationships studied. © 2011 Society for Adolescent Health and Medicine.

Pantsulaia I.,Institute of Medical Biotechnology | Pantsulaia I.,Tbilisi State Medical University | Kalichman L.,Ben - Gurion University of the Negev | Kobyliansky E.,Tel Aviv University
Osteoarthritis and Cartilage | Year: 2010

Objective: The aim of the study was to evaluate the association between prevalence and severity of radiographic hand osteoarthritis (OA) and serum levels of systemic inflammatory markers in a community-based population sample. Design: A cross-sectional observational study was conducted on a population comprised 1452 Chuvashians (763 males, aged 49.23±17.43; and 689 females, aged 50.37±17.47 years). OA was evaluated in 14 joints of each hand using Kellgren and Lawrence (K-L), joint space narrowing (JSN) and osteophyte (OS) scores. Serum levels of systemic inflammatory and osteoclastogenic cytokines were measured by an enzyme-linked immunosorbent assay (ELISA). Statistical analyses included descriptive statistics, correlation analysis and multiple linear regressions. Results: Monocyte chemotactic protein-1 (MCP-1) and osteoprotegerin (OPG) levels were associated with OA traits, but the statistically significant correlations were weak and/or moderate. In particular, the MCP-1 inflammation marker showed a statistically significant association with JSN (β= 0.077, P= 0.022) and OS (β= 0.067, P= 0.024) scores, but not with the number of affected joints (K-L≥2). OPG was significantly correlated with the scores as to the number of affected joints (β= 0.063, P= 0.035) and OS (β= 0.077, P= 0.028). No significant associations were found between levels of other inflammatory [interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-17] and osteoclastogenic [receptor activator for nuclear factor κ B ligand (RANKL), macrophage colony-stimulating factor (M-CSF)] cytokines and OA characteristics. Conclusions: This study strengthens the premise that OPG might be a valid biomarker of hand OA. Confirmation of these results in larger cohorts of patients will reinforce our theory that the RANKL/OPG pathway is a suitable target for developing novel agents against OA. © 2010.

Kalichman L.,Ben - Gurion University of the Negev | Pantsulaia I.,Institute of Medical Biotechnology | Pantsulaia I.,Tbilisi State Medical University | Kobyliansky E.,Research Unit
Clinical and Experimental Rheumatology | Year: 2011

Background. A recent study showed that the level of soluble Vascular Cell Adhesion Molecule 1 (VCAM-1) emerged as a strong and independent predictor of the risk of hip and knee joint replacement due to severe osteoarthritis (OA). Therefore, we hypothesized that soluble VCAM-1 level can be associated with prevalence and severity of radiographic hand OA. Objective. To evaluate the association between soluble VCAM-1, and radiographic hand OA in a large community-based sample. Methods. The study population comprised Chuvashians (473 males age 45.90±17.16; and 451 females, age 46.18±16.70 years). OA was evaluated for 14 joints of each hand using Kellgren and Lawrence (K-L). OA was characterised by the number of affected joints and by the presence of at least one affected joint. The VCAM-1 level was determined by a sandwich enzyme immunoassay technique using ELISA-OSTEO kit. Statistical analyses included multiple linear and logistic regressions. Results. The linear regression model showed a significant association of a number of affected joints with VCAM-1 level (p=0.004) after adjustment for age, sex, BMI. In the logistic regression model the level of association between the presence of at least one affected joint and soluble VCAM-1 level was p=0.070 (OR(95%CI): 1.003 (1.000, 1.007)). Conclusions. In this cross-sectional population-based study, we found that the serum level of soluble VCAM-1 level is positively associated with the number of affected joints of hand OA. © Copyright Clinical and Experimental Rheumatology 2011.

Shoja M.M.,Tabriz University of Medical Sciences | Tubbs R.S.,University of Alabama at Birmingham | Ardalan M.R.,Tabriz University of Medical Sciences | Loukas M.,St. Georges University | And 2 more authors.
International Journal of Cardiology | Year: 2010

Vladimir Petrovich Demikhov, a Soviet physiologist and surgeon, made meticulous attempts at reviving heart and lung transplantation in the last century. Herein, we present an English translation of Demikhov's 1969 paper of Transplantation of the Heart, Lungs and other Organs (published in Eksperimental'naia Khirurgiia i Anesteziologiia), which represented a synopsis of his experiences with experimental transplantation. A brief account of Demikhov's life and contributions to transplant medicine is also given. © 2010 Elsevier Ireland Ltd.

Danilenko E.D.,Institute of Medical Biotechnology | Belkina A.O.,Institute of Medical Biotechnology
Russian Journal of Biopharmaceuticals | Year: 2014

In the review experimental data on various strategies for design and study of bisphosphonate-conjugated drugs of different nature to treat bone diseases such as osteoporosis, osteoarthritis, bone metastases and a number of other pathologies of the skeletal system are considered. © 2014 Folium Ltd. All rights reserved.

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