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Rochelle-Newall E.J.,Montpellier University | Chu V.T.,Institute of Marine Environment and Resources IMER | Pringault O.,Montpellier University | Amouroux D.,University of Pau and Pays de lAdour | And 13 more authors.
Marine Pollution Bulletin | Year: 2011

Phytoplankton diversity, primary and bacterial production, nutrients and metallic contaminants were measured during the wet season (July) and dry season (March) in the Bach Dang Estuary, a sub-estuary of the Red River system, Northern Vietnam. Using canonical correspondence analysis we show that phytoplankton community structure is potentially influenced by both organometallic species (Hg and Sn) and inorganic metal (Hg) concentrations. During March, dissolved methylmercury and inorganic mercury were important factors for determining phytoplankton community composition at most of the stations. In contrast, during July, low salinity phytoplankton community composition was associated with particulate methylmercury concentrations, whereas phytoplankton community composition in the higher salinity stations was more related to dissolved inorganic mercury and dissolved mono and tributyltin concentrations. These results highlight the importance of taking into account factors other than light and nutrients, such as eco-toxic heavy metals, in understanding phytoplankton diversity and activity in estuarine ecosystems. © 2011 Elsevier Ltd. Source


Thanh N.V.,Vietnam Academy of Science and Technology | Ngoc N.T.,Vietnam Academy of Science and Technology | Anh H.L.T.,Vietnam Academy of Science and Technology | Thung D.C.,Institute of Marine Environment and Resources IMER | And 5 more authors.
Journal of Asian Natural Products Research | Year: 2016

A methanol extract of the soft coral Sinularia microspiculata revealed five sterols, including two new compounds. Using combined chromatographic and spectroscopic experiments, the new compounds were found to be 7-oxogorgosterol (1) and 16α-hydroxysarcosterol (2). Their structures were determined on the basis of spectroscopic data (1H and 13C NMR, HSQC, HMBC, 1H-1H COSY, NOESY, and FT-ICR-MS) and by comparing obtained results to the values indicated in previous studies. Among the isolated compounds, 3 showed weak cytotoxic effects against HL-60 (IC50  =  89.02  ±  9.93 μM) cell line, whereas 5 was weakly active against HL-60 (IC50  =  82.80  ±  13.65 μM) and SK-Mel2 (IC50  =  72.32  ±  1.30 μM) cell lines. © 2016 Informa UK Limited, trading as Taylor & Francis Group Source


Ngoan B.T.,Vietnam Academy of Science and Technology | Hanh T.T.H.,Vietnam Academy of Science and Technology | Vien L.T.,Vietnam Academy of Science and Technology | Diep C.N.,Vietnam Academy of Science and Technology | And 9 more authors.
Journal of Asian Natural Products Research | Year: 2015

Using combined chromatographic methods, two asterosaponins (compounds 1 and 2), including a new compound novaeguinoside E (compound 1), and six glycosylated polyhydroxysteroids (compounds 3–8) were isolated from a methanol extract of the starfish Culcita novaeguineae. Their structures were determined on the basis of spectroscopic data (1H and 13C NMR, HSQC, HMBC, 1H–1H COSY, ROESY, and HRESI-MS) and by comparison with the literature values. The new compound 1 represents the third example of asterosaponins containing the 5α-cholesta-9(1l)-en-3β,6α,20,22-tetraol aglycone. Among isolated compounds, 4–7 exhibited moderate to weak cytotoxic activities against five human cancer cell lines such as Hep-G2 (hepatoma), KB (epidermoid carcinoma), LNCaP (prostate cancer), MCF7 (breast cancer), and SK-Mel2 (melanoma). © 2015 Taylor & Francis Source


Cuong N.X.,Vietnam Academy of Science and Technology | Vien L.T.,Vietnam Academy of Science and Technology | Hong Hanh T.T.,Vietnam Academy of Science and Technology | Thao N.P.,Vietnam Academy of Science and Technology | And 6 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2015

Abstract Seven holostane-type triterpene saponins (1-7), including five new compounds namely cercodemasoides A-E (2-6), were isolated from the sea cucumber Cercodemas anceps. Their structures were elucidated on the basis of spectroscopic evidence including HR ESI MS, ESI MS/MS, 1D and 2D NMR. The cytotoxic effects of isolated compounds were evaluated by SRB method on five human cancer cell lines including Hep-G2 (hepatoma cancer), KB (epidermoid carcinoma), LNCaP (prostate cancer), MCF7 (breast cancer), and SK-Mel2 (melanoma). Compounds 1-7 showed potent cytotoxicity on five tested cancer cell lines with IC50 values ranging from 0.03 ± 0.01 to 7.36 ± 0.46 μM. With respect to the potent cytotoxicity of the isolated saponins, further studies are required to confirm efficacy in vivo and the mechanism of cytotoxic effects. © 2015 Elsevier Ltd. Source


Bettarel Y.,Montpellier University | Bouvier T.,Montpellier University | Agis M.,Montpellier University | Bouvier C.,Montpellier University | And 10 more authors.
Microbial Ecology | Year: 2011

Although the structure and dynamics of planktonic viruses in freshwater and seawater environments are relatively well documented, little is known about the occurrence and activity of these viruses in estuaries, especially in the tropics. Viral abundance, life strategies, and morphotype distribution were examined in the Bach Dang Estuary (Vietnam) during the dry season in 2009. The abundance of both viruses and their prokaryotic hosts decreased significantly from upstream to downstream, probably as the result of nutrient dilution and osmotic stress faced by the freshwater communities. The antibiotic mitomycin-C revealed that the fraction of lysogenic cells was substantially higher in the lower seawater part of the estuary (max 27.1%) than in the upper freshwater area where no inducible lysogens were observed. The question of whether there is a massive, continuous induction of marine lysogens caused by the mixing with freshwater is considered. Conversely, the production of lytic viruses declined as salinity increased, indicating a spatial succession of viral life strategies in this tropical estuary. Icosahedral tailless viruses with capsids smaller than 60 nm dominated the viral assemblage throughout the estuary (63.0% to 72.1% of the total viral counts), and their distribution was positively correlated with that of viral lytic production. Interestingly, the gamma-proteobacteria explained a significant portion of the variance in the < 60 nm and 60 to 90 nm tailless viruses (92% and 80%, respectively), and in the Myoviridae (73%). Also, 60% of the variance of the tailless larger viruses (> 90 nm) was explained by the beta-proteobacteria. Overall, these results support the view that the environment, through selection mechanisms, probably shapes the structure of the prokaryotic community. This might be in turn a source of selection for the virioplankton community via specific affiliation favoring particular morphotypes and life strategies. © 2011 Springer Science+Business Media, LLC. Source

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