Phan N.H.T.,Vietnam Academy of Science and Technology |
Thuan N.T.D.,Vietnam Academy of Science and Technology |
Ngoc N.T.,Institute of Marine Biochemistry IMBC |
Thao N.P.,Chungnam National University |
And 8 more authors.
Chemical and Pharmaceutical Bulletin | Year: 2015
Five new tirucallane saponins, paramignyosides A-E (1-5), were isolated from the water fraction of the Paramignya scandens stem and leaves. Their structures were elucidated on the basis of spectroscopic evidence including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and one dimensional (1D)- and 2D-NMR. The effects of isolated compounds on pro-inflammatory cytokines were evaluated by measuring the production of interleukin (IL)-12 p40, IL-6, and tumor necrosis factor-α (TNF-α) in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs). Paramignyoside C (3) exhibited selective and potent inhibitory effect (IC50=5.03±0.19 μM) on the production of IL-12 p40 comparable to that of the positive control, SB203580 (IC50=5.00×0.16 μM). Further studies are required to confirm efficacy in vivo and the mechanism of anti-inflammatory effects. © 2015 The Pharmaceutical Society of Japan.
Thao D.T.,Vietnam Academy of Science and Technology |
Phuong D.T.,Vietnam Academy of Science and Technology |
Hanh T.T.H.,Institute of Marine Biochemistry IMBC |
Thao N.P.,Institute of Marine Biochemistry IMBC |
And 3 more authors.
Journal of Asian Natural Products Research | Year: 2014
Various chromatographic separations of the aerial parts of Scutellaria barbata afforded two new neoclerodane diterpenoids, scutebatas S and T (1 and 2), along with scutebata D (3). Their structures were elucidated by spectroscopic methods including high-resolution electrospray ionization mass spectrometry, 1D and 2D NMR and comparison with the literature values. Compounds 1 and 3 exhibited moderate cytotoxic activities against HL-60 (promyeloblast) human cancer cells. Weak cytotoxic effects toward four tested human cancer cell lines including KB (epidermoid carcinoma), LU-1 (lung adenocarcinoma), MCF7 (breast cancer), and Hep-G2 (hepatoma cancer) were observed for 1 and 3; whereas 2 was inactive on all five tested cell lines. © 2013 Taylor & Francis.