Institute of Marine Biochemistry

Hanoi, Vietnam

Institute of Marine Biochemistry

Hanoi, Vietnam
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Phi T.D.,Hanoi University of Science and Technology | Doan Thi Mai H.,Institute of Marine Biochemistry | Tran V.H.,Institute of Marine Biochemistry | Truong B.N.,Institute of Marine Biochemistry | And 4 more authors.
MedChemComm | Year: 2017

Starting from d-glycero-d-gulo-heptonic acid γ-lactone and amino acids, a number of diastereoisomeric bengamide analogues were synthesized. Optimization of the reaction conditions revealed that microwave irradiation assistance is a powerful method for the preparation of aminolactams, as well as for the coupling reactions of the lactone 5 with aminolactams. Cytotoxic activity evaluation against six cancer cell lines (KB, HepG2, LU1, MCF7, HL60, and Hela) demonstrated that the configuration of C-2′ seems to be critical for the cytotoxic activity of compounds 8b (2′R) and 8a (2′S). Additionally, comparison of cytotoxicity of the protected acetonide compounds with that of their corresponding deprotected bengamide analogues suggested that the flexibility of the ketide side chain should be required for their cytotoxic activity. © The Royal Society of Chemistry.


Nguyen T.T.,Institute of Marine Biochemistry | Truong B.N.,Institute of Marine Biochemistry | Mai H.D.T.,Institute of Marine Biochemistry | Litaudon M.,University Paris - Sud | And 6 more authors.
Natural Product Communications | Year: 2017

Three new compounds, hydnohainanic acid (1), and hydnohainanin A (2) and B (3) were isolated from the fruits of Hydnocarpus hainanensis (Achariaceae). Their structures were determined by spectroscopic analysis, including 2D NMR, and MS. Compounds 1-3 were evaluated for their cytotoxic activity against the KB cell line. Compound 1 had a moderate cytotoxicity with an IC50 value of 32.5 μg/mL, while the two remaining compounds did not exhibit inhibition, even at a concentration of 128 μg/mL.


Oanh N.T.T.,Institute of Marine Biochemistry | Tung T.H.,Institute of Marine Biochemistry | Hue C.T.,Institute of Marine Biochemistry | Thanh L.N.,Institute of Marine Biochemistry | And 2 more authors.
Natural Product Communications | Year: 2017

A new azaoxoaporphine alkaloid, 8,9-dimethoxysampangine (1), and a new naphthyridine alkaloid, 7-methoxy-8-hydroxyeupolauridine (2), along with two known azaoxoaporphine alkaloids, sampangine (3) and 9-methoxysampangine (4), were isolated from the EtOAc extract of the barks of Polyalthia nemoralis. Their structures were established on the basis of spectral evidences. Compound 1 exhibited significant cytotoxicity against KB, MCF7, LU-1, HepG2, LNCap, SW626 and SW480 cancer cell lines with IC50 values in the range of 5.06.,b0.04-7.61.,b0.06 μM.


Phi T.D.,Institute of Marine biochemistry | Pham V.C.,Institute of Marine biochemistry | Thi Mai H.D.,Institute of Marine biochemistry | Litaudon M.,CNRS Natural Product Chemistry Institute | And 3 more authors.
Journal of Natural Products | Year: 2011

Four new steroids, 3-epi-gitingensine (1), N-acetylgitingensine (6), kibalaurifoline (7) and kibalaurifenone (8), along with the known para-allarine (2), 7α-hydroxypara-allarine (3), gitingensine (4), and N-methylgitingensine (5) were isolated from the lea-es of Kibatalia laurifolia. Their structures were determined primarily from mass spectrometry and 2D NMR analyses. On the basis of the known absolute configurations of 2 and 4, the absolute configurations of the new compounds were proposed. Due to the structural relationships of compounds 1-8, a biosynthetic pathway was suggested. Compound 2 was cytotoxic to KB cells (IC 50 12.8 μM), followed by 1 with IC 50 21.2 μM. (Chemical Equation Presented). © 2011 The American Chemical Society and American Society of Pharmacognosy.


Tai B.H.,Chungnam National University | Tai B.H.,Institute of Natural Products Chemistry | Nhiem N.X.,Chungnam National University | Nhiem N.X.,Institute of Marine Biochemistry | And 8 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2011

A new iridoid, named methylscutelloside (1) together with 19 known compounds belonging to the iridoids (2-4), monoterpenoids (5), flavonoids (6-8), triterpenoids (9-14), and phenylethanoids (15-20) were isolated from the flowers of Buddleja officinalis. Their chemical structures were elucidated on the basis of physicochemical properties, and by spectroscopic methods including 1D, 2D NMR, and MS. All isolated compounds were tested in vitro for their effects on the proliferation of rat aortic vascular smooth muscle cells (VSMCs). Among them, iridoids were the main active components and showed significant inhibitory effects on PDGF-BB-induced proliferation in rat aortic VSMCs. © 2011 Elsevier Ltd. All rights reserved. © 2011 Elsevier Ltd. All rights reserved.


Ho D.V.,Hue University | Kodama T.,University of Toyama | Le H.T.B.,Hue University | Phan K.V.,Institute of Marine Biochemistry | And 8 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2015

Abstract A new polyoxygenated cyclohexene, (-)-3-O-debenzoylzeylenone (1), and a new megastigmane glycoside, grandionoside A (2), were isolated from the aerial parts of Uvaria grandiflora collected in Vietnam, together with ten known compounds including polyoxygenated cyclohexenes (3-6), a triterpenoid (7), an alkaloid (8), a long chain alcohol (9), hexenyl glycopyranoside (10), and saponins (11-12). Their chemical structures were elucidated by a combination of extensive NMR spectroscopy with X-ray crystallographic analysis for 1, and chemical conversion for 2. Compound 1 exhibited significant cytotoxicity against the LU-1 and SK-Mel-2 cell lines with IC50 values of 4.68 and 3.63 μM, respectively. Remarkably, the cytotoxicity of 12 against the LU-1, KB, Hep-G2, MKN-7, and SW-480 cell lines was comparable to that of ellipticine, the positive control, with IC50 values ranging from 1.24 to 1.60 μM. © 2015 Elsevier Ltd.


PubMed | Institute of Biotechnology, Tokushima Bunri University, University of Toyama, Institute of Marine Biochemistry and 3 more.
Type: Journal Article | Journal: Bioorganic & medicinal chemistry letters | Year: 2015

A new polyoxygenated cyclohexene, (-)-3-O-debenzoylzeylenone (1), and a new megastigmane glycoside, grandionoside A (2), were isolated from the aerial parts of Uvaria grandiflora collected in Vietnam, together with ten known compounds including polyoxygenated cyclohexenes (3-6), a triterpenoid (7), an alkaloid (8), a long chain alcohol (9), hexenyl glycopyranoside (10), and saponins (11-12). Their chemical structures were elucidated by a combination of extensive NMR spectroscopy with X-ray crystallographic analysis for 1, and chemical conversion for 2. Compound 1 exhibited significant cytotoxicity against the LU-1 and SK-Mel-2 cell lines with IC50 values of 4.68 and 3.63 M, respectively. Remarkably, the cytotoxicity of 12 against the LU-1, KB, Hep-G2, MKN-7, and SW-480 cell lines was comparable to that of ellipticine, the positive control, with IC50 values ranging from 1.24 to 1.60 M.


Le H.T.,National Institute of Medicinal Materials | Ha D.T.,National Institute of Medicinal Materials | Minh C.T.A.,Yeungnam University | Kim T.H.,Yeungnam University | And 3 more authors.
Archives of Pharmacal Research | Year: 2012

Phytochemical investigation of the stem barks of Canarium bengalense (Burseraceace) resulted in the isolation of a new flavone glycoside (5) together with six known compounds (1-4, 6, and 7). The chemical structure of the new compound was elucidated as 3′-hydroxy-7,4′-dimethoxyflavone-5-O- α-L-arabinofuranosyl-(1→6)-β-D-glucopyranoside by means of 1D and 2D NMR ( 1H- 1H COSY, HMQC, and HMBC) and MS analyses. To evaluate the in vitro cytoprotective effect, the isolates (1-7) were tested against hydrogen peroxide (H 2O 2)-induced damage in primary cultured hepatocytes. The viability of hepatocytes was increased by treatment with each compound, except compound 1. Compounds 3, 4, and 7 exerted cytoprotective effects comparable to curcumin, the positive control. Our results suggest that the cytoprotective constituents of C. bengalense may contribute to its traditional use in the treatment of tumor and liver damage. © 2012 The Pharmaceutical Society of Korea and Springer Netherlands.


Nhiem N.X.,Chungnam National University | Nhiem N.X.,Institute of Marine Biochemistry | Kim K.C.,Jeju National University | Kim A.-D.,Jeju National University | And 9 more authors.
Journal of Asian Natural Products Research | Year: 2011

By various chromatographic methods, one new phenylpropanoid, acanthopanic acid (1), and three known compounds, 1,2-O-dicaffeoylcyclopenta-3-ol (2), (4S)-α- terpineol 8-O-β- D-glucopyranoside (3), and rutin (4), were isolated from the methanol extract of the Acanthopanax koreanum leaves. Their structures were elucidated on the basis of spectroscopic analyses, and their antioxidant activities were evaluated by the intracellular reactive oxygen species (ROS) radical scavenging 2',7'-dichlorofluorescein diacetate assay. Among them, compounds 1, 2, and 4 showed significant scavenging capacity with IC50 values of 3.8, 2.6, and 2.9μM, respectively, and compound 3 showed weak scavenging capacity with the inhibition rate of 37% at 40μM. © 2011 Taylor & Francis.


Van N.T.H.,Vietnam Academy of Science and Technology | Vien T.A.,Industrial University of Ho Chi Minh City | Nhiem N.X.,Institute of Marine Biochemistry | Van Kiem P.,Institute of Marine Biochemistry | And 9 more authors.
Natural Product Communications | Year: 2014

Using a combination of chromatographic methods, one new flavonol glycoside, myricetin 3,7-di-O-α-L-rhamnopyranoside (1), and nine known compounds myricitrin (2), quercetin 3,7-di-O-α-L-rhamnopyranoside (3), quercitrin (4), desmanthin-1 (5), myricetin 3-O-(3″-O-galloyl)-α-L- rhamnopyranoside (6), (+)-catechin (7), benzyl O-β-D-glucopyranoside (8), 2-phenylethyl O-β-D-glucopyranoside (9), and corilagin (10) were isolated from the leaves of Ardisia splendens Pit. Based on an in vitro test against Coxsackie viruses A16 by SRB assay, only compounds 2, 5, and 10 exhibited activity against Coxsackie viruses A16 with IC50 values of 40.1, 32.2, and 30.5 μM, respectively. This result suggested that compounds 2, 5, and 10 might be potential agents for treating hand, foot and mouth diseases.

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