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Novosibirsk, Russia

Bazila Banu A.,Velammal College of Engineering and Technology | Appavu Alias Balamurugan S.,k-Technology | Thirumalaikolundu Subramanian P.,Institute of Internal Medicine
Journal of Biological Sciences | Year: 2013

In this study detection of association between drugs and Adverse Drug Reactions (ADRs), is carried out by using Naive Bayes method. Adverse event reports submitted to the United States Food and Drug Administration (FDA) were reviewed to find top 10 drugs causing frequent ADRs for a particular period. The main objective of this paper is to evaluate drugs associated with list of outcomes provided by FDA. For a particular category of disease, drugs creating outcomes are ranked using Naive Bayes method. FDA represents ADRs in Preferred Terms(PT) by referring Medical Dictionary for Regulatory Activities (MedDRA). To create conceptual hierarchy System Organ Class (SOC) present in MedDRA is mapped with low level Preferred Terms (PT) in FDA dataset. For each SOC the drugs are ranked based on posterior probability obtained by Naive Bayes method. Data mining model has been built to analyse drugs associated with outcome for a disease category in SOC level. The newly designed tool is user friendly and applicable to pharmaceutical industries, policy makers and practitioners. © 2013 Asian Network for Scientific Information. Source

Rajendiran C.,Institute of Internal Medicine
The Journal of the Association of Physicians of India | Year: 2012

Bee stings are commonly encountered worldwide. Various manifestations after bee sting have been described. Local reactions are common. Unusually, manifestations like vomiting, diarrhea, dyspnea, generalized edema, acute renal failure, hypotension and collapse may occur. Rarely vasculitis, serum sickness, neuritis and encephalitis have been described which generally develop days to weeks after a sting. We report a case of a 25-year-old male who developed left sided monoparesis and transient visual loss following multiple bee stings. Unlike the previous case reports, in our case there has been involvement of both the anterior circulation and posterior circulation territory to the brain. We report this case due to it's rarity. Source

Yang C.-P.,Kuang Tien General Hospital | Yang C.-P.,Hungkuang University | Chen Y.-T.,National Yang Ming University | Chen Y.-T.,Institute of Internal Medicine | And 4 more authors.
Ophthalmology | Year: 2016

To determine whether migraine is associated with an increased risk of developing ocular motor cranial nerve palsies (OMCNP). Design: Nationwide retrospective cohort study. Participants: Medical records of patients with migraine who were entered in the National Health Insurance Research Database (NHIRD) between 2005 and 2009 were retrieved from the NHIRD in Taiwan. Two cohorts were selected: patients with migraine (n = 138 907) and propensity scoreematched controls (n = 138 907). Main Outcome Measures: Cohorts were followed until the end of 2010, death, or occurrence of cranial nerve (CN)3, CN4, or CN6 palsies. A Cox proportional hazards regression model was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs), which were used to compare to the risk of developing CN3, CN4, and CN6 palsy between cohorts. Results: After a mean follow-up period of 3.1 years (range, 1e6 years), the migraine cohort exhibited a greater risk of developing subsequent CN3, CN4, and CN6 palsies compared with the control cohort (HR, 2.67, P < 0.001; HR, 4.23, P < 0.001; HR, 3.37; P < 0.001). This finding was maintained after excluding potential confounders during sensitivity tests. Moreover, the significant association between migraine and OMCNP remained after we adjusted for potential risk factors of microvascular ischemia. However, different migraine subtypes showed no significant differences. Conclusions: Migraine is an unrecognized risk factor for OMCNP development in adults. Further studies are needed to validate our findings and to delineate the exact pathophysiologic mechanisms linking migraine and OMCNP. © 2016 American Academy of Ophthalmology. Source

Linkov F.,University of Pittsburgh | Shubnikov E.,Institute of Internal Medicine | Padilla N.,University of Guanajuato | McCallum A.,NHS Lothian | LaPorte R.,University of Pittsburgh
Public Health | Year: 2012

The focus of this symposium was worldwide prevention of chronic disease through the use of inexpensive Internet pathways, as demonstrated with the Supercourse project, and other initiatives, including promoting mobile phone technology (m-health). This symposium highlighted the need to use the Supercourse to prevent cancer and other chronic diseases. It also highlighted several components of the Supercourse library, including the former Soviet Union network, the Latin American network, and some other initiatives. © 2011 The Royal Society for Public Health. Source

Meenakshisundaram R.,Institute of Internal Medicine | Sweni S.,Debrecen University
Pediatric Cardiology | Year: 2010

Cardiac involvement in children with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) is known but less often considered. Our objectives were to determine cardiac manifestations in pediatric HIV/AIDS and estimate the cardiac isoform of alpha-2 macroglobulin [CA2M] among them. We recruited 67 pediatric HIV/AIDS patients, 37 with cardiac involvement (group A) and 30 without (group B); 30 cardiac patients without HIV infection (group C); and 30 healthy control subjects without any comorbid illness (group D). Their sociodemographic and clinical information were collected along with echocardiogram and blood for CA2M. Patterns of cardiac involvement in HIV/AIDS (group A) were pericardial effusion, left ventricular dysfunction, pulmonary hypertension, and cardiomyopathy and observed in 43, 30, 16, and 11% of subjects, respectively. CA2M levels among groups A, B, C, and D were 132.67 ± 5.01, 41.25 ± 3.33, 65.99 ± 2.48 and 29.59 ± 2.76 lgm/ml, respectively. It was elevated significantly in group A (P = 0.001; 95% confidence interval [CI] 87.27-95.55) compared with group B and was independent of sex and CD4 count among HIV/AIDS subjects. Although CA2M was elevated in HIV-negative patients with cardiac involvement, it was much less than in HIV/AIDS subjects with cardiac involvement (P = 0.001; 95% CI 62.54-70.82). Because CA2M is a cardiac biomarker, further research with larger population is needed to ascertain the role of CA2M as a diagnostic/therapeutic/prognostic marker in cardiac patients with and without HIV infection. © Springer Science+Business Media, LLC 2009. Source

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