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Limeira A.B.,Federal University of Pernambuco | Aguiar C.M.,Federal University of Pernambuco | De Lima Bezerra N.S.,Federal University of Pernambuco | De Lima Bezerra N.S.,Institute of Integrative Medicine | Camara A.C.,Federal University of Pernambuco
Journal of Dentistry for Children | Year: 2014

Purpose: The purpose of this study was to evaluate the association between breastfeeding duration and the subsequent occurrence of posterior crossbite in Brazilian children.Methods: A cross-sectional study was conducted involving 714 six- to nine-year-old children. A questionnaire was completed by mothers or guardians of the children concerning the length of time they were exclusively breast-fed and the breast-feeding duration. A clinical examination of each child was conducted to detect posterior crossbite. Data were analyzed using Pearson's chi-square test at a five percent significance level.Results: There was a posterior crossbite prevalence of approximately 15 percent. There was no statistically significant association between posterior crossbite and age or gender (P>.05). The prevalence of posterior crossbite was higher among children who were not breast-fed (28 percent) than among breast-fed children (13 percent). There was a significant association between posterior crossbite and the length of time that children were exclusively breast-fed and the breast-feeding duration (P<.05 percent).Conclusion: The prevalence of posterior crossbite gradually decreased as exclusive breast-feeding duration increased, and there was a relationship between breast-feeding duration and the occurrence of posterior crossbite.


Limeira A.B.,Federal University of Pernambuco | Aguiar C.M.,Federal University of Pernambuco | De Lima Bezerra N.S.,Federal University of Pernambuco | De Lima Bezerra N.S.,Institute of Integrative Medicine | Camara A.C.,State University of Paraíba
European Journal of Pediatrics | Year: 2013

The aims of the present study were to evaluate the association between breastfeeding and breathing development and to investigate associations between breastfeeding duration and the breathing patterns in children. A crosssectional study was carried out at the Institute of Integrative Medicine Professor Fernando Figueira, Recife, Brazil, with a random sample of 732 children aged between 6 and 9 years. Breastfeeding and breathing patterns were identified using a questionnaire that was filled out by mothers or guardians, and a clinical examination of the children. Data were analyzed statistically by Pearson's chi-square test at 5 % significance level. The prevalence of mouth breathing was 48 %, whereas 52 % of the children were nasal breathers. Six hundred-forty children were breastfed; 46.2 % of them were mouth breathers and 53.8 % were nasal breathers. Ninety-two children were not breastfed; 59.8 % of them were mouth breathers and 40.2 % were nasal breathers. Breastfeeding for 24 months or more, as well as exclusive breastfeeding in the first 6 months, was associated with the development of nasal breathing. Conclusions Extended breastfeeding was associated with correct development of the breathing pattern. © Springer-Verlag Berlin Heidelberg 2012.


Kroz M.,Research Institute Havelhohe FIH | Kroz M.,Community Hospital Havelhohe | Kroz M.,Charité - Medical University of Berlin | Kroz M.,Institute of Integrative Medicine | And 10 more authors.
European Journal of Cancer Care | Year: 2015

Cancer-related fatigue (CRF) is a burdensome symptom for breast cancer (BC) patients. In this pilot study, we tested several questionnaires as predictors for treatment responsiveness, along with the implementation of a multimodal therapy concept consisting of sleep, psycho-education, eurythmy, painting therapy and standard aerobic training. At the Community Hospital Havelhöhe and the Hannover Medical School, 31 BC patients suffering from CRF could be evaluated in a 10-week intervention study. CRF was assessed by the Cancer Fatigue Scale (CFS-D). Further questionnaires were the Pittsburgh Sleep Quality Index, the autonomic regulation scale, Self-Regulation Scale (SRS), the Internal Coherence Scale (ICS) and the European Organization of Research and Treatment Health-Related Quality of Life Core Questionnaire scale. We estimated the regression coefficients of all scales on CFS-D by simple and multiple linear regression analyses and compared regression slopes and variances between the different questionnaires on CFS-D at the end of treatment. We found a significant impact of SRS and ICS at baseline on CFS-D at the end of the intervention [absolute standardised multiple regression coefficient values ranging from 0.319 (SRS) to 0.269 (ICS)] but not for the other questionnaires. In conclusion, this study supports the hypothesis that the SRS or ICS measuring adaptive capacities could be more appropriate as outcome predictors than classical questionnaire measures in complex interventions studies. © 2015 John Wiley & Sons Ltd.


Lima C.G.M.G.,University of Sao Paulo | Chahud F.,University of Sao Paulo | Paiva C.J.K.,Institute of Integrative Medicine | Nebl D.,Institute of Integrative Medicine | And 2 more authors.
Ophthalmic Plastic and Reconstructive Surgery | Year: 2014

Primary adenocarcinoma of the lacrimal gland with sebaceous differentiation is an extremely rare tumor. Only 11 cases have been reported in the literature, none in children. A 4-year-old girl presented with a rapidly progressing mass in the left lacrimal gland fossa. An incisional biopsy followed by partial orbital exenteration confirmed the diagnosis of adenocarcinoma with sebaceous cell differentiation. Currently, no previous reports of this malignancy in childhood have been published. This case underscores the necessity of expanding the presenting age that adenocarcinomas with sebaceous differentiation of the lacrimal gland can occur. © 2014 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc.


Choudhary S.P.,Jammu University | Kanwar M.,Guru Nanak Dev University | Bhardwaj R.,Guru Nanak Dev University | Gupta B.D.,Institute of Integrative Medicine | Gupta R.K.,Institute of Integrative Medicine
Chemosphere | Year: 2011

The present investigation determined the effects of epibrassinolide (EBL) on the levels of indole-3-acetic acid (IAA), abscisic acid (ABA), and polyamine (PA) and antioxidant potential of 7-d old Raphanus sativus L. cv. 'Pusa chetki' seedlings grown under Cr (VI) metal stress. Reduced titers of free (0.767μgg-1 FW) and bound (0.545μgg-1 FW) IAA in Cr (VI) stressed seedlings were observed over untreated control. Supplementations of EBL to Cr (VI) stressed seedlings were able to enhance both free (2.14-5.68μgg-1 FW) and bound IAA (2.45-7.78μgg-1 FW) concentrations in comparison to Cr (VI) metal treatment alone. Significant rise in free (13.49μgg-1 FW) and bound (12.17μgg-1 FW) ABA contents were noticed for Cr (VI) stressed seedlings when compared to untreated control. No significant increase in ABA contents were recorded for Cr (VI) stressed seedlings upon supplementation with EBL over Cr (VI) treatment alone. A significant increase in Put (18.40μgg-1 FW) and Cad (9.08μgg-1 FW) contents were found for 10-9M EBL plus Cr (VI) metal treatments when compared to Cr (VI) treatment alone. Spermidine (Spd) contents were found to decline significantly for EBL treatment alone or when supplemented with Cr (VI) treatments over untreated controls and Cr (VI) treatment alone. Antioxidant levels were found to enhance, with glutathione (57.98mgg-1 FW), proline (4.97mgg-1 FW), glycinebetaine (39.01μmolmL-1), ascorbic acid (3.17mgg-1 FW) and phytochelatins (65.69μmolg-1 FW) contents noted for EBL supplemented to Cr (VI) metal solution over Cr (VI) treatment alone. Reduced activities of guaiacol peroxidase (0.391 Umg-1 protein) and catalase (0.221Umg-1 protein) and enhanced activities of glutathione reductase (7.14Umg-1 protein), superoxide dismutase (15.20Umg-1 protein) and ascorbate peroxidase (4.31Umg-1 protein) were observed in seedlings treated with EBL plus Cr (VI) over Cr metal treatment alone. Reduced MDA (2.55μmolg-1 FW) and H2O2 (33.24μmolg-1 FW) contents were recorded for 10-9M EBL supplemented to Cr (VI) stress over Cr (VI) treatment alone. Enhancement in free radical scavenging potential as indicated by higher values of 1,1-diphenylpicrylhydrazyl, deoxyribose and reducing power activity assays, and increased levels of phenols and soluble sugars also showed significant influence of EBL in alleviating Cr (VI) stress in radish seedlings. © 2011 Elsevier Ltd.


Zhao Q.,Shanghai University of Traditional Chinese Medicine | Cai D.,Institute of Integrative Medicine | Cai D.,Fudan University | Bai Y.,Shanghai University of Traditional Chinese Medicine
International Journal of Molecular Medicine | Year: 2013

The monoamine oxidase type-B (MAO-B) inhibitor, selegiline, is often recommended as a first-line treatment for Parkinson's disease (PD) and has been shwon to possess neuroprotective effects. The aim of the present study was to determine whether selegiline increases the levels of the neurotrophic factors (NTFs), glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF), and whether it rescues motor dysfunction and the loss of dopaminergic neurons in mice with 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced lesions. We found that the oral administration of selegiline (1.0 mg/kg/day for 14 days) successfully suppressed the MPTP-induced reduction of nigral dopaminergic neurons and striatal fibers (192.68 and 162.76% of MPTP-exposed animals, respectively; both P<0.001). Moreover, improvements in gait dysfunction were observed after 7 and 14 days of a low dose of selegiline that is reported not to inhibit MAO-B. Furthermore, there was a significant increase in GDNF and BDNF mRNA (2.10 and 2.75-fold) and protein levels (143.53 and 157.05%) in the selegiline-treated mice compared with the saline-treated MPTP-exposed mice. In addition, the Bax/Bcl-2 gene and protein expression ratios were significantly increased in the MPTP-exposed mice, and this effect was reversed by selegiline. Correlation analysis revealed that gait measurement and GDNF/BDNF levels positively correlated with the number of dopaminergic neurons. These findings demonstrate that selegiline has neurorescue effects that are possibly associated with the induction of NTFs and anti-apoptotic genes.


Choudhary S.P.,Jammu University | Bhardwaj R.,Guru Nanak Dev University | Gupta B.D.,Institute of Integrative Medicine | Dutt P.,Institute of Integrative Medicine | And 3 more authors.
Physiologia Plantarum | Year: 2010

In the present study, the effects of epibrassinolide (EBL) on indole-3-acetic acid (IAA), abscisic acid (ABA) and polyamine (PA) tissue concentrations and antioxidant potential of 7-day-old Raphanus sativus L. cv. 'Pusa chetki' seedlings grown under Cu stress were investigated. EBL treatment alone or in combination with Cu enhanced free and bound IAA titers when compared with the metal alone. Modest increases in free and bound ABA contents were observed for EBL treatment alone. However, the combination of EBL with Cu caused major increases in both forms of ABA, over Cu alone. Among the PAs analyzed, only putrescine and cadaverine concentrations were enhanced by EBL treatment alone. By contrast, a significant decline in putrescine and spermine contents was found in seedlings treated with EBL plus Cu. EBL treatments alone or in combination with Cu enhanced activities of guaiacol peroxidase (EC1.11.1.7), catalase (EC 1.11.1.6), superoxide dismutase (EC 1.15.1.1) and glutathione reductase (EC 1.6.4.2) and protein contents in comparison with metal and control treatments. A major decrease in malondialdehyde content was also recorded for EBL treatments with or without Cu. An increase in phytochelatin content was also observed in seedlings treated with EBL alone or in combination with Cu. Major improvement in radical scavenging activities, as attested by the antioxidant activity assay using DPPH (1,1-diphenylpicrylhydrazyl), and elevated deoxyribose and reducing powers, along with increased contents of ascorbic acid, total phenols and proline, also suggest a major influence of EBL application in mitigating copper-induced oxidative stress in radish seedlings. © Physiologia Plantarum 2010.


Choudhary S.P.,Guru Nanak Dev University | Bhardwaj R.,Guru Nanak Dev University | Gupta B.D.,Guru Nanak Dev University | Gupta B.D.,Institute of integrative Medicine | And 6 more authors.
Acta Physiologiae Plantarum | Year: 2011

The present investigation recorded significant restoration of seedling growth (root length, shoot length and fresh weight) upon application of 24-epibrassinolide (EBL) and putrescine (Put) to 7-day-old seedlings of Raphanus sativus L. cv. Pusa chetki grown under copper (Cu) ion stress. EBL and Put with/or without Cu ion treated seedlings showed increased titers of ascorbic acid, total phenols and proline when compared with Cu-stressed seedlings. Differential responses in the activities of guaiacol peroxidase (GPOX) and catalase (CAT) were noted for EBL and Put alone or with/or without Cu ion treatment. Decreased activities of glutathione reductase (GR) and superoxide dismutase (SOD) noted for EBL and Put alone were observed to enhance significantly when applied in combination with Cu ion solution. A remarkable decrease in malondialdehyde contents was observed in seedlings treated with EBL and Put alone and with/or without Cu ion stress. Enhanced free radical scavenging activities were also recorded for seedlings given EBL and Put alone or in combination over Cu ion stressed seedlings. Maximum DPPH activity was observed in seedlings treated with Put and EBL 10-9 M + Put. Significant enhancements in deoxyribose and reducing power activities were too recorded for Put, EBL and Put + 10-9M EBL treatments. Improved seedling growth, antioxidant levels (ascorbic acid, total phenols and proline) and enzymic (GPOX, CAT, SOD and GR) activities and free radical scavenging capacities along with reduced membrane damage in seedlings given EBL and Put with/or without Cu stress suggests significant and positive interactions of EBL and Put in alleviating the Cu ion induced oxidative damage in radish seedlings. © 2010 Franciszek Górski Institute of Plant Physiology, Polish Academy of Sciences, Kraków.


Ciaramella A.,Institute of Integrative Medicine | Poli P.,Pain Therapy Unit
Journal of Nervous and Mental Disease | Year: 2015

This retrospective study investigated the influence of psychiatric comorbidity on pain perception and coping with pain in tertiary pain clinic patients, 427 treated for chronic low back pain (CLBP) and 629 for other forms of chronic pain (CG). No differences in psychosomatic dimensions were found between the two groups, but Italian Pain Questionnaire dimensions and intensity scores (t = 7.35; p < 0.0001) were higher in CLBP than in CG subjects. According to the Mini-International Neuropsychiatric Interview, CLBP patients also had a higher prevalence of lifetime major depressive episodes (χ2 = 4.96; p < 0.05), dysthymic disorder (χ2 = 4.64; p < 0.05), suicide risk (χ2 = 10.43; p < 0.01), and agoraphobia (χ2 = 6.31; p < 0.05) than CG patients did. The Multidimensional Pain Inventory showed a close association between CLBP and both agoraphobia (χ2 = 3.74; p < 0.05) and dysfunctional coping style (χ2 = 8.25; p < 0.01), which increased disability. Both agoraphobia and lifetime depression were associated with an overall increase in dimensions and pain intensity in CLBP, but not in CG. © 2015 Wolters Kluwer Health, Inc.

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