Institute of Inorganic and Applied Chemistry

Hamburg, Germany

Institute of Inorganic and Applied Chemistry

Hamburg, Germany
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Rehder D.,Institute of Inorganic and Applied Chemistry | Nekola H.,Institute of Inorganic and Applied Chemistry | Behrens A.,Institute of Inorganic and Applied Chemistry | Cramer S.P.,University of California at Davis | Funk T.,University of California at Davis
Zeitschrift fur Anorganische und Allgemeine Chemie | Year: 2013

The bromidovanadium complexes cis-[VIIBr2(bith)] (1) [bith = 1,6-bis(2-benzimidazolyl)-2,5-dithiahexane], cis-[VIIBr 2(pth)] (2a) [pth = 1,6-bis(2-pyridyl)-2,5-dithiahexane], cis-[V IIIBr2(pth)]Br (2b), trans-[VIIBr 2(tmeda)2] (3) (tmeda = tetramethylethylenediamine), fac-[VIIIBr3(9S3)] (4) (9S3 = 1, 4, 7-trithiacyclononane), mer-[VIIIBr3(thf)3] (5) (thf = tetrahydrofurane), and trans-[VIVOBr2(thf) 2H2O] (6) were prepared and characterized by, inter alia, XRD (5, 6), K-edge XAS (3, 4) or L-edge XAS (2a, 2b). The complexes are also addressed in the context of the potential of halogenidovanadium compounds in catalytically conducted reactions, including biogenic processes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Abosede O.O.,University of Pune | Abosede O.O.,University Of Ilorin | Vyas N.A.,University of Pune | Singh S.B.,University of Pune | And 9 more authors.
Dalton Transactions | Year: 2016

Mixed-ligand Cu(ii) complexes of the type [Cu(doxycycline)(L)(H2O)2](NO3)2, where doxycycline = [4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide] and L = 2,2′-bipyridine (bpy, 1), 1,10-phenanthroline (phen, 2), dipyrido[3,2-d:2′,3′-f]quinoxaline (dpq, 3) and dipyrido[3,2-a:2′,3′-c]phenazine (dppz, 4) have been synthesised and characterised by structural, analytical, and spectral methods. The single-crystal X-ray structures of 1 and 2 exhibited two different geometries, distorted square-pyramidal and octahedral respectively as well as different coordination modes of doxycycline. Complexes 2-4 exhibit prominent plasmid DNA cleavage at significantly low concentrations probably by an oxidative mechanism. Matrix Metalloproteinase (MMP-2) inhibition studies revealed that all complexes inhibit MMP-2 similar to doxycycline which is a well-known MMP inhibitor with 3 being the most potent. IC50 values of doxycycline and 1-4 against MCF-7 (human breast cancer) and HeLa cell lines were almost equal in which 3 showed the highest efficiency (IC50 = 0.46 ± 0.05 μM), being consistent with its increased MMP inhibition potency. The antimalarial activities of these complexes against the chloroquine-sensitive Plasmodium falciparum NF54 and chloroquine-resistant Plasmodium falciparum Dd2 strains reveal that complex 3 exhibited a higher activity than artesunate drug against the chloroquine-resistant Dd2 strain. © The Royal Society of Chemistry 2016.

Beretta M.,University of Milan Bicocca | Morell J.,Institute of Inorganic and Applied Chemistry | Sozzani P.,University of Milan Bicocca | Froba M.,Institute of Inorganic and Applied Chemistry
Chemical Communications | Year: 2010

The first synthesis of a new highly ordered divinylaniline-bridged periodic mesoporous organosilica (PMO) with crystal-like pore walls and further chemical modification of the amino groups on the inner surface of the product by a peptide formation reaction with a chiral amino acid are reported. © The Royal Society of Chemistry.

Sann K.,Institute of Physical Chemistry | Roggenbuck J.,Institute of Inorganic and Applied Chemistry | Krawczyk N.,Institute of Physical Chemistry | Buschmann H.,Institute of Physical Chemistry | And 3 more authors.
Electrochimica Acta | Year: 2012

The electrical conductivity of disperse electrolytes was systematically measured as a function of temperature (0 °C to 60 °C) and filler content for different types of fillers with a range of pore geometry, pore structure and specific surface area. As fillers mesoporous silicas SBA-15, MCM-41 and KIT-6 with pore ranges between 3 nm and 15 nm were dispersed in commercially available liquid lithium electrolytes. As electrolytes 1 M of lithium hexafluorophosphate (LiPF 6) in a mixture of ethylene carbonate (EC) and diethylene carbonate (DEC) at the ratio 3:7 (wt/wt) and the same solvent mixture with 0.96 M lithium bis(trifluoromethanesulfon)imide (LiTFSI) were used. No conductivity enhancement could be observed, but with respect to safety aspects the highly viscous disperse pastes might be useful. The conductivity decrease varied considerably for the different fillers. © 2011 Elsevier Ltd. All rights reserved.

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