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Vasiljevic N.D.,University of Belgrade | Vasiljevic N.D.,Institute of Hygiene and Medical Ecology | Simic T.P.,University of Belgrade | Simic T.P.,Institute of Medical and Clinical Biochemistry | And 6 more authors.
Laboratory Medicine | Year: 2014

Objective: Although C-reactive protein (CRP) is among the best cardiovascular disease risk predictors, data regarding the association of CRP and menopause are controversial. In this study, we measured CRP by a high-sensitivity method (hsCRP), cholesterol, lipoproteins, and triglycerides in normal and overweight postmenopausal women. Methods: Body weight, height, waist circumference (WC), hsCRP, total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides, and lipoprotein (a) were measured in 30 normal weight and 60 overweight healthy postmenopausal women. Results: Significantly higher triglyceride and hsCRP levels (P=0.005 and P<0.001 respectively), together with lower HDL-c levels (P=0.001) were found in overweight compared to normal weight women. In the overweight group, positive correlations of hsCRP were observed with age, body mass index and WC (P=0.016, P=0.001, and P<0.001, respectively) and a negative correlation was observed with HDL-c (P=0.007). In the normal weight group, positive correlations were found for hsCRP with age and WC (P=0.023 and P=0.014, respectively). WC was the best predictor of hsCRP level in both groups (P<0.001). Conclusion: Elevated hsCRP levels in conjunction with abnormal lipid profiles may be strongly associated with weight gain in postmenopausal women. Efforts to reduce obesity and inflammation in this group may help correct abnormal levels of hsCRP and lipids. © 2014, American Society of Clinical Pathologists. All rights reserved.


Jovanovic D.,Institute of Public Health of Serbia Dr Milan Jovanovic Batut | Jakovljevic B.,Institute of Hygiene and Medical Ecology | Rasic-Milutinovic Z.,University of Belgrade | Paunovic K.,Institute of Hygiene and Medical Ecology | And 2 more authors.
Environmental Research | Year: 2011

Vojvodina, a northern region of Serbia, belongs to the Pannonian Basin, whose aquifers contain high concentrations of arsenic. This study represents arsenic levels in drinking water in ten municipalities in Serbia. Around 63% of all water samples exceeded Serbian and European standards for arsenic in drinking water. Large variations in arsenic were observed among supply systems. Arsenic concentrations in public water supply systems in Vojvodina were much higher than in other countries in the Pannonian Basin. © 2010 Elsevier Inc.


Lovic D.,Clinic for Internal Disease Inter Medica Nis | Stojanov V.,University of Belgrade | Jakovljevic B.,Institute of Hygiene and Medical Ecology | Krotin M.,University of Belgrade | And 7 more authors.
Journal of Hypertension | Year: 2013

BACKGROUND:: Arterial hypertension (AH) is the most common cardiovascular disease risk factor, affecting between 30 and 50% of the adult population in developed countries. A steady increase of the prevalence of AH by about 60% is expected by year 2025. METHODS:: Serbian Society of Hypertension conducted a prevalence study from February to May 2012 on a sample of 3878 adult respondents. The study included 2066 women (53.3%) and 1812 men (46.7%). Average age was 48.89 ±â€Š17.48 years. Most participants resided in urban areas (2956 people, 76.2%), whereas 922 resided in rural areas (23.8%). RESULTS:: The prevalence of AH in Serbia is 42.7%. Hypertension is more frequently diagnosed among women (53.3%), than among men (46.7%). One thousand, four hundred and twelve respondents were previously diagnosed and treated for hypertension. The estimated awareness of the presence of AH was 42.99% (i.e. 40.00% among male and 45.41% among female participants). Out of all diagnosed cases of hypertension, 390 persons (27.7%) have well regulated blood pressure values, whereas 1022 persons (72.3%) do not have their blood pressure under control. CONCLUSION:: Serbia belongs to countries with a high prevalence of AH. A poor control of AH may be explained in view of socioeconomic problems. High prevalence of AH may indicate a remarkably high cardiovascular disease mortality in Serbia. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.


Jovanovic D.,Institute of Public Health of Serbia Dr Milan Jovanovic Batut | Rasic-Milutinovic Z.,University of Belgrade | Paunovic K.,Institute of Hygiene and Medical Ecology | Jakovljevic B.,Institute of Hygiene and Medical Ecology | And 2 more authors.
International Journal of Hygiene and Environmental Health | Year: 2013

Arsenic in drinking water presents a serious public health problem in Serbia, but its relationship with diabetes has not been studied previously. The aim of this study was to explore the association between exposure to arsenic in drinking water and the occurrence of type 2 diabetes in Middle Banat region, Serbia. This cross-sectional study comprised two populations. Exposed population in Middle Banat region consumes drinking water with arsenic (mean = 56. μg/L); unexposed population from six regions in Central Serbia consumes arsenic below detection limit (2. μg/L). Newly diagnosed cases of type 2 diabetes were obtained from the National Registry of Diabetes in 2008. The Registry included age, gender, family history of diabetes, presence of overweight, central obesity, cholesterol and triglyceride levels. In addition, the number of cases of diabetes reported in years 2006, 2007 and 2009 was used to calculate standardized incidence rates for both populations. Two populations were comparable by age, family history of diabetes and prevalence of overweight persons. Unexposed population was more likely to have central obesity, and high total cholesterol and triglycerides. Standardized incidence rates of type 2 diabetes were higher in exposed population. Odds ratios for type 2 diabetes were significantly higher for the exposed population, both men and women, in the period from 2006 to 2009, when compared with the unexposed population. The population from Middle Banat region, consuming drinking water with low levels of arsenic, was at higher risk for the occurrence of type 2 diabetes in comparison to the unexposed population in Central Serbia. © 2012 Elsevier GmbH.


Opacic D.,Military Medical Academy | Lepsanovic Z.,Military Medical Academy | Sbutega-Milosevic G.,Institute of Hygiene and Medical Ecology
Archives of Biological Sciences | Year: 2013

A wide variety of antimicrobial cationic agents, such as chlorhexidine gluconate, are commonly used in antiseptic preparations in the prevention of nosocomial infections caused by methicillin-resistant Staphylococcus aureus (MRSA). In this study was investigated the activity of chlorhexidine gluconate against MRSA and methicillin-sensitive Staphylococcus aureus (MSSA). The quantitative suspension test was carried out with 1% and 4% chlorhexidine gluconate and contact time of 30 s, 60 s and 120 s. Since the plasmid-borne gene qacA/B confers resistance to cationic antiseptic agents in S. aureus, activity was also examined with regard to the presence of qacA/B. The results indicate that neither 1% nor 4% chlorhexidine gluconate achieved a log10 reduction factors (RF) >5 against MRSA and MSSA strains at 30 s, 60 s and 120 s. At all concentrations, the RF for MRSA qacA/B negative strains were significantly higher when compared to MRSA qacA/B positive strains at 60 s and 120 s.


Knezevic T.,Institute Of Public Health Of Serbia Dr Milan Jovanovic Batut | Dragana Jovanovic C.D.,Institute Of Public Health Of Serbia Dr Milan Jovanovic Batut | Jakovljevic B.,Institute of Hygiene and Medical Ecology
One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment | Year: 2014

Vojvodina, a northern region of Serbia, belongs to the Pannonian Basin, whose aquifers contain high concentrations of arsenic. This study represents arsenic levels in drinking water in ten municipalities in Vojvodina, Serbia. Around 63% of all water samples exceeded Serbian and European standards for arsenic in drink water. Large variations in arsenic were observed among supply systems. © 2014 Taylor & Francis Group.


Davidovic D.B.,Institute of Hygiene and Medical Ecology
Acta chirurgica Iugoslavica | Year: 2011

Gallstone formation is a multifactorial disease, caused by the interaction of genetic and enviromental factors. In order to prevent gallbladder stone disease, it is useful to detect modifable risk factors, which contribute to its development. The aim of this study is to analyze the potential relationship between nutrition and the development of gallstone disease, and to establish the possibility for its prevention. The study examined 114 patients; 55 of them suffered from gallstone disease, while 59 were healthy controls who were age- and sex- matched. Diagnosis of gallbladder stone disease was made by ultrasonography. Diet was established using a 24-hour dietary recall method. In the multivariate model, high energy intake (OR = 9.720, p < 0.001) and overnight fasting period (12 hours and longer) (OR = 4.285, p = 0.005) were the most important predictors of gallstone disease, after adjustment for Body Mass Index. These factors can be altered in order to prevent gallstone disease.


PubMed | Institute of Hygiene and Medical Ecology
Type: Journal Article | Journal: Acta chirurgica Iugoslavica | Year: 2012

Gallstone formation is a multifactorial disease, caused by the interaction of genetic and enviromental factors. In order to prevent gallbladder stone disease, it is useful to detect modifable risk factors, which contribute to its development. The aim of this study is to analyze the potential relationship between nutrition and the development of gallstone disease, and to establish the possibility for its prevention. The study examined 114 patients; 55 of them suffered from gallstone disease, while 59 were healthy controls who were age- and sex- matched. Diagnosis of gallbladder stone disease was made by ultrasonography. Diet was established using a 24-hour dietary recall method. In the multivariate model, high energy intake (OR = 9.720, p < 0.001) and overnight fasting period (12 hours and longer) (OR = 4.285, p = 0.005) were the most important predictors of gallstone disease, after adjustment for Body Mass Index. These factors can be altered in order to prevent gallstone disease.

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