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Satyanarayana V.A.,University of Washington | Vaddiparti K.,Institute of Human Behavior and Allied science IHBAS | Chandra P.S.,National Institute of Mental Health and Neuro Sciences | O'Leary C.C.,University of Washington | And 2 more authors.
Drug and Alcohol Review | Year: 2010

Introduction and Aims. This study compared the husband's report and wife's report of her husband's problem drinking, among residents of an urban slum in Bangalore, India. Design and Methods. The data come from a feasibility study to prevent HIV infection among at-risk women in Bangalore. Household enumeration was carried out (n = 509) to choose 100 married men between 18 and 50 years who reported problem drinking (scores 8 and above) on the Alcohol Use Disorder Identification Test (AUDIT). Wives of these married men, considered to be at risk for HIV because of their husband's hazardous drinking, were subsequently recruited for the study (n = 100). Written informed consent was obtained; wives were asked about the drinking history of their husbands through the AUDIT-WR (Wife's Report) developed for the present study. Results. Prevalence of problem drinking in the enumerated sample (n = 509) was high (n = 186;37%). The husband's report and his wife's report of his problem drinking was concordant (r = 0.57-0.75) on eight out of 10 items, and the total AUDIT score. Discussion and Conclusions. The AUDIT-WR is a reliable and culturally relevant measure of husband's problem drinking. In India, men with problem drinking are hard to reach. Therefore, proxy report of the wife may be useful when the husband is either unavailable or uncooperative for assessment. © 2010 Australasian Professional Society on Alcohol and other Drugs. Source

Bansal S.,Institute of Human Behavior and Allied science IHBAS | Gupta S.K.,Institute of Human Behavior and Allied science IHBAS | Kar S.K.,University of Lucknow | Singh P.,Institute of Human Behavior and Allied science IHBAS | And 2 more authors.
Journal of Indian Association for Child and Adolescent Mental Health | Year: 2015

Obsessive compulsive disorder (OCD) is a psychiatric disorder of heterogeneous phenomenology and its onset follows a bimodal pattern. The onset of OCD can be very early or late. The clinical presentation, co-morbidities as well as treatment outcomes are affected by the age of onset of obsessive compulsive disorder. The most accepted explanatory model to explain OCD is bio-psycho-social model, which explains the interplay of biological, psychological as well as social factors in the causation of OCD. In this case report, a rare case of very early onset OCD in an adolescent boy with co-morbid agoraphobia where the onset of OCD was as early as infancy is being discussed. © 2015 Indian Association for Child and Adolescent Mental Health.All rights reserved. Source

Jha S.,Institute of Human Behavior and Allied science IHBAS | Garg A.,Institute of Human Behavior and Allied science IHBAS
Psychiatry Research | Year: 2016

The coincidence or causal incidence of hormonal dysregulation leading to psychotic manifestation had been a point of debate. The interplay of these hormones in pathogenesis of psychotic symptom domains is still inconclusive along with some symptom domains which worsen with antipsychotics. Early detection and treatment with liaison approach is of great help to such patients. We report a case of schizophrenia with primary hypogonadism that responded dramatically to add on testosterone supplement. © 2016 Elsevier Ireland Ltd. Source

Gupta A.,Institute of Human Behavior and Allied science IHBAS | Gupta C.,Institute of Human Behavior and Allied science IHBAS
Asian Journal of Transfusion Science | Year: 2016

Context: Certain quality indicators are mandatory in the maintenance and improvement of quality in blood transfusion. Monitoring of such indicators should be done regularly and deficiencies are to be corrected for effective blood transfusion services. Aims: To study the usefulness of monitoring of the National Accreditation Board for Hospitals and Healthcare Providers (NABH) core indicators in blood transfusion and in the maintenance of hemovigilance. Settings and Design: Hemovigilance is a quality process to improve quality and increase the safety of blood transfusion. It covers and surveys all activities of the blood transfusion chain from donors to recipients. Core indicators' monitoring is a part of the hemovigilance process. Materials and Methods: A 2-year retrospective study was conducted in a blood storage unit of a NABH accredited tertiary care hospital of a metropolitan city. Four NABH core indicators in blood transfusion were observed and monitored by the clinical and blood storage unit staff of different levels. Results: It was observed that there was an improvement in quality by core indicators monitoring with decreased wastage of blood and blood components, decreased average turnaround time for issue of blood and blood components, and lesser number of transfusion reactions. Conclusion: This study demonstrated that monitoring of NABH core indicators results in the enhancement of quality and safety in blood transfusion services, reducing the incidence of transfusion reactions. © 2016 Asian Journal of Transfusion Science-Published by Wolters Kluwer - Medknow. Source

Grover S.,CSIR - Central Electrochemical Research Institute | Talwar P.,CSIR - Central Electrochemical Research Institute | Baghel R.,CSIR - Central Electrochemical Research Institute | Kaur H.,CSIR - Central Electrochemical Research Institute | And 5 more authors.
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics | Year: 2010

Variability in the physiological levels of neuroactive estrogens is widely believed to play a role in predisposition to several disorders of the central nervous system. Local biosynthesis of estrogens in the brain as well as their circulating serum levels are known to contribute to this pool of neuroactive steroids. It has been well accepted that estrogens modulate neuronal functions by affecting genesis, differentiation, excitability, and degeneration of nerve cells. These actions of estrogens appear to be more prominent in females with higher concentrations and marked variability of circulating serum levels occurring over a woman's lifetime. However, our knowledge regarding the variability of neuroactive steroid levels is very limited. Furthermore, several studies have recently reported differences in the synchronization of circulating and neuronal levels of estradiol. In the absence of reliable circulating steroid levels, knowledge of genetic variability in estrogen disposition may play a determining factor in predicting altered susceptibility or severity of neuropsychiatric disorders in women. Over the past decade, several genetic variants have been linked to both differential serum estrogen levels and predisposition to diverse types of neuropsychiatric disorders in women. Polymorphisms in genes encoding estrogen-metabolizing enzymes as well as estrogen receptors may account for this phenotypic variability. In this review, we attempt to show the contribution of genetics in determining estrogenicity in females with a particular emphasis on the central nervous system. This knowledge will further provide a driving force for unearthing the novel field of "Estrogen Pharmacogenomics.© 2010 Wiley-Liss, Inc. Source

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