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Akhter M.S.,All India Institute of Medical Sciences | Biswas A.,Institute of Experimental Hematology and Transfusion Medicine | Ranjan R.,All India Institute of Medical Sciences | Sharma A.,All India Institute of Medical Sciences | And 2 more authors.
Clinica Chimica Acta

Background: Endothelium derived nitric oxide is formed from l-arginine by endothelial nitric oxide synthase encoded by the nitric oxide synthase 3 (NOS3) gene. Nitric oxide possesses a variety of protective effects on endothelial cells and therefore NOS3 is a logical candidate gene to be investigated for the susceptibility of deep vein thrombosis (DVT). Methods: One hundred consecutive patients (M: F=56:44) with idiopathic deep vein thrombosis and an equal number of age and sex matched healthy controls were the study subjects. All study subjects were typed for five NOS3 polymorphisms (-786C/T, -922A/G, 894G/T, Intron 4 VNTR, and Intron 23 G10T). Results: Two polymorphisms (-922A/G and 894G/T) are showing their association with DVT.-922A/G shows both genotypic (P=0.0218; χ2=5.25; O.R=1.94) as well as allelic association (P=0.0014; χ2=10.19; O.R=2.0) while 894G/T shows only allelic (P=0.04; χ2=3.93; O.R=3.93) association with DVT. Conclusion: Susceptibility to DVT in North Indian Asian patients may be associated with some variants of NOS3 gene. © 2010 Elsevier B.V. Source

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