Institute of Heavy Organic Synthesis ICSO Blachownia

Poland

Institute of Heavy Organic Synthesis ICSO Blachownia

Poland
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Nachajski M.J.,Medical University of Lódz | Piotrowska J.B.,University of Lodz | Kolodziejczyk M.K.,Medical University of Lódz | Lukosek M.,Institute of Heavy Organic Synthesis ICSO Blachownia | Zgoda M.M.,Medical University of Lódz
Acta Poloniae Pharmaceutica - Drug Research | Year: 2013

Research was conducted into the solubilization processes of diclofenac, ibuprofen, ketoprofen and naproxen in equilibrium conditions in the environment of aqueous solutions of oxyethylated lardis fractions (Adeps suillus, Polish Pharmacopoeia VIII). The determined thermodynamic (cmc, δG m 0 ) and hydrodynamic (R0, Robs, Ω, Mη) parameters characterizing the micelle of the solubilizer and the adduct demonstrate that lipophilic therapeutic agents are adsorbed in a palisade structure of the micelle due to a topologically created so-called ilipophilic adsorption pocketi. This shows that the hydrophilicity of the micelle and the adsorption layer decreases at the phase boundary , which is confirmed by the calculated values of coefficients Am and r .A. The results obtained indicate the possibility of making use of the class of non-ionic surfactants which are not ksenobiotics for the modification of the profile of solid oral dosage forms with lipophilic therapeutic agents from the II class of Biopharmaceutics Classification System (BCS).


Pezoa-Conte R.,Åbo Akademi University | Leyton A.,University of Chile | Anugwom I.,Umeå University | von Schoultz S.,Åbo Akademi University | And 8 more authors.
Algal Research | Year: 2015

Algae are known to grow at high rates compared to terrestrial plants that contain comparable amounts of carbohydrates by weight. Therefore, this renders them attractive in terms of any biorefinery concept. In this work the green alga Ulva rigida, containing 40wt.% of carbohydrates was pretreated with a switchable ionic liquid (SIL), distillable ionic liquid (DIL) and low-viscosity ionic liquid (LVIL). The SIL DBU-MEA-SO2 was prepared from a mixture of mono-ethanolamine (MEA) and 1,8-diazabicyclo-[5,4,0]-undec-7-ene (DBU) that was coupled with sulfur dioxide (SO2), whereas the DIL [TMGH+][EtCO2 -] (1,1,3,3-tetramethylguanidine propionate) was synthesized by a simple acid-base neutralization reaction. Consequently, the LVIL [HDBU+][5OF-] protonated 1,8-diazabicyclo-[5,4,0]-undec-7-ene- 2,2,3,3,4,4,5,5-octafluoro-1-pentoxide was used as received. The treatments were carried out in the temperature range of 100-160°C for 6h. The products obtained after the treatments were analyzed using different techniques like ICP, OES, SEM, TEM, TGA, FTIR and carbohydrate determination by GC. Upon treatment with DIL up to 67wt.% of carbohydrates could be dissolved. For the first time, processing of U. rigida was carried out in ionic liquids so that the mass balance of the process was obtained. It can be concluded that 1,1,3,3-tetramethylguanidine propionate shows significant potential when aiming at releasing carbohydrates from algal biomass that, consequently, can be applied in the production of platform chemicals and/or biofuels such as bioethanol. © 2015 Elsevier B.V.

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