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Suwałki, Poland

Grajek Z.W.,Institute of Health Care | Dadan J.,Medical University of Bialystok | Ladny J.R.,Medical University of Bialystok | Opolski M.,Regional Hospital
Advances in Clinical and Experimental Medicine | Year: 2015

Background: The need to obtain successful surgical hemostasis had a significant impact on the development of electrosurgery. Innovative technical solutions necessitate the continuous training of surgeons in the use of more modern technologies. The diversity of solutions is also associated with the need to adapt the methods for obtaining hemostasis to the type of operation. Each time, the introduction of new technologies requires a critical evaluation of the results of surgical treatment. The most important measure of quality in thyroid surgery is the presence of chronic complications, such as the recurrent laryngeal nerve palsy and parathyroid insufficiency. Transient disorders also have a significant impact on the patient's comfort and quality of life. The report is preliminary in nature and it requires further investigation. Objectives: The aim of the study was to evaluate the effect of three methods for obtaining hemostasis on the occurrence of hypoparathyroidism, recurrent laryngeal nerve palsy, bleeding and the surgical site infection after thyroid surgery. Material and Methods: A retrospective analysis included patients who underwent thyroidectomy (n = 654). Three methods of hemostasis were used. The first group (n = 339) had blood vessels tied off. In the second (n = 192) bipolar electrocoagulation was used and in the third one (n = 123) bipolar electrocoagulation with integrated cutting mechanism. Results: The transient hypoparathyroidism was found in 1.4% patients in the first group, 8.3% in the second and 27.6% in the third one. Chronic hypoparathyroidism was found in 0.29% in the first group, 0% in the second group and 2.4% in the third group. Significantly statistical differences were found in the incidence of transient hypoparathyroidism. Conclusions: Significant statistical differences were found in incidences of transient hypoparthyroidism in the group where bipolar electrosurgery was used. © Copyright by Wroclaw Medical University.


Maciejczyk M.,Medical University of Bialystok | Pietrzykowska A.,Medical University of Bialystok | Zalewska A.,Medical University of Bialystok | Knas M.,Institute of Health Care | Daniszewska I.,Specialist Dental Practice
Advances in Clinical and Experimental Medicine | Year: 2016

Matrix metalloproteinases (MMPs) belong to a family of structurally related zinc-dependent proteolytic enzymes that are known to play a key role in the catabolic turnover of extracellular matrix (ECM) components. Research studies to date have indicated that MMPs regulate the activity of several non-ECM bioactive substrates, including growth factors, cytokines, chemokines and cell receptors, which determine the tissue microenvironment. Disruption of the balance between the concentration of active matalloproteinases and their inhibitors (TIMPs) may lead to pathological changes associated with uncontrolled ECM turnover, tissue remodeling, inflammatory response, cell growth and migration. This brief review presents some information on MMPs' role in inflammatory, metabolic and cancer abnormalities related to the salivary glands, as well as MMP-related aspects that lead to the formation of human dentinal caries lesions. In oral diseases, the most relevant biological fluid commonly used for diagnosing periodontal diseases is saliva. In diseased patients with significantly higher levels of MMPs in their saliva than healthy people, most extracellular matrix components undergo digestion to lower molecular weight forms. Conventional treatment successfully reduces the levels of MMPs inhibits the progressive breakdown of gingival and periodontal ligament collagens. Beside inflammatory abnormalities like Sjögren's syndrome (SS), a large group of disorders is comprised of cancers, most of them involving the parotid gland. © Copyright by Wroclaw Medical University.


Kim T.-W.,Soonchunhyang University | Kim T.-W.,Institute of Health Care | Lee J.-B.,Soonchunhyang University
Applied Biochemistry and Biotechnology | Year: 2013

We assessed the effects of ingesting caffeine before passive heat loading (PHL) on serum leptin and sweating response, which are both physiological responses associated with energy expenditure. The subjects were nine male university students (age, 24.1 ± 3.5 years; height, 173.4 ± 7.6 cm; weight, 69.2 ± 5.7 kg; maximal oxygen consumption, 48.6 ± 4.7 ml × kg-1 × min-1). This study used a within-subject, random, crossover design. Tests were performed twice at the same time (2-5 p.m.) at a 1-week interval following 3 mg×kg-1 caffeine ingestion (Caff-I) or not (No-Caff). PHL included a half bath in hot water (42 ± 0.5 C for 30 min) in a thermoneutral climate chamber (25 ± 0.5 C, 60 ± 3 % relative humidity, <1 m/s air velocity). After PHL, blood levels of leptin and free fatty acids were significantly higher in the Caff-I compared to those in the No-Caff after PHL (P < 0.01). Waist circumference and whole-body sweat loss volume were significantly higher in the Caff-I compared to those in the No-Caff (P < 0.001). Mean active sweat gland density was significantly higher in the Caff-I compared to those in the No-Caff at 10 min during PHL (P < 0.001). The results suggest that ingesting caffeine before PHL is more energy efficient than that of a single PHL. © 2013 Springer Science+Business Media New York.


Kleszczewski T.,Medical University of Bialystok | Kleszczewska E.,Institute of Health Care | Buzun L.,Medical University of Bialystok | Modzelewska B.,Medical University of Bialystok
Journal of Trace Elements in Medicine and Biology | Year: 2016

Background: The aim of this study was the simultaneous determination of levels of cadmium and l-ascorbic Acid (AA) in human saphenous vein (SV) used in coronary artery bypass grafting (CABG) and check whether there is a relationship between these levels. Methods: Human SV were collected from 40 patients (20 men and 20 women; age, 40-75 years) at the time of routine coronary artery surgical revascularization. The concentration of cadmium in the tissue was determined according to the GF AAS-atomic absorption method. The concentration of AA was assayed in supernatant by FIA method with spectrophotometric detection. Results: AA concentration (mean ± SD); men: 98,7 ± 13,18 μg/g tissue, women: 96,06 ± 11,98 μg/g tissue. Cadmium concentration(mean ± SD); men: 309 ± 103,71 ng/g tissue, women: 348,5 ± 255,71 ng/g tissue. Correlations among concentrations of AA and cadmium were insignificant negative in the group of men (Pearson r = -0,1504, p = 0,5269) and in the group women (Pearson r = -0339, p = 0144). Conclusions: Negative correlations among concentrations of AA and cadmium in human SV obtained in our study may indicate a protective effect of this vitamin in relation to toxic cadmium. © 2016 Elsevier GmbH.


Grandys M.,University School of Physical Education in Cracow | Majerczak J.,University School of Physical Education in Cracow | Kulpa J.,Cancer Institute | Duda K.,Institute of Health Care | And 2 more authors.
Physiological Research | Year: 2016

Acute exercise-induced changes in cortisol concentration (C) and training related adaptation within hypothalamic-pituitary-adrenal (HPA) axis has been widely examined, but their influence on muscle strength performance is at best uncertain. Twenty four young healthy men were randomly assigned to an endurance training group (ET, n=12) or to a non-exercising controls (CON, n=12). ET performed supervised endurance training on cycle ergometer for 20 weeks. Endurance training program improved exercise capacity (14 % increase in power output generated at peak oxygen uptake - VO2peak), muscle strength performance (increase in MVC - maximal voluntary contraction - by 9 % and in TTF 50 % MVC - time to fatigue at 50 % MVC - by 21 %) and led to a decrease in basal serum C concentration (P=0.006) and an increase in basal testosterone to cortisol (T/C) and free testosterone to cortisol (fT/C) ratios (P=0.01 and P=0.02, respectively). It was found that the decrease in C concentration (ΔC) was positively correlated to the increase in local muscular endurance (ΔTTF 50 % MVC). No significant hormonal changes were seen in CON group. It is concluded that greater decrease in cortisol concentration after the endurance training is accompanied by poorer improvement in skeletal muscle performance in previously untrained subjects. © 2016 Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.

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