Ayuso M.I.,Hospital Ramon y Cajal |
Chioua M.,Institute of Organic Chemistry CSIC |
Martinez-Alonso E.,Hospital Ramon y Cajal |
Soriano E.,Institute of Organic Chemistry General CSIC |
And 5 more authors.
Journal of Medicinal Chemistry | Year: 2015
This study describes CholesteroNitrone 2 as an antioxidant and neuroprotective agent against ischemic injury. Neuroprotection was assessed using in vitro and in vivo experimental ischemia models. The compound significantly increased cell viability, induced neuroprotection following ischemic reperfusion, and decreased neurological deficit scores in treated animals, supporting the next preclinical studies as a potential agent for the treatment of stroke. (Figure Presented). © 2015 American Chemical Society.