Okorokov P.L.,Institute of General and Clinical Pathology |
Anychovskaya I.A.,Institute of General and Clinical Pathology |
Yakovleva M.M.,Institute of General and Clinical Pathology |
Lazareva S.I.,Moscow State University |
And 5 more authors.
Human Physiology | Year: 2012
Integral parameters of bacterial lipopolysaccharide concentration and antiendotoxin immunity activity were determined in the blood serum of subjects with two extreme variants of eating disorders: obesity and anorexia nervosa (in its clinical model, long-term starvation). The results of the study showed that obese patients had initially higher endotoxin concentrations (2. 41 ± 0. 11 vs 1. 13 ± 0. 05 EU/mL in the control), which significantly decreased as a result taking a course of orlistat or after starvation (for no longer than 20 days) (to 1. 34 ± 0. 04 and 1. 01 ± 0. 09 EU/mL, respectively). The decrease in the endotoxin serum level was associated with an increase in the concentration of high-density lipoproteins (HDLs) and a decrease in the concentration of low-density lipoproteins (LDLs). This allowed us to assume that the complex of the latter with the endotoxin is the LDL fraction that may function as a depot of the hydrophobic form of the lipopolysaccharide molecule in the bloodstream. Long-term starvation (starting from day 20) led to the appearance of symptoms characteristic of septic states, which was preceded by a twofold increase in the concentration of the endotoxin and antibodies against the enterobacterial common antigen and subsequent increase in the level of anti-glycolipid antibodies (from 133. 2 ± 2. 6 to 355. 6 ± 15. 0 optical density arbitrary units) starting from day 25-27 of starvation, which is characteristic for the initial phase of the systemic inflammatory response syndrome. © 2012 Pleiades Publishing, Ltd.