Institute of Foreign Trade and Management IFTM

Morādābād, India

Institute of Foreign Trade and Management IFTM

Morādābād, India
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Singh D.P.,Institute Of Foreign Trade And Management Iftm | Hashim S.R.,Institute Of Foreign Trade And Management Iftm | Singhal R.G.,Shobhit University
International Journal of Drug Development and Research | Year: 2010

A series of thioether derivatives of 2-Chloro-3-methylquinoxaline have been synthesized by reacting 3-methylquinoxalin-2-thiosodium with 2-chloro-N-(substituted aryl/alkyl)-acetamides. The synthesis was initiated with the reaction of o-phenylenediamine (1) with ethyl pyruvate in n-butanol to yield 2-hydroxy-3-methyl quinoxaline (2), which on treatment with POCl 3, yielded 2-chloro-3-methylquinoxaline(3). A mixture of the compound(3) and sodium sulphide in DMF was refluxed to yield 3-methylquinoxalin-2-thiosodium(4),which on treatment with different Nsubstituted chloroacetamides afforded the one pot synthesis of 2-(2-methylquinoxalin-3-ylthio)-N-substitutedaryl/alkyl)-acetamides(5a-k). 2-chloro-N-substituted acetamides were prepared by treating substituted anilines in glacial acetic acid with chloroacetylchloride, warming on the water bath for half an hour and then precipitating, 2-chloro-N-substituted acetamides by addition of saturated aqueous solution of anhydrous sodium acetate. A compound 2-(benzylthio)-3-methylquinoxaline 5l was also prepared. The newly synthesized compounds have been characterized by IR, and 1HNMR spectra, analysis. All compounds (5a-l) were screened for their in vivo anti inflammatory activity by carrageenan induced rat paw edema method. Compounds 5a, 5b, 5d, 5e, 5g and 5k have been found to possess good anti inflammatory activity.


Pal D.,Institute of Foreign Trade and Management IFTM | Mitra S.,Seemanta Institute of Pharmaceutical science
Journal of Advanced Pharmaceutical Technology and Research | Year: 2010

The in vitro antioxidant activity of stems of Opuntia vulgaris Mill had been investigated by estimating degree of non-enzymatic haemoglobin glycosylation measured colorimetrically at 520 urn. It was found that benzene and chloroform extract of O. vulgaris had better antioxidant activity than petroleum ether, ethyl acetate, ethanol and aqueous extract. The antioxidant activity of the extracts was concentration dependent and comparable to that of D -α-tocopherol (vitamin E) and ascorbic acid (vitamin C), standard antioxidant compounds used. © JAPTR, All Rights Reserved.


Deshwal V.K.,Doon PG Paramedical College | Agarwal S.,Institute of Foreign Trade and Management IFTM | Ahmad Z.,Teerthankar Mahaveer Dental College and Research Center
Journal of Pure and Applied Microbiology | Year: 2011

Coagulase Negative Staphylococcus (CNS) strains were isolated from hospital personnel and hospital environment. Total 320 samples were taken from skin, anterior nares, nails, finger tips, stethoscope, floor, door handle and catheter. Samples were spread on Mannitol Salt agar Medium and one Staphylococcus culture from each sample was select for further study. Isolated CNS strains were characterized according to Bergey's manual of determinative bacteriology. Results suggested that five types of CNS strains-Staphylococcus saprophyticus, Staphylococcus epidermidis, Staphylococcus hominis, Staphylococcus haemolyticus, Staphylococcus sp. were isolated from hospital personnel and hospital environment and 24.68% strains were Coagulase negative staphylococcus (CNS). Maximum (CNS) strains were present in anterior nares and it was 42.5%. CNS was also present in skin (22.5%), nails (30%), finger tip (27.5), stethoscope (27.5), floor (15%), door handle (20%) and catheter (12.5).


Yadav E.,Institute of Foreign Trade and Management IFTM | Sachan N.,Institute of Foreign Trade and Management IFTM
Pharmacognosy Reviews | Year: 2012

From the centuries, herbal medicines are used to treat various diseases and now they had become an item of global importance, with both medicinal and economic implications. The demand of herbal medicine is being increasing day by day due to their safety and efficacy. Now herbals had taken over the allopathic system due to their less side effect and efficient working mechanism. Herbals are playing and pivotal role in increasing the economy of the country and had taken the nation on to the new path to achieve the goal of development. Lygodium flexuosum (Linn) Sw. is a fern found nearly throughout India up to an elevation of 1500 meter. It belongs to the family Lygodiaceae and widely used in treating various ailments like jaundice, dysmenorrhea, wound healing and eczema. It is the rich source of alkaloids, flavonoids, saponins and cumarin. The main constitute of the plant is lygodinolide which is mainly used in wound healing. In the present review an attempt had been made to explore different aspects of L. flexuosum.


PubMed | Institute of Foreign Trade and Management IFTM
Type: Journal Article | Journal: Journal of advanced pharmaceutical technology & research | Year: 2012

The in vitro antioxidant activity of stems of Opuntia vulgaris Mill had been investigated by estimating degree of non-enzymatic haemoglobin glycosylation measured colorimetrically at 520 urn. It was found that benzene and chloroform extract of O. vulgaris had better antioxidant activity than petroleum ether, ethyl acetate, ethanol and aqueous extract. The antioxidant activity of the extracts was concentration dependent and comparable to that of D-- tocopherol (vitamin E) and ascorbic acid (vitamin C), standard antioxidant compounds used.

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