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Mazumder U.K.,Jadavpur University | Mondal A.,Jadavpur University | Pal D.,Institute of Foreign Trade and Management | Mishra S.L.,JKK Nataraja Dental College and Hospital
Natural Product Communications | Year: 2010

Flavonoids obtained from Enhydra fluctuans (FEF) were screened for anticancer activity against Ehrlich's ascites carcinoma (EAC) bearing Swiss albino mice. The anticancer activity was assessed by measuring the tumor growth response, percentage increase of life span, hematological parameters, lipid peroxidation, and antioxidant enzyme activity, like GSH and CAT. Two flavonoids, baicalein 7-O-glucoside and baicalein 7-O-diglucoside, were isolated from the ethyl acetate fraction. Treatment with FEF caused a significant decrease in the tumor cell volume and increase of life span. All the hematological parameters, malonaldehyde content and antioxidant enzyme activity were restored towards the normal level. FEF was found to be cytotoxic in the in-vitro model.


Verma C.,Institute of Foreign Trade and Management | Nanda S.,P.A. College | Singh R.K.,Uttarakhand Technical University | Singh R.B.,Halberg Hospital and Research Center | And 2 more authors.
Open Nutraceuticals Journal | Year: 2011

Biotechnology offers a variety of potential benefits and risks. It has enhanced food production by making plants less vulnerable to drought, frost, insects, and viruses and by enabling plants to compete more effectively against weeds for soil nutrients. In a few cases, it has also improved the quality and nutrition of foods by altering their composition. However, the use of biotechnology has also raised concerns about its potential risks to the environment and people. For example, some people fear that common plant pests could develop resistance to the introduced pesticides in GM crops that were supposed to combat them. Genetic engineering provides a means to introduce genes into plants via mechanisms that are different in some respects from classical breeding. A number of commercialized, genetically engineered (GE) varieties, most notably canola, cotton, maize and soybean, were created using this technology, and at present the traits introduced are herbicide and/or pest tolerance. Gene technology enables the increase of production in plants, as well as the rise of resistance to pests, viruses, frost, etc. Gene transfer is used to modify the physical and chemical composition and nutritional value of food. Gene transfer in animals will play a part in boundless possibilities of improving qualitative and quantitative traits. The yield, carcass composition and meat characteristics the use of nutritive substances? not sure what is being said here?, and resistance to diseases can be improved. On the other hand, negative effects of gene technology on animals, human, and environment should be considered. The present review article is the compilation of various studies that present both positive and negative impacts of genetically modified food on human health. © Verma et al.; Licensee Bentham Open.


Bala V.,Central Drug Research Institute | Bala V.,Institute of Foreign Trade and Management | Chhonker Y.S.,Central Drug Research Institute | Hashim S.R.,Central Drug Research Institute | Hashim S.R.,Institute of Foreign Trade and Management
Asian Journal of Chemistry | Year: 2010

A series of seven Schiff bases were synthesized by reacting 2-formylphenoxy acetic acid with aromatic amines. The chemical structures of these compounds were confirmed by means of IR and 1H NMR. The compounds were assayed by the disc diffusion method for antibacterial activity against Staphylococcus aureus and Escherichia coli. Among the compounds tested, V1, V3, V4 and V6, exhibited good antibacterial activity, almost equal to that of ampicillin used as standard drug.


Singh D.C.P.,Institute of Foreign Trade and Management | Hashim S.R.,Institute of Foreign Trade and Management | Singhal R.G.,Shobhit University
E-Journal of Chemistry | Year: 2011

2-Chloro-3-methylquinoxaline was selected as nucleus around which the molecular manipulations were carried out to get new compounds expected to possess better anti microbial activity. Various quinoxaline derivatives have been synthesized by replacing the chlorine at C-2 with a thioether linkage, which in turn attached to 2-(N-(substituted phenyl)acetamides. The synthesized compounds (5) were tested for their antimicrobial activity. Compounds 5b, 5c, 5d and 5i were found most active (comparable to the standard antibacterial Ciprofloxacin) amongst them. The structure of the compounds was confirmed on the basis of their spectral data.


Banerjee S.,Institute of Foreign Trade and Management | Chaurasia G.,Institute of Foreign Trade and Management | Ghosh A.,Birla Institute of Technology
Asian Journal of Pharmaceutical and Clinical Research | Year: 2010

Polymer scientists have been trying to mimic this behaviour for the last twenty years creating the so called smart polymers. Smart polymeric materials respond with a considerable change in their properties to small changes in their environment. Environmental stimuli include salt, UVirradiation, temperature, pH or concentration, chemicals, light, magnetic or electric field, ionic factors, biological molecules, solvent exchange etc. This behaviour can be utilised for the preparation of so-called 'smart' drug delivery systems, which mimic biological response behaviour to a certain extent. These smart polymeric systems have several advantages over conventional methods, such as ease of manufacturing, ease of administration, biodegradability and the ability to alter release profiles of the incorporated agents. The possible environmental conditions to use for this purpose are limited due to the biomedical setting of drug delivery as application. Different organs, tissues and cellular compartments may have large differences in pH, which makes the pH a suitable stimulus. "Smart" stimuli responsive polymeric materials can be either synthetic or natural, which imparts very promising applications in the biomedical field as delivery systems of therapeutic agents, tissue engineering, cell culture supports, gene carrier, textile engineering, radioactive wastage, protein purification and oil recovery. This chapter is focused on the entire features of smart polymers and their most recent and relevant applications as biomaterials in drug delivery, tissue engineering, etc. Then selected examples of applications are described.

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