China Institute of Food and Nutrition Development

Beijing, China

China Institute of Food and Nutrition Development

Beijing, China
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Tong L.-T.,Chinese Academy of Agricultural Sciences | Guo L.,Chinese Academy of Agricultural Sciences | Zhou X.,Chinese Academy of Agricultural Sciences | Qiu J.,China Institute of Food and Nutrition Development | And 3 more authors.
Journal of the Science of Food and Agriculture | Year: 2016

BACKGROUND: The aim of present study was to investigate the hypocholesterolaemic effects of oat proteins (OP) in hamsters fed with a hypercholesterolaemic diet. The hamsters were divided into five groups and fed with the experimental diets containing oat, OP, oat β-glucan (OG), or OP+OG for 30 days. RESULTS: OP and the OG significantly lowered the concentrations of plasma low-density lipoprotein-cholesterol and liver total cholesterol (TC), and increased the excretion of faecal bile acid and TC. Plasma and liver TC in the OP+OG group were significantly lower than those in the OP or OG groups. Both OP and OG increased the activity of liver cholesterol 7α-hydroxylase (CYP7A1), while its activity in the OP+OG group was strongly increased compared with the OP or OG groups. CONCLUSION: These results indicated that dietary OP could improve hypercholesterolaemia, while dietary OP and OG together would have better hypocholesterolaemic effects. © 2015 Society of Chemical Industry.


PubMed | China Institute of Food and Nutrition Development and Chinese Academy of Agricultural Sciences
Type: Journal Article | Journal: Journal of the science of food and agriculture | Year: 2016

The aim of present study was to investigate the hypocholesterolaemic effects of oat proteins (OP) in hamsters fed with a hypercholesterolaemic diet. The hamsters were divided into five groups and fed with the experimental diets containing oat, OP, oat -glucan (OG), or OP+OG for 30 days.OP and the OG significantly lowered the concentrations of plasma low-density lipoprotein-cholesterol and liver total cholesterol (TC), and increased the excretion of faecal bile acid and TC. Plasma and liver TC in the OP+OG group were significantly lower than those in the OP or OG groups. Both OP and OG increased the activity of liver cholesterol 7-hydroxylase (CYP7A1), while its activity in the OP+OG group was strongly increased compared with the OP or OG groups.These results indicated that dietary OP could improve hypercholesterolaemia, while dietary OP and OG together would have better hypocholesterolaemic effects.

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