Hu Q.,Institute of Field Surgery |
Hu L.,Institute of Field Surgery |
Jin X.-L.,Institute of Field Surgery |
Tian R.-Z.,Institute of Field Surgery |
Wang G.,Institute of Field Surgery
International Journal of Clinical and Experimental Medicine | Year: 2016
Objective: To systematically assess the efficacy of chemotherapy based on cisplatin combination with radiotherapy versus radiotherapy alone in the treatment of locally advanced cervical carcinoma. Methods: We comprehensively searched EMBase, PubMed, the Cochrane Library, VIP, CNKI, Chinese biomedicine literature database for randomized controlled trials comparing chemotherapy combination with radiotherapy versus radiotherapy alone in the treatment of locally advanced cervical carcinoma. Two reviewers independently assessed the quality of included studies and extracted data. We analyzed the data using Review Manager (version 5.2). Results: Nine randomized controlled trials were included totally. Meta-analysis showed that there were statistical difference between the radiotherapy alone group and chemotherapy combination with radiotherapy group in overall survival rate (RR = 1. 62, 95% CI: 1.34-1.95) and overall response rate (RR = 2.09, 95% CI: 1.642-2.65). Conclusion: Current evidence indicated that compared with radiotherapy alone, chemotherapy combination with radiotherapy could improve overall survival rate and overall response rate for patient with locally advanced cervical carcinoma. © 2016, International Journal of Clinical and Experimental Medicine. All rights reserved.
Li C.-H.,Institute of Field Surgery |
Huang Z.-Q.,Institute of Field Surgery |
Zhou C.,Institute of Field Surgery |
Pan K.,Institute of Field Surgery |
And 4 more authors.
Chinese Critical Care Medicine | Year: 2011
Objective: To propose a resuscitation fluid with a new formula for resuscitation of shock in battlefield on the basis of pathogenesis of hemorrhagic shock and clinical experiences, and to evaluate its safety and effectiveness in a rat hemorrhagic shock model. Methods: After hemorrhagic shock was reproduced in rats, a mixture of lactate Ringer solution and hydroxyethyl starch solution at 2:1 proportion (referred to as LH) was used for resuscitation in animals of control group; LH supplemented with dexamethasone and furosemide (referred to as LHDF) was used as resuscitation fluid for experimental group. After 4 hours of infusion, blood and major organs were obtained for serum biochemical tests, lung water content measurement and histopathological observation. Results: The mean arterial pressure of rats of both control and experimental groups recovered rapidly after resuscitation. There was no significant difference in the parameters of serum biochemistry between control group and experimental group. The wet/dry weight ratio of lung tissue in experimental group was significantly lower than control group (4.56±0.14 vs. 4.88±0.29, P<0.05). The blood alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in experimental group were also significantly lower than in control group [ALT: (73.02±41.89) U/L vs. (193.85±104.49) U/L; AST: (199.06±108.7) U/L vs. (395.25±137.08) U/L, both P<0.05). Diuretic effect was obviously observed in experimental group than control group [time of start urination, (76±20) minutes vs. (153±14) minutes) urine volume, (9.6±5.2) ml vs. (1.5±2.2) ml, P<0.01 and P<0.05], and the amount of ascitic fluid in experimental group was significantly lower than in control group [(1.3±0.6) ml vs. (5.0±3.0) ml, P<0.05). Histopathological observation of the liver, lung and intestine also showed less pathological changes in experimental group than in control group. Conclusion: The designed battlefield anti-shock fluid in this study has been shown to be effective in fluid resuscitation for hemorrhage shock in rats, with reduced tissue edema and less injury to the liver, lung and intestine.