Institute of Environmental Health and Related Products Safety

Beijing, China

Institute of Environmental Health and Related Products Safety

Beijing, China
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Lv Y.-B.,Institute of Environmental Health and Related Products Safety | Zhu P.-F.,Institute of Environmental Health and Related Products Safety | Yin Z.-X.,U.S. Center for Disease Control and Prevention | Kraus V.B.,Duke University | And 12 more authors.
Journal of the American Medical Directors Association | Year: 2017

Objectives Higher or lower blood pressure may relate to cognitive impairment, whereas the relationship between blood pressure and cognitive impairment among the elderly is not well-studied. The study objective was to determine whether blood pressure is associated with cognitive impairment in the elderly, and, if so, to accurately describe the association. Design Cross-sectional data from the sixth wave of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) conducted in 2011. Setting Community-based setting in longevity areas in China. Participants A total of 7144 Chinese elderly aged 65 years and older were included in the sample. Measures Systolic blood pressures (SBP) and diastolic blood pressures (DBP) were measured, pulse pressure (PP) was calculated as (SBP) − (DBP) and mean arterial pressures (MAP) was calculated as 1/3(SBP) + 2/3(DBP). Cognitive function was assessed via a validated Mini-Mental State Examination (MMSE). Results Based on the results of generalized additive models (GAMs), U-shaped associations were identified between cognitive impairment and SBP, DBP, PP, and MAP. The cutpoints at which risk for cognitive impairment (MMSE <24) was minimized were determined by quadratic models as 141 mm Hg, 85 mm Hg, 62 mm Hg, and 103 mm Hg, respectively. In the logistic models, U-shaped associations remained for SBP, DBP, and MAP but not PP. Below the identified cutpoints, each 1-mm Hg decrease in blood pressure corresponded to 0.7%, 1.1%, and 1.1% greater risk in the risk of cognitive impairment, respectively. Above the cutpoints, each 1-mm Hg increase in blood pressure corresponded to 1.2%, 1.8%, and 2.1% greater risk of cognitive impairment for SBP, DBP, and MAP, respectively. Conclusion A U-shaped association between blood pressure and cognitive function in an elderly Chinese population was found. Recognition of these instances is important in identifying the high-risk population for cognitive impairment and to individualize blood pressure management for cognitive impairment prevention. © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine


Shi X.M.,Institute of Environmental Health and Related Products Safety
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] | Year: 2016

OBJECTIVE: To explore the association between lipid ratios and all-cause mortality among elderly adults aged 80 years and older living in longevity areas of China.METHODS: A total of 874 participants in the Chinese Longitudinal Healthy Longevity Survey during June 2009 were included in our baseline survey. Lipid concentrations were measured and lipid ratios including LDL-C/HDL-C, TG/HDL-C, and atherosclerosis index (AI) were calculated at baseline, and the information on questionnaires, body measurement, and blood biochemical profiles was collected. Survival time and survival status were followed up in August 2012. Subjects were stratified into three groups (low, middle and high) by tertiles of lipid ratios. All-cause mortality was calculated. Cox regression models were used to assess the association of lipid ratios with mortality.RESULTS: During 38 months of follow-up, a total of 427 participants had died, 378 participants survived, and 69 participants were lost to follow-up; overall mortality was 50.5%. For these participants, P50 (P25-P75) values for LDL-C/HDL-C were 1.68 (1.22-2.05), 1.85 (1.34-2.16), and 1.78 (1.33-2.08), respectively (H=6.93, P=0.025); values for TG/HDL-C were 1.00 (0.79-1.34), 1.20 (0.97-1.53), and 1.23 (0.95-1.72), respectively (H=9.18, P=0.008). AIs were 2.12 (1.72-2.61), 2.27 (1.84-2.75), and 2.13 (1.80-2.58), respectively (H=6.37, P=0.041). Values for 38-month all-cause mortality were 53.1%, 50.0%, and 44.0% among participants with low, middle, and high LDL-C/HDL-C ratios (<1.39, 1.39-1.92, ≥1.92), respectively (χ(2)=7.54, P=0.024); these values were 54.8%, 46.4%, and 45.3% among participants with low, middle, and high AIs (<1.83, 1.83-2.39, ≥2.39), respectively (χ(2)=6.67, P=0.035). Each 1 unit increase of LDL-C/HDL-C, TG/HDL-C , and AI corresponded to a 17%, 15%, and 13% decrease in 38-month all-cause mortality, respectively; adjusted HRs were 0.83 (0.72-0.97), 0.85 (0.74-0.99), and 0.87 (0.76-0.99), respectively. Compared with participants who had low LDL-C/HDL-C ratios, high ratios were associated with lower risk of mortality (HR 0.88; (95% CI: 0.78-0.99)). Compared with low AIs, middle and high values were associated with lower risk of mortality HRs (95%CI) were 0.84 (0.72-0.98) and 0.87 (0.78-0.98);respectively.CONCLUSION: LDL-C/HDL-C, TG/HDL-C, and AI were negatively associated with all-cause mortality among elderly adults aged 80 years and older living in longevity areas of China.


Chen X.,Institute of Environmental Health and Related Products Safety | Ding L.,Institute of Environmental Health and Related Products Safety | He G.-L.,Institute of Environmental Health and Related Products Safety | Xu X.-Y.,Institute of Environmental Health and Related Products Safety | And 3 more authors.
Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis | Year: 2011

In the present paper, the method for determining the trace elements Be, Cd, As and Pb in air of residential areas by inductively coupled plasma-mass spectrometry was established. Ultrasonic leaching procedures were applied to extract the trace elements from the filter membrane of the atmospheric particulates. The operating condition of the instrument was optimized. 72Ge, 115In and 204Tl were chosen as the internal elements and the effect of matrix, interface and fluctuation of instrument was overcome effectively. Satisfactory linearity of working curves of four elements was obtained, giving all the correlation coefficients over 0.9995, and the detection limit of the method was between 0.006 and 0.045 ng·m-3. The mean values of National Standard Reference Material GBW (E)080212 were in agreement with the certified values. The sampling filters membranes, divided into four equal parts and with added standard solution with different concentions were analyzed, and the recovery rate of samples were in the range of 91.6%~109.7% with the related standard deviation between 0.7% and 4.8%. The obtained results showed that the method of determining the trace elements Be, Cd, As and Pb in air of residential areas by inductively coupled plasma-mass spectrometry proved to be simple, accurate, sophisticated and stable.


Zhang J.,Chongqing Medical University | Dai J.,Chongqing Medical University | Dai J.,Ministry of Education Key Laboratory of Child Development and Disorders | Yan L.,Ministry of Education Key Laboratory of Child Development and Disorders | And 6 more authors.
BioMed Research International | Year: 2016

Background. Prevalence of childhood asthma varies significantly among regions, while its reasons are not clear yet with only a few studies reporting relevant causes for this variation. Objective. To investigate the potential role of city-average levels of air pollutants and climatic factors in order to distinguish differences in asthma prevalence in China and explain their reasons. Methods. Data pertaining to 10,777 asthmatic patients were obtained from the third nationwide survey of childhood asthma in China's urban areas. Annual mean concentrations of air pollutants and other climatic factors were obtained for the same period from several government departments. Data analysis was implemented with descriptive statistics, Pearson correlation coefficient, and multiple regression analysis. Results. Pearson correlation analysis showed that the situation of childhood asthma was strongly linked with SO2, relative humidity, and hours of sunshine (p < 0.05). Multiple regression analysis indicated that, among the predictor variables in the final step, SO2 was found to be the most powerful predictor variable amongst all (β = - 19.572, p < 0.05). Furthermore, results had shown that hours of sunshine (β = - 0.014, p < 0.05) was a significant component summary predictor variable. Conclusion. The findings of this study do not suggest that air pollutants or climate, at least in terms of children, plays a major role in explaining regional differences in asthma prevalence in China. © 2016 Juanjuan Zhang et al.


PubMed | Capital Institute of Pediatrics, Institute of Environmental Health and Related Products Safety, Chongqing Medical University and Ministry of Education Key Laboratory of Child Development and Disorders
Type: | Journal: BioMed research international | Year: 2016

Background. Prevalence of childhood asthma varies significantly among regions, while its reasons are not clear yet with only a few studies reporting relevant causes for this variation. Objective. To investigate the potential role of city-average levels of air pollutants and climatic factors in order to distinguish differences in asthma prevalence in China and explain their reasons. Methods. Data pertaining to 10,777 asthmatic patients were obtained from the third nationwide survey of childhood asthma in Chinas urban areas. Annual mean concentrations of air pollutants and other climatic factors were obtained for the same period from several government departments. Data analysis was implemented with descriptive statistics, Pearson correlation coefficient, and multiple regression analysis. Results. Pearson correlation analysis showed that the situation of childhood asthma was strongly linked with SO2, relative humidity, and hours of sunshine (p < 0.05). Multiple regression analysis indicated that, among the predictor variables in the final step, SO2 was found to be the most powerful predictor variable amongst all ( = -19.572, p < 0.05). Furthermore, results had shown that hours of sunshine ( = -0.014, p < 0.05) was a significant component summary predictor variable. Conclusion. The findings of this study do not suggest that air pollutants or climate, at least in terms of children, plays a major role in explaining regional differences in asthma prevalence in China.


PubMed | Institute of Environmental Health and Related Products Safety
Type: Journal Article | Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] | Year: 2016

To explore the association between lipid ratios and all-cause mortality among elderly adults aged 80 years and older living in longevity areas of China.A total of 874 participants in the Chinese Longitudinal Healthy Longevity Survey during June 2009 were included in our baseline survey. Lipid concentrations were measured and lipid ratios including LDL-C/HDL-C, TG/HDL-C, and atherosclerosis index (AI) were calculated at baseline, and the information on questionnaires, body measurement, and blood biochemical profiles was collected. Survival time and survival status were followed up in August 2012. Subjects were stratified into three groups (low, middle and high) by tertiles of lipid ratios. All-cause mortality was calculated. Cox regression models were used to assess the association of lipid ratios with mortality.During 38 months of follow-up, a total of 427 participants had died, 378 participants survived, and 69 participants were lost to follow-up; overall mortality was 50.5%. For these participants, P50 (P25-P75) values for LDL-C/HDL-C were 1.68 (1.22-2.05), 1.85 (1.34-2.16), and 1.78 (1.33-2.08), respectively (H=6.93, P=0.025); values for TG/HDL-C were 1.00 (0.79-1.34), 1.20 (0.97-1.53), and 1.23 (0.95-1.72), respectively (H=9.18, P=0.008). AIs were 2.12 (1.72-2.61), 2.27 (1.84-2.75), and 2.13 (1.80-2.58), respectively (H=6.37, P=0.041). Values for 38-month all-cause mortality were 53.1%, 50.0%, and 44.0% among participants with low, middle, and high LDL-C/HDL-C ratios (<1.39, 1.39-1.92, 1.92), respectively ((2)=7.54, P=0.024); these values were 54.8%, 46.4%, and 45.3% among participants with low, middle, and high AIs (<1.83, 1.83-2.39, 2.39), respectively ((2)=6.67, P=0.035). Each 1 unit increase of LDL-C/HDL-C, TG/HDL-C , and AI corresponded to a 17%, 15%, and 13% decrease in 38-month all-cause mortality, respectively; adjusted HRs were 0.83 (0.72-0.97), 0.85 (0.74-0.99), and 0.87 (0.76-0.99), respectively. Compared with participants who had low LDL-C/HDL-C ratios, high ratios were associated with lower risk of mortality (HR 0.88; (95% CI: 0.78-0.99)). Compared with low AIs, middle and high values were associated with lower risk of mortality HRs (95%CI) were 0.84 (0.72-0.98) and 0.87 (0.78-0.98);respectively.LDL-C/HDL-C, TG/HDL-C, and AI were negatively associated with all-cause mortality among elderly adults aged 80 years and older living in longevity areas of China.

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