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Chen R.,Fudan University | Zhao A.,Fudan University | Chen H.,U.S. National Institutes of Health | Zhao Z.,Fudan University | And 8 more authors.
Journal of the American College of Cardiology | Year: 2015

Background Indoor exposure to fine particulate matter (PM2.5) from outdoor sources is a major health concern, especially in highly polluted developing countries such as China. Few studies have evaluated the effectiveness of indoor air purification on the improvement of cardiopulmonary health in these areas. Objectives This study sought to evaluate whether a short-term indoor air purifier intervention improves cardiopulmonary health. Methods We conducted a randomized, double-blind crossover trial among 35 healthy college students in Shanghai, China, in 2014. These students lived in dormitories that were randomized into 2 groups and alternated the use of true or sham air purifiers for 48 h with a 2-week washout interval. We measured 14 circulating biomarkers of inflammation, coagulation, and vasoconstriction; lung function; blood pressure (BP); and fractional exhaled nitric. We applied linear mixed-effect models to evaluate the effect of the intervention on health outcome variables. Results On average, air purification resulted in a 57% reduction in PM2.5 concentration, from 96.2 to 41.3 μg/m3, within hours of operation. Air purification was significantly associated with decreases in geometric means of several circulating inflammatory and thrombogenic biomarkers, including 17.5% in monocyte chemoattractant protein-1, 68.1% in interleukin-1β, 32.8% in myeloperoxidase, and 64.9% in soluble CD40 ligand. Furthermore, systolic BP, diastolic BP, and fractional exhaled nitrous oxide were significantly decreased by 2.7%, 4.8%, and 17.0% in geometric mean, respectively. The impacts on lung function and vasoconstriction biomarkers were beneficial but not statistically significant. Conclusions This intervention study demonstrated clear cardiopulmonary benefits of indoor air purification among young, healthy adults in a Chinese city with severe ambient particulate air pollution. © 2015 American College of Cardiology Foundation Published By Elsevier Inc.


Bai Y.,Peking University | Sun Q.,Peking University | Sun Q.,Institute of Environmental Health and Related Product Safety | Xing R.,Peking University | And 2 more authors.
Applied Microbiology and Biotechnology | Year: 2011

The denitrifier community and associated nitrate and nitrite reduction in the bioaugmented and general sequencing batch reactors (SBRs) during the treatment of coking wastewater containing pyridine and quinoline were investigated. The efficiency and stability of nitrate and nitrite reduction in SBR was considerably improved after inoculation with four pyridine- or quinoline-degrading bacterial strains (including three denitrifying strains). Terminal restriction fragment length polymorphism (T-RFLP) based on the nosZ gene revealed that the structures of the denitrifier communities in bioaugmented and non-bioaugmented reactors were distinct and varied during the course of the experiment. Bioaugmentation protected indigenous denitrifiers from disruptions caused by pyridine and quinoline. Clone library analysis showed that one of the added denitrifiers comprised approximately 6% of the denitrifier population in the bioaugmented sludge. © 2011 Springer-Verlag.


Chang J.,Institute of Environmental Health and Related Product Safety
Wei sheng yan jiu = Journal of hygiene research | Year: 2012

To establish the determination of gaseous nicotine in ambient air using high performance liquid chromatography. The nicotine samples of ambient air were collected by passive air samples. The Sample film was sonicated, extracted, evaporated with nitrogen sweeping, and dissolved with the mobile phase. Nicotine was separated by C18 reversed-phase column, examined by ultraviolet detector, quantified by peak area and qualitatively measured by its retentive time. The limit of detection and the limit of quantification is 30 ng/mL, 101 ng/mL, respectively. The precision is characterized by RSD in the rage 0.24% -2.62%. The average recovery of sample is in the rage of 82.0% -107.2%. The samples can be kept more than 11 days in the dry state of room temperature after sealing. The method is suitable for the determination of nicotine concentration in public places air.


Fu H.,Institute of Environmental Health and Related Product Safety
Wei sheng yan jiu = Journal of hygiene research | Year: 2012

To develop a method for determination of the Metronidazole, Chlortetracycline hydrochloride, Oxytetracycline dihydrate, Minocycline hydrochloride, Erythromycin and Tetracycline hydrochloride in disinfection products by high performance liquid chromatography tandem mass spectrometry(LC-MS/MS). Samples were extracted by methanol and filtered through 0.45 microm PTFE membrane filter, then analyzed by LC-MS/MS using Waters Symmetry C18 (2.1 mm x 150 mm, 3.5 microm) column in positive ion scan mode. The mobile phase was 5 mmol/L ammonium acetate, methanol and acetonitrile. The linear range was 0-2000 ng/ml and the correlation coefficients were more than 0.998, the average recoveries ranged from 74.7% to 114% with the relative standard deviations between 1.6%-20.2%. The method was successfully used to detect the content of antibiotics in 115 disinfection products. The method is simple, sensitive, selective and suitable for the analysis of residual content of antibiotics in cream formulations of disinfection products.


Bai Y.,CAS Research Center for Eco Environmental Sciences | Bai Y.,Peking University | Sun Q.,Institute of Environmental Health and Related Product Safety | Wen D.,Peking University | Tang X.,Peking University
FEMS Microbiology Ecology | Year: 2012

Nitrification plays a significant role in the global nitrogen cycle. Ammonia oxidation, the first step of nitrification, is performed in wastewater treatment by both ammonia-oxidizing bacteria (AOB) and ammonia-oxidizing archaea (AOA). Most previous studies focused on their distribution in natural environments. In this study we qualified and quantified AOB, AOA, total bacteria, and total archaea in six different wastewater treatment systems (WTSs) using clone library and real-time PCR techniques. The results revealed that wastewater quality was an essential factor for the distribution of AOB and AOA in aerobic reactors. Although both AOB and AOA were present in all samples and contributed to nitrification simultaneously, AOB were the dominant nitrifiers in the three industrial WTSs, whereas AOA were dominant in the three domestic WTSs. This indicates AOA may be more sensitive to some toxic compounds than AOB. In addition, the dominant groups of AOB in the industrial WTSs were Nitrosomonas and Nitrosospira; the composition of AOA in the domestic WTSs was very similar, possibly due to © 2012 Federation of European Microbiological Societies.

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