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Home > Press > The world-renowned Memorial Sloan Kettering Cancer Center in New York City uses a Renishaw inVia confocal Raman microscope, in the Kircher Laboratory, to support the development of nanomolecular probes Abstract: The Kircher laboratory at Memorial Sloan Kettering is developing novel nanoprobes for molecular imaging, image-guided therapy and theranostics. Its ultimate goal is to develop a universal technology that allows precise determination of the actual spread of a tumour in vivo. Currently surgeons cannot see the microscopic extent of the tumour during a procedure, which is essential information for tumor removal and avoiding excess tissue excision. Physician-scientist Dr. Moritz Kircher is working on a new generation of nanometer-sized imaging beacons. These allow detection, during surgeries and minimally invasive procedures, of the macroscopic extent of the primary tumour, its true microscopic spread, as well information on satellite micrometastases. These nanobeacons can be located using surface enhanced resonance Raman scattering (SERRS), which can be combined with other whole-body imaging methods, such as magnetic resonance imaging (MRI) or positron emission tomography (PET). SERRS is a highly sensitive technique utilising a resonance Raman effect, combined with a surface enhancement obtained from nanoparticles to give dramatic enhancements to the normally weak Raman signal. The advantages of the SERRS method is also utilised by Renishaw Diagnostics in their recently launched CE certified RenDX Fungiplex assay IVD device. Dr. Kircher is a member of the Department of Radiology, the Center for Molecular Imaging and Nanotechnology and the Brain Tumor Center. He chose the Renishaw inVia confocal Raman microscope for the Kircher Laboratory, following his positive experience of using the instrument–and the successful research he obtained–during his post-doctoral studies at Stanford University, in the group of Professor Sam Gambhir. He has gone on to publish several high profile papers using inVia's results.1 Dr. Kircher said, “Our aims are to visualise any cancer type with the ultrasensitive Raman nanostar particles my group has developed. This includes providing high precision intraoperative guidance to surgeons, so that they can, with confidence, visualise and excise all cancer cells completely and without having to sacrifice too much normal tissue around the tumour. In addition, our SERRS nanoparticles are not only universal with regards to tumour type, they also allow us to detect microscopic tumour extensions from the main tumour into the periphery, microscopic loco regional metastases and even premalignant lesions.” Most recently, the group has published an overview paper in the Journal of Nuclear Medicine2 which cites SERRS as a new modality for cancer imaging. The authors concluded that the increased accuracy in visualising the full extent of tumour spread provided by the SERRS signal could increase the precision with which cancers can be resected or destroyed, be it via open surgery or minimally invasive techniques used by interventional radiologists. With the application of SERRS in diagnostics and cancer detection the future for the application of Raman spectroscopy in this field looks very promising. For further details about Renishaw's inVia confocal Raman microscope, visitwww.renishaw.com/invia. References 1 Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging, Harmsen et al, Science Translational Medicine 21 Jan 2015: Vol. 7, Issue 271, pp. 271ra7, DOI: 10.1126/scitranslmed.3010633 2 Surface-Enhanced Raman Spectroscopy: A New Modality for Cancer Imaging, Andreou, Kishore & Kircher, J Nucl Med 2015; 56:1–5, DOI: 10.2967/jnumed.115.158196 Acknowledgement Professor S Maruyama and Dr S Chiashi would like to acknowledge the co-operation of the Laser Alliance at Institute of Engineering Innovation, School of Engineering, University of Tokyo. About Renishaw Renishaw is one of the world's leading engineering and scientific technology companies, with expertise in precision measurement and healthcare. The company supplies products and services used in applications as diverse as jet engine and wind turbine manufacture, through to dentistry and brain surgery. It is also a world leader in the field of additive manufacturing (also referred to as 3D printing), where it is the only UK business that designs and makes industrial machines which ‘print’ parts from metal powder. The Renishaw Group currently has more than 70 offices in 33 countries, with around 4,000 employees, of which 2,700 people are employed within the UK. The majority of the company's R&D and manufacturing is carried out in the UK and for the year ended June 2015 Renishaw achieved sales of £494.7 million of which 95% was due to exports. The company's largest markets are the USA, China, Germany and Japan. The Company's success has been recognised with numerous international awards, including eighteen Queen's Awards recognising achievements in technology, export and innovation. Renishaw received a Queen's Award for Enterprise 2014, in the Innovations category, for the continuous development of the inVia confocal Raman microscope. 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Hojo H.,Institute of Engineering Innovation | Mizoguchi T.,University of Tokyo | Ohta H.,Nagoya University | Ohta H.,Japan Science and Technology Agency | And 8 more authors.
Nano Letters | Year: 2010

Determining both cation and oxygen sublattices of grain boundaries is essential to understand the properties of oxides. Here, with scanning transmission electron microscopy, electron energy-loss spectroscopy, and first-principles calculations, both the Ce and oxygen sublattices of a (210)Σ5 CeO2 grain boundary were determined. Oxygen vacancies are shown to play a crucial role in the stable grain boundary structure. This finding paves the way for a comprehensive understanding of grain boundaries through the atomic scale determination of atom and defect locations. © 2010 American Chemical Society.

Nakamura A.,Institute of Engineering Innovation | Furutsuki S.,University of Tokyo | Nishimura S.-I.,University of Tokyo | Tohei T.,Institute of Engineering Innovation | And 7 more authors.
Chemistry of Materials | Year: 2014

A variety of cathode materials in lithium ion batteries exhibit phase separations during electrochemical reactions, where two phases with different Li compositions are in equilibrium across the phase interface. Because of the lattice mismatch between these phases, large structural distortions are introduced around the interface region. To characterize their potential effect upon the Li migration behavior, the phase interface structure should be determined accurately. In this study, we perform sophisticated structural analyses for phase interfaces in the well-known cathode material LixFePO4, using atomic resolution scanning transmission electron microscopy. The lattice deformation behavior and Li composition gradient are separately measured across the interface and superimposed after spatial calibrations. The combined result reveals that their relationship significantly deviates from simple models, such as Vegard's law or other higher order interpolations. Notably, the interface region has small lattice sizes comparable to the FePO4 phase, while having intermediate Li compositions. The origin of observed structure is discussed considering the local phase stability by estimating the pair distance variations of dominant attractive/repulsive ionic couples. Because of the nonlinear variations of each structural parameter, well-optimized experiments with high spatial resolutions and sufficient accuracies are required to correctly understand the phase interface structures. © 2014 American Chemical Society.

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