Liu Y.,Shenyang Pharmaceutical University |
Liu Y.,Institute of Drug Research in Benxi |
Wang X.,Shenyang Pharmaceutical University |
Wang X.,Institute of Drug Research in Benxi |
And 14 more authors.
Advanced Synthesis and Catalysis | Year: 2015
A microwave-irradiated alcohol-protecting strategy based on gold catalysis utilizing benzyl alcohol, tert-butyl alcohol and triphenylmethanol as alkylating reagents has been developed. This protecting strategy has wide functional group tolerance with satisfactory yields for the majority of the selected alcohols. The mechanism of this transformation was probed with oxygen-18 isotope labelled alcohols assisted by GC-MS techniques and chemical kinetic experiments. This strategy provides an efficient, straightforward and alternative approach to the preparation of benzyl, tert-butyl and trityl ethers in organic synthesis. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.