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Stefan N.,University Hospital Tu Bingen | Stefan N.,Institute of Diabetes Research and Metabolic Diseases | Sun Q.,Harvard University | Fritsche A.,University Hospital Tu Bingen | And 18 more authors.
PLoS ONE | Year: 2014

Background: Among adipokines and hepatokines, adiponectin and fetuin-A were consistently found to predict the incidence of type 2 diabetes, both by regulating insulin sensitivity. © 2014 Stefan et al.

Stefan N.,University of Tubingen | Stefan N.,Institute of Diabetes Research and Metabolic Diseases | Stefan N.,German Center for Diabetes Research | Artunc F.,University of Tubingen | And 9 more authors.
Nephrology Dialysis Transplantation | Year: 2016

The prevalence of obesity is increasing worldwide and contributes to many health problems, including kidney disease. Unexpectedly, 10-30% of obese individuals are apparently not at increased risk of metabolic diseases, e.g. type 2 diabetes, cardiovascular disease and risk of renal disease. Their phenotype is labeled 'metabolically healthy obesity'. In the search for mechanisms explaining this unexpected condition, a favourable type of body fat distribution with low insulin resistance and with low subclinical inflammation has been identified. Furthermore, signalling pathways have been found that distinguish between metabolically benign and malignant obesity. In addition, the important roles of fatty acids, adipokines and hepatokines were identified. These factors regulate insulin resistance and subclinical inflammation. Onset and evolution of chronic kidney disease (CKD) are affected by obesity. CKD also increases the risk of insulin resistance and subclinical inflammation, two pathways that play an important role in the pathogenesis of renal malfunction. This brief review summarizes novel insights, specifically how distinct body fat compartments (including perivascular and even renal sinus fat) may have an impact on progression of CKD. © 2014 The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

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