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Buenos Aires, Argentina

Torralva T.,INECO Institute of Cognitive Neurology | Torralva T.,Diego Portales University | Torralva T.,University of Buenos Aires | Gleichgerrcht E.,INECO Institute of Cognitive Neurology | And 12 more authors.
Psychiatry Research | Year: 2013

The relationship between decision making and theory of mind (TOM) has been hardly investigated in patients with Asperger Syndrome (AS). Here, we show that the AS group (n=25) exhibited deficits on a complex TOM task, yet were unimpaired in a decision-making test. No association was found between these two domains. © 2012 Elsevier Ireland Ltd. Source

Sedeno L.,University of Buenos Aires | Sedeno L.,Diego Portales University | Sedeno L.,CONICET | Couto B.,University of Buenos Aires | And 32 more authors.
PLoS ONE | Year: 2014

Depersonalization-Derealization Disorder (DD) typically manifests as a disruption of body self-awareness. Interoception - defined as the cognitive processing of body signals - has been extensively considered as a key processing for body self-awareness. In consequence, the purpose of this study was to investigate whether there are systematic differences in interoception between a patient with DD and controls that might explain the disembodiment symptoms suffered in this disease. To assess interoception, we utilized a heartbeat detection task and measures of functional connectivity derived from fMRI networks in interoceptive/exteroceptivo/mind-wandering states. Additionally, we evaluated empathic abilities to test the association between interoception and emotional experience. The results showed patient's impaired performance in the heartbeat detection task when compared to controls. Furthermore, regarding functional connectivity, we found a lower global brain connectivity of the patient relative to controls only in the interoceptive state. He also presented a particular pattern of impairments in affective empathy. To our knowledge, this is the first experimental research that assesses the relationship between interoception and DD combining behavioral and neurobiological measures. Our results suggest that altered neural mechanisms and cognitive processes regarding body signaling might be engaged in DD phenomenology. Moreover, our study contributes experimental data to the comprehension of brain-body interactions and the emergence of self-awareness and emotional feelings. © 2014 Sedeño et al. Source

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