Research Institute of Clinical Immunology SB RAMS

Novosibirsk, Russia

Research Institute of Clinical Immunology SB RAMS

Novosibirsk, Russia
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Sakhno L.V.,Research Institute of Clinical Immunology SB RAMS | Shevela E.Ya.,Research Institute of Clinical Immunology SB RAMS | Chernykh E.R.,Research Institute of Clinical Immunology SB RAMS
Immunologiya | Year: 2015

Macrophages are cells of innate immunity and play an important role in protecting the body from pathogenic impact, maintaining tissue homeostasis, elimination of aging, neoplastic or damaged cells) and the healing process. Cells of the monocyte-macrophage series are characterized by the diversity of response to a changing microenvironment, which indicates a high plasticity of macrophages. Analysis of literature data reveals at least two functional type macrophages - classical proinflammatory and anti-inflammatory macrophages, called M1 and M2 cells, respectively. M1 and M2 cells have phenotypic features and characteristics for each type cytokine profile. Study of the functions of macrophage cells showed that the activity of M1 and M2 macrophages boxer by nature: inflammatory versus anti-inflammatory, immunogenic against tolerogenic activity, tissue-destructive against reparative activity. The involvement of M2 macrophages in the resolution of inflammation and stimulation of reparative processes demonstrates the therapeutic potential of these cells and allows to consider them as potential candidates for the stimulation of reparative processes.

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