Nartsissov Y.R.,Institute of Citochemistry and Molecular Pharmacology |
Tyukina E.S.,Institute of Citochemistry and Molecular Pharmacology |
Boronovsky S.E.,Institute of Citochemistry and Molecular Pharmacology |
Sheshegova E.V.,Institute of Citochemistry and Molecular Pharmacology
Biophysics (Russian Federation) | Year: 2013
A method for quantitative assessment of the metabolite concentrations in digital phantoms of the biological objects has been proposed. The objects under consideration are expected to have a complex geometry of diffusive sources. We present an algorithm for calculation of non-steady state gradients of the diffusing compounds under their constant border concentration. The algorithm is based on the analytical solutions for a centrally symmetric spherical source. Spatial-time distribution of metabolites is considered by the example of glucose diffusion around blood vessels in the rat brain pial. It was shown that glucose level in the tissue was increased after glycine treatment and under condition of other biological system parameters to be unchanged. © 2013 Pleiades Publishing, Inc.