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Lee G.S.,Sahmyook University | Lee G.S.,Institute of Chronic Disease | Yim D.,Sahmyook University | Cheong J.H.,Sahmyook University | And 2 more authors.
Immunopharmacology and Immunotoxicology | Year: 2012

Our previous report showed that Hydnocarpi Semen (HS) extract has wound repair activity at ulcer lesion in diabetic mice. In this study, fractions of n-Hexane, ethylacetate (EtOAc), and butanol (BuOH) from HS crude extract were evaluated for their wound healing activity by using in vivo diabetic ulcer models and in vitro acute inflammation model. Although n-Hexane and EtOAc fractions promote wound healing in mice with ulcer, the BuOH fraction exhibited the most potent wound healing activity and the wound area score significantly decreased after treatment of BuOH fraction even at dose of 2 mg/kg. BuOH fraction stimulated macrophages to increase the production of nitric oxide (NO) and TNF-α. The BuOH fraction also enhanced the production of TGF-β and VEGF, which were involved in fibroblast activation and angiogenesis. The mRNA expression and activation of MMP-9 were increased by three fractions and the activity was higher in BuOH fraction-treated group compared to the other groups. The mechanism that the HS helps to promote healing of diabetic ulcer is possibly associated with the production of TNF-α, a proinflammatory cytokine, as well as the secretion of VEGF, TGF-β, and MMP-9, which were involved in proliferation of capillaries and fibroblasts. These results suggest that HS can be a new candidate material for the treatment of wound in skin ulcer. © 2012 Informa Healthcare USA, Inc.

Xiaoli Y.,Institute of Chronic Disease | Chao J.,Dalian Medical University | Wen P.,Institute of Chronic Disease | Wenming X.,Panjin Oil Field Center for Disease Control and Prevention | And 12 more authors.
PloS one | Year: 2014

BACKGROUND: To describe the prevalence of DSM-IV disorders and comorbidity in a large school-based sample of 6-17 year old children and adolescents in northeast China.METHODS: A two-phase cross-sectional study was conducted on 9,806 children. During the screening phase, 8848 children (90.23%) and their mothers and teachers were interviewed using the Strengths and Difficulties Questionnaire (SDQ). During the diagnostic phase, 1129 children with a positive SDQ and 804 randomly selected children with a negative SDQ (11%), and their mothers and teachers, were interviewed using the Development and Well-Being Assessment (DAWBA).RESULTS: The overall prevalence of DSM-IV disorders was 9.49% (95% CI = 8.10-11.10%). Anxiety disorders were the most common (6.06%, 95% CI = 4.92-7.40), followed by depression (1.32%, 95% CI = 0.91-1.92%), oppositional defiant disorder (1.21%, 95%CI = 0.77-1.87) and attention-deficit hyperactivity disorder (0.84%, 95% CI = 0.52-1.36%). Of the 805 children with a psychiatric disorder, 15.2% had two or more comorbid disorders.CONCLUSIONS: Approximately one in ten Chinese school children has psychiatric disorders involving a level of distress or social impairment likely to warrant treatment. Prevention, early identification and treatment of these disorders are urgently needed and pose a serious challenge in China.

Mu H.,Institute of Chronic Disease | Li Y.,Institute of Chronic Disease | Liu L.,Institute of Chronic Disease | Na J.,Institute of Chronic Disease | And 9 more authors.
BMC Psychiatry | Year: 2016

Background: To describe the level and risk factors for suicidal behaviors in Chinese men who have sex with men (MSM). Methods: A total of 807 MSM were recruited using a respondent-driven sampling method from Anshan, Benxi, Dandong, and Shenyang cities in northeastern China. Results: Chinese MSM had lifetime prevalences of suicide ideation (18.3%), plan (8.7%) and attempt (4.6%) that were about 2.8, 5.8 and 5.8 times greater than that of male adults in the general population of China. The MSM with any psychiatric disorders were 4-7 times more likely to think about, plan or attempt suicide than those MSM with no disorder, and there was a clear relationship between the number of comorbid disorders and suicidal behaviors. Multiple regression analysis showed that major depression, bipolar disorder, dysthymia and alcohol use disorder significantly increased the risk for suicide ideation, but not for suicide attempt. Drug dependence disorder, panic disorder and generalized anxiety disorder significantly increased the risk for suicide attempt, but not for suicide ideation. More advanced education reduced the risk of suicidal behaviors, sexual orientations revealed to or discovered by family members or friends significantly increased risk of these suicidal behaviors. Conclusions: Chinese MSM have significantly increased risk for suicidal behaviors, mental disorders and their comorbidities could be the largest risk factors for the elevated suicidal behaviors in Chinese MSM. Reducing the family and social stigma and rejection of homosexual behavior and early detection and effective treatment of psychiatric disorders and their comorbidities in MSM may help to decrease suicidal behaviors of Chinese MSM. © 2016 Mu et al.

Wu Y.,Institute of Chronic Disease | Xu X.,Institute of Chronic Disease | Zeng B.,Institute of Chronic Disease | Xiang R.,Institute of Chronic Disease | And 3 more authors.
Chinese Journal of Endemiology | Year: 2015

Objective To comprehensively study the oxidative stress of bone tissue in rats with chronic fluorosis treated with anti-oxidant, the oxidative damage of lipid, protein and DNA. Methods Forty Wistar rats weaned 2 weeks were randomized by weight and divided into 4 groups according to body weight, control group (treated with tap water) and 3 NaF (sodium fluoride) exposure groups (treated with NaF at 50, 150 and 250 mg/L), 5 female rats and 5 male rats in each group. NaF was given through drinking water. After 6 months of treatment, a 12- hour urine samples were collected, then rats were killed, serum was collected, right rear tibiofibula was separated. Bone and urinary fluoride content and incidence rate of dental fluorine were studied and the levels of bone tissue suppression function of hydroxy free radical, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), 8-hydroxydeoxyguanosine (8-OHdG), protein carbonyls (PCO), and malonaldehyde (MDA) were assayed. Results (1)Results of suppression function of hydroxy free radical: The difference of bone tissue suppression function of hydroxy free radical among control [(22.99 ± 4.31)U/mg prot], low-excess dose [(22.76 ± 8.11)U/mg prot], medium-excess dose [(13.47 ± 4.56)U/mg prot) and high-excess dose [(19.40 ± 5.92)U/mg prot] groups was statistically significant (F = 5.01, P < 0.05). (2) Results of SOD: The difference of bone tissue SOD among control [(5.06 ± 1.16)U/mg prot], low-excess dose [(5.32 ± 1.18)U/mg prot], medium-excess dose [(3.71 ± 0.72)U/mg prot] and high-excess dose [(4.80 ± 1.10)U/mg prot] groups was statistically significant (F = 4.44, P < 0.05). (3) Results of CAT: The difference of hone tissue CAT among control [(25.20 ± 5.91)U/mg prot], low-excess dose [(22.53 ± 7.10) U/mg prot], medium-excess dose [(17.96 ± 4.7l)U/mg prot] and high-excess dose [(19.52 ± 5.52)U/ mg prot] groups was statistically significant (F = 2.85, P < 0.05). (4) Results of GSH-Px: "Hie differences of bone tissue GSH-Px among control [(52.86 ± 12.88)U/mg prot], low-excess dose [(70.05 ± 15.72)U/mg prot], medium-excess dose [(51.55 ± 6.97)U/mg prot] and high-excess dose [(57.47 ± 10.99) U/mg prot] groups was statistically significant (F = 4.89, P < 0.05). (5)Results of PCO: The different' es of bone tissue PCO among control {(58.73 ± 20.86)ng/I.], low-excess dose [(89.41 ± 26.20)ng/L], medium-excess dose [(97.07 ± 22.24)ng/L] and high- excess dose [(83.96 ± 29.55)ng/L] groups was statistically significant (F = 4.43, P < 0.05). (6) Results of 8-OHdG: The differences of bone tissue 8-OHdG among control [(87.66 ± 6.32)ng/L], low-excess dose [(86.31 ± 6.30)ng/L], medium-excess dose [(92.17 ± 4.28)ng/L] and high-excess dose ((88.02 ± 6.14)ng/L] groups was not statistically significant (F= 1.88 ,P > 0.05). (7) Results of MDA: The differences of bone tissue MDA among control [(3.70 ± 1.73) nmol/mg prot], low-excess dose [(2.10 ± 0.95)nmol/mg prot], medium-excess dose [(3.32 ± 2.20)nmol/mg prot] and high-excess dose [(2.71 ± 2.18)nmol/mg prot] groups was not statistically significant (F = 1.37, P > 0.05). Conclusions The activity of SOD and CAT of lione tissue are inhibited and suppression function of hydroxy free radical is decreasing under fluorosis influence, which results in protein damage. Oxidative stress is considered to be one of the mechanisms of skeletal fluorosis.

Zhang B.,Institute of Chronic Disease | Xiong P.,Institute of Chronic Disease | Zhu S.,Institute of Chronic Disease | Zhou S.,Institute of Chronic Disease | And 3 more authors.
Chinese Journal of Endemiology | Year: 2015

Objective To investigate and analyze the examination and acceptance results for coal - burning-borne endemic fluorosis control and elimination in Hubei Province. Methods A county-level self- inspection and a provincial-level spot-check were conducted to investigate the status of improved-stove usage, the situation of correctly drying corn and chili, and the dental fluorosis prevalence among children aged 8 to 12 in 501 historic coal-burning-borne endemic fluorosis villages of 6 counties (cities) in Hubei Province from 2012 to 2014. The endemic areas were selected according to the "Control Standards of Endemic Fluorosis in Endemic Areas" (GB 17017-2010) and "Eliminating Standards of Coal-burning Type Endemic Fluorosis". Results The results of county-level inspection showed that the qualified rates of improved stoves, the correct-usage rates of qualified stoves, and the correctly drying rates of corn and chili were all higher than 98% in targeted villages, and the prevalence rate of dental fluorosis of children was 7.73% (2 319/30 003). The results of provincial-level recheck were more than 99% and 8.25% (353/4 277), respectively. The results of county-level inspection were of good consistency with those of provincial-level recheck (88.89%, 48/54). Five counties (cities) but one had met the standard of fluorosis control or elimination. Conclusion Coal-burning-borne endemic fluorosis scope in Hubei Province is narrowed greatly and the prevalence rates are decreased significantly.

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