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Zheng L.,Zhejiang University | Wang R.,Zhejiang University | Chen B.,Institute of Chinese Medicine | Fu C.,Zhejiang University
Life Science Journal | Year: 2013

Although Atractylodes macrocephala is an important economically medicinal plant with a centuries' cultivation history, our understanding of its morphological variation remains rudimentary. Here, in order to generate information on character association, and influence of characters on rhizome yield of cultivated Atractylodes macrocephala, variability, correlation and principal component analysis for 21 morphological characters were studied on 100 morphologically distinct accessions of this medicinal crop. The significant and positive correlation for dry rhizome yield per plant was observed with the largest diameter, number of buds, number of branches and shape of the rhizome, and closely followed by primary branches per plant, plant height, plant crown, and apical lobule length and width of the largest lower leaf. Factor analysis was also used for defining of the determinant factors and the characters constituted in each factor. In Principal component analysis (PCA), the first four main and independent factors could explain 65.75% of the total variation related to main effective characters. Additionally, the results grouped the accessions into two clusters based the scatter plot of principal component analysis defined by the first two axes, which separated accessions with more than two-branched rhizome from other accessions. This characterization on the basis of morphological analysis will help in identification of economically useful accessions for further germplasm conservation programmes and crop improvement.

Kwok T.,Prince of Wales Hospital | Leung P.C.,Institute of Chinese Medicine | Lam C.,CUHK | Ho S.,Community and Family Medicine | And 3 more authors.
Complementary Therapies in Medicine | Year: 2014

Background: Danshen (Salvia miltiorrhiza) and Gegen (Radix puerariae) (D&G) are two herbs frequently used for the treatment of angina and other cardiac symptoms in Chinese materia medica. Recent studies have demonstrated their cardio-protective and anti-atherosclerosis effects. Earlier we have conducted two clinical trials in 2004 and 2007 which demonstrated such effects in extremely high risk patients. Study objective: The aim of the study was to demonstrate the safety and effectiveness of D&G in the prevention of atherosclerosis in postmenopausal women with early hypercholesterolemia. Design: The study was designed as a randomized, double-blinded, placebo-controlled trial with a 12-month treatment period. Subject: A population based sample of 165 postmenopausal women aged 47-65 were included in the trial. Only women who experienced menopause for more than 12 months were recruited. Interventions: The eligible subjects were randomized to take the D&G preparation (two capsules), or image-identical placebo capsules (two capsules) daily, in a double-blind and parallel fashion for 12 month. © 2014 Elsevier Ltd.

Li M.,Institute of Chinese Medicine | Yang M.-H.,Institute of Chinese Medicine | Liu Y.,Institute of Chinese Medicine | Luo X.-D.,Guangdong Provincial Hospital of Traditional Chinese Medicine | And 2 more authors.
Chinese Journal of Integrative Medicine | Year: 2015

Objective: To analyze the clinical evaluation of Parkinson’s disease (PD) patients receiving integrated Chinese and Western medicine therapy.Methods: One hundred and twenty patients were enrolled and randomly allocated to a control group or treatment group. Patients in the two groups received placebo and Bushen Huoxue Granule (补肾活血颗粒, BHG), respectively. Both groups received baseline levodopa and benserazide (Madopar). The effects of treatment were assessed monthly during the 9-month treatment. Means of evaluation included Unified PD Rating Scale (UPDRS) scores (II and III), sleep scale score, 10 m turn back test (getting up time, 10 m×2 times, and turning time), timing motor test (TMT)-left and TMT-right, which were treated as the dependent variables; and age, sex, duration of PD, Hoehn and Yahr (H-Y) stage and Madopar dosage of admitted PD patients were as the independent variables. Multiple linear regression was used to analyze these factors.Results: H-Y stage significantly affected UPDRS II score, UPDRS III score, and getting up time (P<0.01). Madopar dosage and H-Y stage significantly affected the 10 m×2 times (P<0.05 or <0.01). Madopar dosage significantly affected the sleep scale score (P<0.05). There were also significant correlations between age and TMT-left or TMT-right (P<0.01), and duration of PD and TMT-right (P<0.05).Conclusions: The six assessed means of clinical evaluation (including UPDRS II and UPDRS III scores, sleep scale score, getting up time, 10 m×2 times, and turning time) are sensitive indexes in all PD patients. H-Y stage and Madopar dosage are the major factors influencing means of clinical assessment of PD treatment. © 2014, Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg.

Siu W.S.,Institute of Chinese Medicine | Siu W.S.,Chinese University of Hong Kong | Ko C.H.,Institute of Chinese Medicine | Ko C.H.,Chinese University of Hong Kong | And 8 more authors.
Molecular Medicine Reports | Year: 2013

Pharmaceutical countermeasures to treat disuse osteoporosis are rarely studied. Pharmaceutical studies for the treatment and prevention of osteoporosis depend on the ovariectomized rat model, which is a suitable model for the disease in women. Disuse osteoporosis affects men and women, but there is lack of awareness and relevant pharmaceutical studies for this condition. The objectives of this study were to verify the validity of an unusual tail-suspension rat model in the induction of disuse osteoporosis and subsequent pharmaceutical treatments. This model was created by unloading the hind limbs of the rats in order to create a state of weightlessness in their hindlimb bones. Validation of the model was performed with non-suspended rats. This study included five groups of suspended rats fed with different agents, such as distilled water (control), high-, medium- and low-dose raloxifene and a bisphosphonate (alendronate). The experiment lasted for 28 days. Comparisons were made between the suspended control and treatment groups. Ovariectomized and sham-operated rats were also included as a reference for bone changes during osteoporosis. Changes in bone mineral density (BMD) at the distal femur and proximal tibia, microarchitecture at the distal femur and biomechanical strength at the diaphyseal femur were studied. Reduction of BMD and deterioration of trabeculae were similar between the suspended control and ovariectomized rats. Loss of BMD induced by tail suspension was reduced most effectively by medium-dose raloxifene. Deterioration of trabecular microarchitecture was also prevented by raloxifene. The tail-suspension rat model is suitable for the study of disuse osteoporosis under the effects of various therapeutic agents. The preventive effects of raloxifene against bone loss under disuse conditions have been demonstrated using this model.

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