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Morel S.,SONAS EA 921 | Landreau A.,SONAS EA 921 | Landreau A.,Institute of Chemistry VAST | Nguyen V.H.,Institute of Chemistry VAST | And 6 more authors.
Phytochemical Analysis | Year: 2012

Introduction The Derris genus is known to contain flavonoid derivatives, including prenylated flavanones and isoflavonoids such as rotenoids, which are generally associated with significant biological activity. Objective To develop an efficient preparative isolation procedure for bioactive cajaflavanone. Methodology Fast centrifugal partition chromatography (FCPC) was optimised to purify cajaflavanone from Derris ferruginea stems in a single step as compared to fractionation from the cyclohexane extract by successive conventional solid-liquid chromatography procedures. The purification yield, purity, time and solvent consumption per procedure are described. The anti-fungal, anti-bacterial, anti-leishmanial, anti-plasmodial, anti-oxidant activities and the inhibition of advanced glycation end-products (AGEs) by cajaflavanone accumulation are described. Results FCPC enabled cajaflavanone purification in a single separation step, yielding sufficient quantities to perform in vitro biological screening. Interestingly, cajaflavanone had an inhibitory effect on the formation of AGEs, without displaying any in vitro anti-oxidant activity. Conclusion A simple and efficient procedure, in comparison with other preparative methods, for bioactive cajaflavone purification has been developed using FCPC. Copyright © 2011 John Wiley & Sons, Ltd. Source

An N.T.,Institute of Chemistry VAST | Thien D.T.,Institute of Chemistry VAST | Dong N.T.,Institute of Chemistry VAST | Le Dung P.,Institute of Chemistry VAST | And 3 more authors.
Carbohydrate Polymers | Year: 2011

Water-soluble O-methyl glucomannan derivatives (O-MGs) with various degrees of substitution were obtained by direct alkylation reaction of an insoluble glucomannan with methyl iodide without any organic solvent including methanol and dimethyl sulfoxide. The structure of O-MGs was characterized by 1H, 13C, 1H 13C NMR-HSQC, and 1H 13C NMR-HMBC spectra. The reactive conditions for synthesizing of O-MG derivatives were also evaluated. The results shown that the optimal conditions for methylation of glucomannan were pH 10, temperature of 40 °C for 3 h. The degree of substitution (DS) of O-substitution increased from 0.09 to 0.175 since the ratio (w/v) of glucomannan/methyl iodide changed from 1/3 to 1/15. © 2010 Elsevier Ltd. All rights reserved. Source

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