Institute of Chemical Technology Prague
Prague, Czech Republic

University of Chemistry and Technology is the largest university specializing in chemistry in the Czech Republic. It was founded in 1952 and since that time it has been one of the leading research spots in Central Europe. More than 2,000 students are accepted every year. Academic staff comprises 780 teachers including 84 professors, 119 associate professors and 265 assistant professors and 28 assistants.The university consists of four faculties: Faculty of Chemical Technology Faculty of Environmental Technology Faculty of Food and Biochemical Technology Faculty of Chemical Engineering ↑ 1.0 1.1 1.2 Wikipedia.

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Cejkova J.,Institute of Chemical Technology Prague | Stepanek F.,Institute of Chemical Technology Prague
Current Pharmaceutical Design | Year: 2013

Recent advances in the fabrication, characterization and application of micro- and nano-particles that possess a non-uniform internal structure are reviewed. The particle structures include core-shell particles, particles with multiple cores or a multi-layered structure, porous particles with both regular and random pore structure, as well as complex composite particles possessing several of the above features. Particles based on "hard" inorganic materials such as silica, "soft" organic materials such as polymers and their composites are considered. The fabrication approaches include bottom-up self-assembly techniques, templating methods, microfluidics, and various emulsion-based routes to structured micro- and nano-particle formation, combined with both physical (e.g. Pickering emulsions) and chemical (e.g. polymerization, precipitation) processes for the material deposition. The applications of the structured particles for the encapsulation and controlled delivery of active substances are then reviewed with emphasis on those systems where the complex particle structure can provide specific benefits such as in-situ formation of the active substance or precise control over the release profile. Likely future research directions and prospects are discussed. © 2013 Bentham Science Publishers.

Pumera M.,Nanyang Technological University | Sofer Z.,Institute of Chemical Technology Prague
Chemical Society Reviews | Year: 2017

Stoichiometric derivatives of graphene, having well-defined chemical structure and well-defined chemical bonds, are of a great interest to the 2D materials research. Hydrogenated graphene (graphene), fluorographene, hydroxygraphene (graphol), thiographene, cyanographene, aminographene, graphene acid pose unique and well defined chemical and physical properties, allowing their further transformation and application in the devices. Here we overview various methods of their synthesis and discuss their chemistry and properties. It is expected that the family of stochiometric derivatives of graphene will grow beyond listed examples in the near future. © 2017 The Royal Society of Chemistry.

Institute of Chemical Technology Prague and Institute Of Molecular Genetics Of Ascr | Date: 2015-10-07

Pentamethinium salts with an expanded quinoxaline unit and its use in anticancer therapy A pentamethinium salt with an incorpoarted expanded quinoxaline unit which can be used as an agent with a cytostatic effect towards cancer lines and for the suppression of cancer growth.

Agency: GTR | Branch: EPSRC | Program: | Phase: Research Grant | Award Amount: 288.09K | Year: 2014

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Malijevsky A.,Institute of Chemical Technology Prague | Parry A.O.,Imperial College London
Physical Review Letters | Year: 2013

We present results of a microscopic density functional theory study of wedge filling transitions, at a right-angle wedge, in the presence of dispersionlike wall-fluid forces. Far from the corner the walls of the wedge show a first-order wetting transition at a temperature Tw which is progressively closer to the bulk critical temperature Tc as the strength of the wall forces is reduced. In addition, the meniscus formed near the corner undergoes a filling transition at a temperature Tf< Tw, the value of which is found to be in excellent agreement with macroscopic predictions. We show that the filling transition is first order if it occurs far from the critical point but is continuous if Tf is close to Tc even though the walls still show first-order wetting behavior. For this continuous transition the distance of the meniscus from the apex grows as ℓw≈(Tf-T) -βw with the critical exponent βw≈ 0.46±0.05 in good agreement with the phenomenological effective Hamiltonian prediction. Our results suggest that critical filling transitions, with accompanying large scale universal interfacial fluctuation effects, are more generic than thought previously, and are experimentally accessible. © 2013 American Physical Society.

Patakova P.,Institute of Chemical Technology Prague
Journal of Industrial Microbiology and Biotechnology | Year: 2013

The genus Monascus, comprising nine species, can reproduce either vegetatively with filaments and conidia or sexually by the formation of ascospores. The most well-known species of genus Monascus, namely, M. purpureus, M. ruber and M. pilosus, are often used for rice fermentation to produce red yeast rice, a special product used either for food coloring or as a food supplement with positive effects on human health. The colored appearance (red, orange or yellow) of Monascus-fermented substrates is produced by a mixture of oligoketide pigments that are synthesized by a combination of polyketide and fatty acid synthases. The major pigments consist of pairs of yellow (ankaflavin and monascin), orange (rubropunctatin and monascorubrin) and red (rubropunctamine and monascorubramine) compounds; however, more than 20 other colored products have recently been isolated from fermented rice or culture media. In addition to pigments, a group of monacolin substances and the mycotoxin citrinin can be produced by Monascus. Various non-specific biological activities (antimicrobial, antitumor, immunomodulative and others) of these pigmented compounds are, at least partly, ascribed to their reaction with amino group-containing compounds, i.e. amino acids, proteins or nucleic acids. Monacolins, in the form of β-hydroxy acids, inhibit hydroxymethylglutaryl- coenzyme A reductase, a key enzyme in cholesterol biosynthesis in animals and humans. © 2012 Society for Industrial Microbiology and Biotechnology.

Dolensky B.,Institute of Chemical Technology Prague | Havlik M.,Institute of Chemical Technology Prague | Kral V.,Institute of Chemical Technology Prague
Chemical Society Reviews | Year: 2012

Oligo Tröger's bases are compounds containing two or more Tröger's base subunits (1,5-methanodiareno[b,f][1,5]diazocines) sharing one or more arene parts. Due to their interesting molecular shapes, these compounds are studied as chiral molecular tweezers, clips, cavitands, clefts, calixes, etc. This review includes all available data on oligo Tröger's bases, and introduces their preparation and properties to a wide audience. © 2012 The Royal Society of Chemistry.

Cibulka R.,Institute of Chemical Technology Prague
European Journal of Organic Chemistry | Year: 2015

Flavinium salts, both isoalloxazinium and alloxazinium derivatives, are useful organocatalysts of redox reactions, and particularly in recent years, the number of transformations catalysed by flavinium salts has increased. This review outlines the synthetic applications of flavinium catalysts in oxygenation reactions with oxygen and hydrogen peroxide as terminal oxidising agents; these oxidations involve flavin hy- droperoxide as an intermediate, thus mimicking flavin monooxygenases. Special attention is paid to mechanistic studies and to the design of catalytic systems, especially the effects of the structures of flavinium catalysts, and reaction conditions on the efficiency, chemoselectivity and stereoselectivity of oxygenations. © 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Vanura P.,Institute of Chemical Technology Prague
Journal of Radioanalytical and Nuclear Chemistry | Year: 2010

From extraction experiments and y-activity measurements, the exchange extraction constants corresponding to the general equilibrium M2+(aq) + Sr2+(nb) ⇄ M2+(nb) + Sr2+(aq) taking part in the two-phase water-nitrobenzene system (M2+ = Mg 2+,Ca2+,Ba2+,Cu2+, Zn 2+,Cd2+,Pb2+,UO2+,Mn 2+,Fe2+,Co2+,Ni2+; aq = aqueous phase, nb = nitrobenzene phase) were evaluated. Furthermore, the individual extraction constants of the M2+ cations in the mentioned two-phase system were calculated; they were found to increase in the following cation order: UO2+ 2 < Zn2+,Ni2+ < Cu2+,Cd2+ < Co2+ < Mg2+ < Ca2+ < Mn2+,Fe2+ < Sr2+ < Pb2+ < Ba2+. © Akadémiai Kiadó, Budapest, Hungary 2010.

Poh H.L.,Nanyang Technological University | Simek P.,Institute of Chemical Technology Prague | Sofer Z.,Institute of Chemical Technology Prague | Pumera M.,Nanyang Technological University
ACS Nano | Year: 2013

Doping of graphene with heteroatoms is an effective way to tailor its properties. Here we describe a simple and scalable method of doping graphene lattice with sulfur atoms during the thermal exfoliation process of graphite oxides. The graphite oxides were first prepared by Staudenmaier, Hofmann, and Hummers methods followed by treatments in hydrogen sulfide, sulfur dioxide, or carbon disulfide. The doped materials were characterized by scanning electron microscopy, high-resolution X-ray photoelectron spectroscopy, combustible elemental analysis, and Raman spectroscopy. The ζ-potential and conductivity of sulfur-doped graphenes were also investigated in this paper. It was found that the level of doping is more dramatically influenced by the type of graphite oxide used rather than the type of sulfur-containing gas used during exfoliation. Resulting sulfur-doped graphenes act as metal-free electrocatalysts for an oxygen reduction reaction. © 2013 American Chemical Society.

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