Mumbai, India

Institute of Chemical Technology , formerly the University Department of Chemical Technology , is a premier chemical engineering research institute located in Mumbai, Maharashtra, India. It is focused on training and research in various branches of chemical engineering, chemical technology, and pharmacy. It was established in 1933 and was granted deemed university status in 2008. It is the only state-funded deemed university in India. Wikipedia.


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Patent
Institute of Chemical Technology | Date: 2015-01-16

The present invention provides a process for enzyme mediated hydrolysis of biomass for production of soluble sugars, wherein the said process comprises of steady addition of small portions of biomass to enzyme solution, enabling rapid solubilization of biomass. The process used for enzymatic saccharification allows for increased biomass loading, enzyme recycle and mitigation of substrate and product inhibitory effect. The recycling of unhydrolysed biomass along with soluble enzyme ensures complete reuse of the said enzyme for effective repeated hydrolysis thereby increasing the overall productivity of enzyme used.


Kapdi A.R.,Institute of Chemical Technology | Fairlamb I.J.S.,University of York
Chemical Society Reviews | Year: 2014

Much success has been achieved with platinum-based chemotherapeutic agents, i.e. through interactions with DNA. The long-term application of Pt complexes is thwarted by issues, leading scientists to examine other metals such as palladium which could exhibit complementary modes of action (given emphasis wherever known). Over the last 10 years several research groups have focused on the application of an eclectic array of palladium complexes (of the type PdX2L2, palladacycles and related structures) as potential anti-cancer agents. This review therefore provides readers with an up to date account of the advances that have taken place over the past several decades. © 2014 The Royal Society of Chemistry.


Gadge S.T.,Institute of Chemical Technology | Bhanage B.M.,Institute of Chemical Technology
RSC Advances | Year: 2014

Recently, carbonylation reactions have gained considerable interest as they are becoming a versatile tool in the synthesis of pharmaceuticals, agrochemicals and their intermediates. Nowadays, a plethora of transition metal catalysts are available for the synthesis of various functional groups like ureas, carbamates, oxamates, oxamides, α-keto amides, ketones, esters, etc. using carbonylation methodology. Several carbonylation reactions such as aminocarbonylation, alkoxycarbonylation, double carbonylation and oxidative carbonylation, provide efficient and attractive alternatives to the conventional synthetic routes on a laboratory or industrial scale. Oxidative carbonylation is an important reaction as it allows direct carbonylative C-H bond activation. A double carbonylation reaction provides a one step alternative route for the synthesis of α-keto amides, oxamides, and oxamates. It also eliminates the use of conventional thermally unstable and toxic reagents like oxalyl chloride. Several recent studies have focused on the various aspects of these reactions, including catalyst-product separation, and catalyst recoverability and reusability. In view of this, developments in anchoring homogeneous catalysts using various techniques like biphasic catalysis and supported liquid phase catalysis are gaining importance. Carbonylation routes using these techniques are simple, efficient, economical, avoid the use of ligands, and give the desired products in excellent yields. The use of phosphine ligands is disadvantageous as it leads to air/moisture sensitivity, tedious work-up procedures and high work-up costs. Several phosphine-free carbonylation routes eliminate the use of phosphine ligands, and provide economical and simple methods for these transformations. In this review we have summarized the recent trends in carbonylative transformations, which have undergone a rapid development. © 2014 The Royal Society of Chemistry.


Transition-metal catalysed C-H bond functionalisation of arenes and heteroarenes has undergone a tremendous amount of development in the last decade with several reported protocols exhibiting excellent regioselectivity. In this review we intend to emphasise the organometallic aspect of C-H bond functionalisation involving the formation of a metal-carbon bond. © 2014 The Royal Society of Chemistry.


D'Souza A.A.,Institute of Chemical Technology | Devarajan P.V.,Institute of Chemical Technology
Journal of Controlled Release | Year: 2015

Hepatocyte resident afflictions continue to affect the human population unabated. The asialoglycoprotein receptor (ASGPR) is primarily expressed on hepatocytes and minimally on extra-hepatic cells. This makes it specifically attractive for receptor-mediated drug delivery with minimum concerns of toxicity. ASGPR facilitates internalization by clathrin-mediated endocytosis and exhibits high affinity for carbohydrates specifically galactose, N-acetylgalactosamine and glucose. Isomeric forms of sugar, galactose density and branching, spatial geometry and galactose linkages are key factors influencing ligand-receptor binding. Popular ligands for ASGPR mediated targeting are carbohydrate polymers, arabinogalactan and pullulan. Other ligands include galactose-bearing glycoproteins, glycopeptides and galactose modified polymers and lipids. Drug-ligand conjugates provide a viable strategy; nevertheless ligand-anchored nanocarriers provide an attractive option for ASGPR targeted delivery and are widely explored. The present review details various ligands and nanocarriers exploited for ASGPR mediated delivery of drugs to hepatocytes. Nanocarrier properties affecting ASGPR mediated uptake are discussed at length. The review also highlights the clinical relevance of ASGPR mediated targeting and applications in diagnostics. ASGPR mediated hepatocyte targeting provides great promise for improved therapy of hepatic afflictions. © 2015 Elsevier B.V. All rights reserved.


Niakolas D.K.,Institute of Chemical Technology
Applied Catalysis A: General | Year: 2014

The present review is mainly dealing with the latest progress on sulfur poisoning of Solid Oxide Fuel Cell anodes, which in particular operate under reforming conditions. In general, sulfur seems to poison the electrochemical interface and at the same time or even faster blocks the catalytically active sites that are responsible for the H/C conversion, leading finally to the cells' degradation. Worldwide research effort has focused on the development of efficient and tolerant anode materials against carbon deposition and/or sulfur poisoning and one viable approach has been through targeted modifications of the traditional Ni-based anode cermets. In this respect, the review comprises a brief description of anode materials that are less prone to carbon deposition, but the main interest is focused on the studied sulfur tolerant cermets. The latter have been classified into four groups, depending on whether the examined anode feed comprises H2S in H2or H/Cs plus H2S fuels, while there is also discrimination between Ni-free and Nibased anode materials. Finally, the main part of the discussion focuses on the published studies regarding the effect of sulfur on the reforming activity and consequently on the electrochemical performance of H/C fueled Ni-based SOFCs. © 2014 Elsevier B.V. All rights reserved.


Torne S.,Institute of Chemical Technology
Pharmaceutical development and technology | Year: 2013

The purpose of the present study was to develop Tamoxifen loaded β-cyclodextrin nanosponges for oral drug delivery. The three types of Tamoxifen loaded β-cyclodextrin nanosponges were synthesized by varying the molar ratios of β-cyclodextrin to carbonyldiimidazole as a crosslinker viz. 1:2, 1:4 and 1:8. The Tamoxifen nanosponge complex (TNC) with particle size of 400-600 nm was obtained by freeze drying method. Differential scanning calorimetry, Fourier transformed infra-red spectroscopy and X-ray powder diffraction studies confirmed the complexation of Tamoxifen with cyclodextrin nanosponge. AUC and Cmax of TNC formulation (1236.4 ± 16.12 μg · mL(-1) h, 421.156 ± 0.91 μg/mL) after gastric intubation were 1.44 fold and 1.38 fold higher than plain drug (856.079 ± 15.18 μg · mL(-1) h, 298.532 ± 1.15 μg/mL). Cytotoxic studies on MCF-7 cells showed that TNC formulation was more cytotoxic than plain Tamoxifen after 24 and 48 h of incubation.


Patent
Institute of Chemical Technology | Date: 2012-11-20

A process for production of fermentable sugars from biomass using multi-enzyme multi-step system is provided herein. The process disclosed in the present invention provides high yielded sugars in less time period. The multi-enzyme system disclosed in the present invention converts celluloses, hemicelluloses and/or mixture thereof to fermentable sugar with higher efficiency and better economics than the process known in the prior art. Cellulose and hemicelluloses fractions derived from natural sources such as any lignocellulosic biomass are saccharified in a shortened time with higher conversion rates of intermediates with modified enzymatic compositions/groups of the Multi-enzyme system to enhance the rate thus providing an economical cellulose and hemicellulose saccharification process.


Patent
Institute of Chemical Technology | Date: 2012-11-20

A process for production of fermentable sugars from biomass using multi-enzyme multi-step system is provided herein. The process disclosed in the present invention provides high yielded sugars in less time period. The multi-enzyme system disclosed in the present invention converts celluloses, hemicelluloses and/or mixture thereof to fermentable sugar with higher efficiency and better economics than the process known in the prior art. Cellulose and hemicelluloses fractions derived from natural sources such as any lignocellulosic biomass are saccharified in a shortened time with higher conversion rates of intermediates with modified enzymatic compositions/groups of the Multi-enzyme system to enhance the rate thus providing an economical cellulose and hemicellulose saccharification process.


Patent
Institute of Chemical Technology | Date: 2013-01-30

An efficient process for enzymatic hydrolysis of fats and oils in a homogenous mixture is provided herein. The present invention in particular provides a process for production of fatty acids, sn-regio mono-acylglycerol (MAG), sn-regio di-acyl-glycerols (DAG), and glycerol from fats, wherein more than 98% fats can be converted into the desired product. The present invention also provides a process for the production of fatty acids and glycerol, virtually free of sn-regio diacyl-glycerols (DAG) and comprising less than 5% sn-regio mono-acylglycerol (MAG) in the end product.

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