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Kemelbekov U.,Institute of Chemical science of MES RK | Luo Y.,Free University of Berlin | Orynbekova Z.,Institute of Chemical science of MES RK | Rustembekov Z.,Institute of Chemical science of MES RK | And 3 more authors.
Journal of Inclusion Phenomena and Macrocyclic Chemistry | Year: 2011

The interaction of the analgesic prosidol [1-(2-ethoxyethyl)-4-phenyl-4- propionyl-oxypiperidine] and the anaesthetic kazcaine [1-(2-ethoxyethyl)-4- ethynyl-4-benzoyloxypiperidine] with β-cyclodextrin (β-CD) in aqueous solutions has been studied by nuclear magnetic resonance (NMR), ultraviolet (UV) and infrared (IR) spectroscopy. The composition and structure of the formed guest:β-CD inclusion complexes have been determined and were found to have a molar ratio of 1:2, with the guest molecule located in the cavity formed by two β-CD molecules in head-to-head orientation, with the O(2), O(3) rims interacting. The phenyl and ethoxyethyl substituents of the guests are in contact with the β-CD molecules. In contrast to prosidol-base and kazcaine-base the complexes with β-CD show a higher analgesic and local anaesthetic activity. © 2010 Springer Science+Business Media B.V.

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