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Furnica C.,Grigore T. Popa University of Medicine and Pharmacy | Constantin M.-M.L.,Grigore T. Popa University of Medicine and Pharmacy | Chistol R.O.,Grigore T. Popa University of Medicine and Pharmacy | Chistol R.O.,Institute of Cardiovascular Diseases of Iasi | And 4 more authors.
Revista de Chimie | Year: 2015

Atypical antipsychotic drugs are the first-line of therapy in adult schizophrenia but their effects in children and adolescents have not been well understood. In the current paper there is presented a case of early-onset schizophrenia (EOS) with complex prodromal symptoms for 6 months prior to the acute psychotic episode, followed by an aggravation of the condition with a suicidal attempt secondary to inadequate medication with a dopamine antagonist and a dopamine partial agonist. The patient finally responded to aripiprazole monotherapy with lack of psychiatric symptoms and improvement of social integration for over a year. In our opinion, a multidisciplinary approach involving the research of biochemical interactions between antipsychotic drugs may allow a better understanding of mental diseases, which in turn will contribute to the establishment of the most appropriate diagnostic and therapeutic scheme.

Anghel D.,Grt Popa University Of Medicine And Pharmacy Of Iasi | Anghel D.,Institute of Cardiovascular Diseases of Iasi | Anghel R.,Grt Popa University Of Medicine And Pharmacy Of Iasi | Corciova F.,Institute of Cardiovascular Diseases of Iasi | And 4 more authors.
BioMed Research International | Year: 2014

Atrial fibrillation is still the most common arrhythmia that occurs in heart surgery. However, there is few literature data on the manner in which preoperative atrial fibrillation may influence the postoperative outcome of various heart surgery procedures. The purpose of our research is to assess the effects of preoperative atrial fibrillation on patients having undergone different heart surgery procedures. The results of our research are a review of clinical data which were collected prospectively, over a 10-year period, from all the patients who had undergone heart surgery in our Institute. The study group included 1119 heart surgery patients, who were divided as follows: the preoperative AFib group (n = 226, 20.19%) and the sinus rhythm group (n = 893, 79.80%). Major postoperative complications and hospital mortality rates were analyzed. According to our statistical analysis, preoperative atrial fibrillation significantly increased the mortality risk (P = 0.001), the patients' mechanical ventilation needs (P = 0.022), the rate of occurrence of infectious complications (P < 0.5), the rate of occurrence of complications such as acute kidney failure (P = 0.012), and the time spent by the patients in the intensive care ward (P < 0.01). In conclusion, preoperative atrial fibrillation in heart surgery patients increases the mortality and major complication risk further to heart surgery. © 2014 Diana Anghel et al.

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