Institute of Cancer Stem Cell

Institute of Cancer Stem Cell

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Yang C.,Dalian Medical University | Liu L.,Institute of Cancer Stem Cell | Lan X.,Dalian Medical University | Zhang S.,Dalian Medical University | And 2 more authors.
Medicine (United States) | Year: 2017

Rationale: Melanoma metastases to the pituitary adenoma (MMPA) are extremely rare, with only 1 reported case. To date, the melanoma metastasis to the existing prolactinoma has not been reported in literatures. Patient concerns: We report a case of 62-year-old woman presented with progressive visual disturbance and hyperprolactinemia. Magnetic resonance imaging demonstrated the presence of a round sellar mass. Diagnoses: Melanoma metastasis to the pituitary adenoma. Interventions: Surgery was performed and intraoperative frozensection examination found melanin granules and histopathological examination confirmed melanoma metastasis to the pituitary adenoma. Outcomes: After surgery, the patient developed widespread melanoma metastasis to lower limbs. Twenty-two months later, the patient was alive with worse symptoms. Lessons: We reviewed and analyzed the clinical data, imaging features, and treatment methods of other reported cases of metastases to pituitary adenoma (MPA). Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc.


Qian X.-K.,Institute of Cancer Stem Cell | Wang P.,CAS Dalian Institute of Chemical Physics | Xia Y.-L.,CAS Dalian Institute of Chemical Physics | Dou T.-Y.,CAS Dalian Institute of Chemical Physics | And 6 more authors.
Sensors and Actuators, B: Chemical | Year: 2016

Catechol-O-methyltransferase (COMT), one of the most important phase II drug metabolizing enzymes, plays important roles in the metabolism of endogenous and xenobiotic catechols. In this study, a highly selective fluorescent probe for sensing activities of catechol-O-methyltransferase in complex biological samples was discovered and well characterized. Under physiological conditions, COMT selectively catalyzes the conversion of the probe (7,8-dihydroxy-4-methylcoumarin, DHMC) to 7-hydroxy-8-methoxy-4-methylcoumarin (HMMC), which brings a strong turn-on fluorescence signal at 520 nm. The probe substrate has been used for monitoring the real activities of COMT in complex biological samples, as well as for rapid screening of potential COMT inhibitors which are useful in the treatment of Parkinson's diseases Furthermore, the probe has been successfully used to monitor endogenous COMT in living cells for the first time, and the results demonstrate that DHMC is cell membrane permeable and low toxic to the cells. All these features of DHMC suggested that this probe holds great promise for COMT-related regulation and inhibition assays in drug discovery, as well as for further investigation on the biological functions of COMT in living cells. © 2016 Elsevier B.V.

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