Kumar M.,Swami Devi Dyal Institute of Pharmacy |
Munshi S.K.,Pcte Institute Of Biotechnology |
Singla R.,Swami Devi Dyal Institute of Pharmacy |
Kumar D.,Swami Devi Dyal Institute of Pharmacy
Pharma Research | Year: 2011
The medicinal plants play very important role in different health care systems. Traditional system of medicine recommended various hepatoprotective agents and preparations to treat hepatic disorders. Polyherbal formulation F1 was developed and evaluated for its hepatoprotective effects using acute liver toxicity with paracetamol intoxication in mice. The formulation F1 is composed with Andrographis paniculata (Kalmegh), Boerhavia diffusa (Punarnava), Eclipta alba (Bhringraj) and Picrorhiza kurroa (Kutki). The hepatoprotective assessment was done with serum biochemical parameters as serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, alkaline phosphatase, bilirubin, triglyceride and lipid peroxidation. F1 showed significant hepatoprotective activity at dose of 400 mg/kg, which was comparable to standard drug: silymarin at 50 mg/kg. F1 markedly reversed the toxic effects of paracetamol as reflected by the modulation in these biochemical estimations. The result of the study strongly indicates that formulation F1 has a potent hepatoprotective action against paracetamol induced hepatic damage in mice. © 2009 by Sudarshan Publication Sudarshan Institute of Technical Education Pvt. Ltd.