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Yang Y.-C.,Mackay Memorial Hospital | Yang Y.-C.,Taipei Medical University | Chang T.-Y.,Mackay Memorial Hospital | Chen T.-C.,Mackay Memorial Hospital | And 5 more authors.
Human Immunology | Year: 2013

Cervical cancer is strongly associated with infection of oncogenic types of human papillomavirus (HPV). However, HPV infection alone is not sufficient for progression to cervical cancer. It is now recognized that host immunogenetic background participates in the control of HPV infection and development of cervical cancer. Interleukin-18 (IL-18) is a multifunctional cytokine that induces interferon-gamma secretion and plays a central role in antitumor immunity. The aim of this study is to determine if potentially functional polymorphisms in IL-18 gene are associated with risk of HPV-induced cervical cancer in Taiwanese women. Pre-Developed TaqMan Allelic Discrimination Assay was used to genotype IL-18 - 1297 T/C, - 607 C/A, - 380 C/G, - 137 G/C, and + 105 A/C polymorphisms in a hospital-based study of 470 women with cervical squamous cell carcinoma (CSCC) and 722 age-matched healthy control women. The presence and genotypes of HPV in CSCC was determined by PCR. None of the polymorphisms or any haplotype was found to have significant differences in distribution among all subjects with CSCC, those with HPV-16 positive CSCC, and controls. Our results suggest that the IL-18 - 1297 T/C, - 607 C/A, - 380 C/G, - 137 G/C, and + 105 A/C polymorphisms are not associated with susceptibility to CSCC in Taiwanese women. © 2013 American Society for Histocompatibility and Immunogenetics.


Yang Y.-C.,Mackay Memorial Hospital | Yang Y.-C.,Taipei Medical University | Chang T.-Y.,Mackay Memorial Hospital | Chen T.-C.,Mackay Memorial Hospital | And 5 more authors.
European Journal of Cancer | Year: 2014

Background The mere presence of human papillomavirus (HPV) is not enough for cervical cancer development and immunogenetic background may play an important role. Human leucocyte antigen (HLA)-G acts as a negative regulator of immune responses and its expression in tumour cells may enable them to avoid immune attack. We aim to study if polymorphisms in the HLA-G gene are associated with cervical cancer risk in Taiwanese women. Methods +1537 A/C, 14-bp deletion/insertion (Del/Ins), and +3142 G/C polymorphisms were genotyped in a hospital-based study of 317 women with cervical squamous cell carcinoma (CSCC) and 400 healthy control women frequency matched by age. The presence and genotypes of HPV in CSCC were determined. Results We found the +3142 C/C genotype and C allele were associated with increased risk for CSCC (adjusted odds ratio [OR] = 1.78, P = 0.004; adjusted OR = 1.31, P = 0.014, respectively). In subgroup analysis based on HPV type 16 positivity, significant associations with higher adjusted ORs were found in +3142 C/C genotype and C allele (adjusted OR = 2.19, P = 0.001; adjusted OR = 1.48, P = 0.003, respectively) and +1537 C/C genotype and C allele frequencies increased significantly (adjusted OR = 2.88, P = 0.004; adjusted OR = 1.69, P = 0.0005, respectively). Furthermore, the C-Del-C haplotype conferred increased risk of both CSCC and HPV-16 positive CSCC women (adjusted OR = 1.41, P = 0.009; adjusted OR = 1.94, P = 0.0001, respectively). Conclusion These findings suggest that HLA-G gene is involved in the susceptibility to CSCC. © 2013 Elsevier Ltd. All rights reserved.

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