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Stagni R.,University of Bologna | Bisi M.C.,University of Bologna | Jobbaggy A.,Budapest University of Technology and Economics | Bliznakov Z.,Institute of Biomedical Technology
IFMBE Proceedings | Year: 2011

Quality assurance and accreditation is an essential aspect for the harmonization of BME curricula in Europe. The definition of common criteria per curricula definition and credit transfer might not be effective is the actual implementation and outcome by means of an effective Quality Assessment system. The purpose of the present contribution is to present a review of existing Quality Assessment systems existing in European and partner countries for BME programs, aiming to identify a possible common basis for the definition of a template guidance document and eventual constraints resulting from local legislation that might prevent harmonization. © 2011 Springer-Verlag Berlin Heidelberg. Source


Staff S.,Laboratory of Cancer Biology | Staff S.,University of Tampere | Tolonen T.,Fimlab Laboratories | Laasanen S.-L.,University of Tampere | And 4 more authors.
International Journal of Gynecological Pathology | Year: 2014

Mutations in BRCA1 and BRCA2 genes confer an increased lifetime risk for breast and ovarian cancer. Increased lifetime ovarian cancer risk among BRCA1/BRCA2 mutation carriers can be substantially decreased by risk-reducing salpingo-oophorectomy (RRSO), which also provides material for molecular research on early pathogenesis of serous ovarian cancer. RRSO studies have suggested fallopian tube as a primary site of serous high-grade ovarian cancer. In this study, the nuclear expression levels of γ-H2AX and p53 using immunohistochemical (IHC) study was quantitatively assessed in ovarian and fallopian tube epithelium derived from RRSOs in 29 BRCA1 and BRCA2 mutation carriers and in 1 patient with a strong family history of breast and ovarian cancer but showing an unknown BRCA status. Both p53 and γ-H2AX nuclear staining levels were significantly higher in BRCA1/2 mutation-positive fallopian tube epithelium compared with the control fallopian tube epithelium (P<0.006 and P=0.011, respectively). Nuclear expression levels of p53 and γ-H2AX were similar between the BRCA1/2 mutation-positive ovarian epithelium and controls. Both γ-H2AX and p53 showed significantly higher nuclear expression levels in BRCA1/2 mutation-positive fallopian tube epithelium compared with BRCA1/2 mutation-positive ovarian epithelium (P<0.0001 and P<0.0001, respectively). BRCA1/2 mutation-positive fallopian tube epithelium showed a positive correlation between the γ-H2AX and p53 nuclear expression levels (Pearson r=0.508, P=0.003). Our results of quantitative nuclear p53 and γ-H2AX expression levels in ovarian and fallopian tube epithelium derived from RRSO in high-risk patients support the previously suggested role of fallopian tube epithelium serving as a possible site of initial serous ovarian carcinogenesis. © 2014 International Society of Gynecological Pathologists. Source


Celli J.,Leiden University | Dalgleish R.,University of Leicester | Vihinen M.,Institute of Biomedical Technology | Taschner P.E.,Leiden University | den Dunnen J.T.,Leiden University
Human Mutation | Year: 2012

Gene variant databases or Locus-Specific DataBases (LSDBs) are used to collect and display information on sequence variants on a gene-by-gene basis. Their most frequent use is in relation to DNA-based diagnostics, giving clinicians and scientists easy access to an up-to-date overview of all gene variants identified worldwide and whether they influence the function of the gene (" pathogenic or not"). While literature on gene variant databases is extensive, little has been published on the process of database curation itself. Based on our extensive experience as LSDB curators and our contributions to database curation courses, we discuss the subject of database curation. We describe the tasks involved, the steps to take, and the issues that might occur. Our overview is a first step toward establishing overall guidelines for database curation and ultimately covers one aspect of establishing quality-assured gene variant databases. © 2011 Wiley Periodicals, Inc. Source


Tsekouras K.,University of Patras | Papathanassopoulos F.,Institute of Biomedical Technology | Kounetas K.,University of Patras | Pappous G.,University of Patras
International Journal of Production Economics | Year: 2010

In the last decade, a significant amount of financial resources has been devoted by the Greek Government and the European Union to provide the intensive care units (ICU) of the Greek Public Health Care System with high-tech medical equipment in order to improve their productive efficiency. Using a unique data set, we employ the DEA bootstrap of Simar and Wilson (2007) approach to estimate the efficiency of each ICU and to explore the impact of these investments on their efficiency. Our results indicate that, although the technical efficiency is benefited from the embodiment of new medical technology, the scale efficiency remains unaffected. The role of the asymmetric information, of the ICUs' proximity to pools of knowledge and of the composition of the medical personnel, seems to be the crucial factors for the improvement of their productive efficiency. © 2010 Elsevier B.V.All rights reserved. Source


Malataras P.G.,Institute of Biomedical Technology | Bliznakov Z.B.,University of Patras | Pallikarakis N.E.,University of Patras
IFMBE Proceedings | Year: 2015

The use of medical equipment management software tools has been introduced in the field of clinical engineering since the beginning of the 80’s. Nowadays the tremendous expansion of Internet has changed both the way these tools function and the capabilities they provide to the user. This work presents a medical equipment management software system which has been developed to operate as a web service. In addition, its main characteristics are presented in comparison with the previous client-server and standalone versions. Finally, the benefits of such an implementation are discussed. © Springer International Publishing Switzerland 2015. Source

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